Engineering Analysis of Non-Braided Polycaprolactone Bioresorbable Flow Diverters for Aneurysms.

This paper reports a nonbraided, bioresorbable polycaprolactone (PCL) flow diverter (FD) for the endovascular treatment of aneurysms. Bioresorbable FDs can reduce the risk associated with the permanent metallic FDs as they are resorbed by the body after curing of aneurysms. PCL FDs were designed and fabricated using an in-house hybrid electromelt spinning-fused deposition fabrication unit.

Proteomics evaluation of five economical commercial abundant protein depletion kits for enrichment of diseases-specific biomarkers from blood serum.

Blood serum is arguably the most analyzed biofluid for disease prediction and diagnosis. Herein, we benchmarked five different serum abundant protein depletion (SAPD) kits with regard to the identification of disease-specific biomarkers in human serum using bottom-up proteomics. As expected, the IgG removal efficiency among the SAPD kits is highly variable, ranging from 70% to 93%.

Experimental Analysis of Laser Micromachining of Microchannels in Common Microfluidic Substrates.

Laser micromachining technique offers a promising alternative method for rapid production of microfluidic devices. However, the effect of process parameters on the channel geometry and quality of channels on common microfluidic substrates has not been fully understood yet. In this research, we studied the effect of laser system parameters on the microchannel characteristics of Polydimethylsiloxane (PDMS), polymethyl methacrylate (PMMA), and microscope glass substrate-three most widely used materials for microchannels.

Effect of Process Parameters and Material Properties on Laser Micromachining of Microchannels.

Laser micromachining has emerged as a promising technique for mass production of microfluidic devices. However, control and optimization of process parameters, and design of substrate materials are still ongoing challenges for the widespread application of laser micromachining. This article reports a systematic study on the effect of laser system parameters and thermo-physical properties of substrate materials on laser micromachining.

Electrodeformation of Vesicles Suspended in a Liquid Medium.

Deformation of flexible vesicles suspended in a fluid medium due to an applied electric field can provide valuable insight into deformation dynamics at a very small scale. In an electric field, the response of the vesicle membrane is strongly influenced by the conductivity of surrounding fluid, vesicle size and shape, and the magnitude of applied field. We studied the electrodeformation of vesicles immersed in a fluid media under a DC electric field.

Modeling and simulation of dielectrophoretic particle-particle interactions and assembly.

Electric field induced particle-particle interactions and assembly are of great interest due to their useful applications in micro devices. The behavior of particles becomes more complex if multiple particles interact with each other at the same time. In this paper, we present a numerical study of two dimensional DC dielectrophoresis based particle-particle interactions and assembly for multiple particles using a hybrid immersed interface-immersed boundary method.

Preconcentration and detection of the phosphorylated forms of cardiac troponin I in a cascade microchip by cationic isotachophoresis.

This paper describes the detection of a cardiac biomarker, cardiac troponin I (cTnI), spiked into depleted human serum using cationic isotachophoresis (ITP) in a 3.9 cm long poly(methyl methacrylate) (PMMA) microfluidic channel. The microfluidic chip incorporates a 100× cross-sectional area reduction, including a 10× depth reduction and a 10× width reduction, to increase sensitivity during ITP.