Publications by authors named "Mohammad Reza Moghaddas"
Article Synopsis
- The study analyzes how different familial structures influence the heritability and prediction accuracy of Type 2 Diabetes (T2D) using data from 11,818 individuals, including genetic information and family pedigrees.
- It identifies three familial structure scenarios to determine their impact on estimating heritability, highlighting that including families with various disease statuses leads to more accurate results.
- The research reveals that while familial structures enhance heritability estimations, omitting certain families can improve disease risk prediction and strengthen correlations with Polygenic Risk Scores.
The Tehran cardiometabolic genetic study (TCGS) is a large population-based cohort study that conducts periodic follow-ups. TCGS has created a comprehensive database comprising 20,367 participants born between 1911 and 2015 selected from four main ongoing studies in a family-based longitudinal framework. The study's primary goal is to identify the potential targets for prevention and intervention for non-communicable diseases that may develop in mid-life and late life.
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