Human Umbilical Cord Mesenchymal Stem Cells Differentiated into Neuron-Like Cells via Laminin and Schwann Cells.

Background: Human umbilical cord mesenchymal stem cells (hUMSCs) have been considered to repair damaged tissues and cells. This study aims to investigate the differentiation efficiency affected by Schwann cells (SCs) and laminin and also compare them to other strategies using chemicals or growth factors.

Methods: SCs and hUMSCs were separated from dorsal root ganglion of rats and newborn human umbilical cords (hUCs), respectively, and then cultured.