Publications by authors named "Mohammad Reza Ebrahimpour"
Article Synopsis
- The study investigates the genetic factors contributing to acute myeloid leukemia (AML) in Iranian patients, focusing on the expression of CEBPA and another unidentified gene.
- There was a significant increase in the expression of both genes in AML patients compared to healthy controls, particularly noting differences based on gender and different FAB subtypes of AML.
- The findings suggest that these genes could play a crucial role in the disease's development, indicating that further research could lead to new treatment options for AML.
Autosomal recessive (AR) gene defects are the leading genetic cause of intellectual disability (ID) in countries with frequent parental consanguinity, which account for about 1/7th of the world population. Yet, compared to autosomal dominant de novo mutations, which are the predominant cause of ID in Western countries, the identification of AR-ID genes has lagged behind. Here, we report on whole exome and whole genome sequencing in 404 consanguineous predominantly Iranian families with two or more affected offspring.
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