Effect of acute and chronic administration of carbamazepine on Cisplatin-induced hyperalgesia in rats.

Background: Cisplatin is an effective antineoplastic drug used extensively in the treatment of malignancies. It induces painful peripheral neuropathy at high doses.

Objectives: The aim of this study was to investigate the effect of carbamazepine (CBZ) on cisplatin-induced peripheral neuropathic pain by using the tail-flick test.