Publications by authors named "Mohammad Rafiul Hoque"
Article Synopsis
- The prevalence of the Poc malaria parasite has significantly increased in sub-Saharan Africa and Southeast Asia, but its invasion mechanism is not well understood.
- This study focused on characterizing the Duffy binding protein of Poc (PocDBP), which plays a crucial role in how the parasite invades reticulocytes (young red blood cells).
- The research demonstrated that the PocDBP-RII protein has a stronger binding ability to reticulocytes compared to erythrocytes and that this binding is affected by specific enzymes and antibodies, indicating its importance in the infection process.
Malaria is caused by multiple different species of protozoan parasites, and interventions in the pre-elimination phase can lead to drastic changes in the proportion of each species causing malaria. In endemic areas, cross-reactivity may play an important role in the protection and blocking transmission. Thus, successful control of one species could lead to an increase in other parasite species.
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- * The study analyzed blood samples from Sudan to investigate variations in the pvdbpII gene and the Duffy blood group, finding 20 single nucleotide polymorphisms (SNPs) and 11 distinct haplotypes among local P. vivax isolates.
- * Results indicated that the pvdbpII gene has undergone positive natural selection, which presents challenges for designing a universal vaccine based on DBP, due to the genetic diversity observed.
Article Synopsis
- Malaria invasion into red blood cells is a fast process governed by specific ligand-receptor interactions, posing challenges for developing effective vaccines targeting Plasmodium knowlesi.
- This study tested pre-clinical vaccine candidates by creating an in vitro invasion inhibition assay with P. knowlesi, focusing on the Duffy binding protein alpha (PkDBPα) and apical membrane antigen 1 (PkAMA1) proteins.
- The research found that antibodies against PkDBPα and PkAMA1 significantly inhibited the growth of the malaria parasite and showed that these proteins are prevalent in human patients, supporting their potential for vaccine development.
Background: Emergence of artemisinin-resistant malaria in Southeast Asian countries threatens the global control of malaria. Although K13 kelch propeller has been assessed for artemisinin resistance molecular marker, most of the mutations need to be validated. In this study, artemisinin resistance was assessed by clinical and molecular analysis, including k13 and recently reported markers, pfarps10, pffd and pfmdr2.
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