Pembrolizumab for the treatment of Progressive Multifocal Leukoencephalopathy (PML) in a patient with AIDS: A case report and literature review.

Progressive multifocal leukoencephalopathy (PML) is an opportunistic central nervous system (CNS) infection caused by the reactivation of John Cunningham polyomavirus (JCV) from suppression of the host immune system due to conditions such as human immunodeficiency virus causing acquired immunodeficiency syndrome (HIV/AIDS), hematological malignancies, multiple sclerosis, and use of immunosuppressant medications. Pembrolizumab is an immune checkpoint inhibitor targeting programmed cell death protein-1 (PD-1) receptors on lymphocytes. In recent years its use is expanding to treat several malignancies and it is a drug of interest for the treatment of PML.

Prevalence of SARS-CoV-2 among community members presenting for testing in Peoria, Illinois from 21 April to 15 May 2020.

Expanding easily accessible community SARS-CoV-2 screening is essential in the response to the COVID-19 pandemic. In this report, we describe the findings from the initial 25 days of a SARS-CoV-2 drive-up and walk-up testing initiative was organized in Peoria, Illinois. Eighty-seven out of 4,073 individuals (2.

Staphylococcus aureus bacteremia: compliance with standard treatment, long-term outcome and predictors of relapse.

The long-term outcome of compliance with standard treatment recommendations for Staphylococcus aureus bacteremia was assessed. Cases of S. aureus bacteremia at our institution over a 2-y period were reviewed and follow-up performed by review of subsequent admissions or contact with primary care physicians.

Pregnancy-associated pyogenic sacroiliitis: case report and review.

Background: Pyogenic sacroiliitis occurs infrequently during the peripartum period.

Case: A case at our institution and a review of the literature were analyzed. A total of 15 cases were discovered.

Uterine granulomas: clinical and pathologic features.

We retrospectively studied the clinical and pathologic features of uterine granulomas over a 10-year period. Granulomas were detected in 30 women, 22 to 81 years old, in the cervix (n = 12/1,090 cervical specimens; 1.1%) or uterine corpus (n = 18/12,000 uterine specimens; 0.

Coccidioidal meningitis: incidental diagnosis 3 y after ventriculo-peritoneal shunt placement for hydrocephalus.

A patient from the American Midwest developed hydrocephalus after a trip to southwest California, necessitating placement of a ventriculo-peritoneal shunt. Coccidioidal meningitis was diagnosed incidentally 3 y later, during evaluation for shunt malfunction.