Recent Focuses in the Syntheses and Applications of Magnetic Metal-Organic Frameworks.

In this article, we examine the recent uses of magnetic metal-organic frameworks (MMOFs). MMOFs can be used in various fields such as water purification, laboratory, food, environment, etc. Their materials can be composed of different metals and ligands, each of which has its own properties.

Greener Syntheses of Coumarin Derivatives Using Magnetic Nanocatalysts: Recent Advances.

Coumarins (2H-1-benzopyran-2-ones) are an important group of biological heterocyclic compounds present in various parts of many plant species, encompassing an array of biological and pharmaceutical activities. In view of the importance of coumarins in heterocyclic chemistry and biological sciences and recent advances in the design of magnetic nanocatalysts, we present herein recent developments pertaining to their synthesis exclusively using magnetic nanoparticles, which can be retrieved easily and thus conform to the tenets of greener synthesis. The preparation of various types of coumarins such as Pechmann-based coumarins, bis coumarins, pyranocoumarins, and coumarin derivatives bearing amine moiety, linked to nicotinonitriles, N-coumarin-2-furanone, and pyrrole-linked chromene derivatives using nanocatalysts with a FeO core are described.

Evaluation of [Tc][Tc-HYNIC/EDDA]-Tyr as a target for metabolic tumor imaging in B16F10 melanoma tumor.

Objectives: Clinical interest in metabolic imaging of cancer has been growing in recent years. The increase in protein metabolism of cancer cells is interesting target for metabolic tumor imaging, for which radiolabeled amino acids can be applied. The aim of this study was to evaluate a newly developed radiolabeled amino acid as an imaging protein metabolism in melanoma tumor.

Green synthesis of novel 5-amino-bispyrazole-4-carbonitriles using a recyclable FeO@SiO@vanillin@thioglycolic acid nano-catalyst.

Bis(thioglycolic acid)-vanillin (2,2'-(((4-hydroxy-3-methoxyphenyl)methylene)bis(sulfanediyl))diacetic acid)-functionalized silica-coated FeO magnetic nanoparticles (FeO@SiO@vanillin@thioglycolic acid MNPs) were synthesized and characterized by transmission electron microscopy (TEM), field emission scanning electron microscopy (FE-SEM), thermogravimetric analysis/differential thermogravimetry (TGA-DTG), X-ray powder diffraction (XRD), X-ray spectroscopy (EDX), vibrating sample magnetometry (VSM), zeta potential measurements and Fourier transform infrared spectroscopy (FT-IR). The ensuing MNPs offer an environmentally friendly procedure for the synthesis of novel 5-amino-pyrazole-4-carbonitriles a three-component mechanochemical reaction of synthesized azo-linked aldehydes or synthesized pyrazolecarbaldehydes, malononitrile, and phenylhydrazine or -tolylhydrazine adhering to the green chemistry principles; products were generated expeditiously in high yields. The catalyst could be quickly recovered and reused for six cycles with almost consistent activity.

Synthesis of Novel Azo-Linked 5-Amino-Pyrazole-4-Carbonitrile Derivatives Using Tannic Acid-Functionalized Silica-Coated FeO Nanoparticles as a Novel, Green, and Magnetically Separable Catalyst.

Tannic acid-linked silica-coated FeO nanoparticles (FeO@SiO@Tannic acid) were prepared and characterized by transmission electron microscope (TEM), field emission scanning electron microscope (FE-SEM), X-ray powder diffraction (XRD), X-ray spectroscopy (EDX), vibrating sample magnetometry (VSM), and Fourier transform infrared (FT-IR) spectroscopy. FeO@SiO@Tannic acid supplies an environmentally friendly procedure for the synthesis of some novel 5-amino-pyrazole-4-carbonitriles through the threecomponent mechanochemical reactions of synthetized azo-linked aldehydes, malononitrile, and phenylhydrazine or -tolylhydrazine. These compounds were produced in high yields and at short reaction times.

Synthesis of Fused Azo-linked Acridine Derivatives Using MCM-41/Ag2S-RHA Nanocomposite.

Introduction: In this study, the synthesis of azo-linked acridine by the reaction of dimedone and synthesized diazoaryl-(2-amino-5-(phenyl)methanone using Ag2S/RHA-MCM-41nanocomposite is reported.

Materials And Methods: The synthesized catalyst was characterized by FT-IR, XRD, and SEM. According to the obtained results, AgS/RHA-MCM-41 nanocomposite exhibited high activity in the synthesis of azo-acridine derivatives based on desirable yields and reaction time.

Tetramethylguanidine-functionalized melamine as a multifunctional organocatalyst for the expeditious synthesis of 1,2,4-triazoloquinazolinones.

Novel nano-ordered 1,1,3,3-tetramethylguanidine-functionalized melamine (Melamine@TMG) organocatalyst was prepared and adequately identified by various techniques including FTIR, EDX, XRD and SEM spectroscopic or microscopic methods as well as TGA and DTG analytical methods. The Melamine@TMG, as an effective multifunctional organocatalyst, was found to promote smoothly the three-component synthesis of 1,2,4-triazoloquinazolinone derivatives using cyclic dimedone, 3-amino-1,2,4-triazole and different benzaldehyde derivatives in EtOH at 40 °C. This practical method afforded the desired products in high to excellent yields (86-99%) and short reaction times (10-25 min).

One-pot Synthesis of a New Category of 2-aryl-quinazolinones Using OImDSA as an Efficient Heterocyclic Medium.

Background: Dihydroquinazolinone derivatives are an important family of fused heterocyclic compounds which possess a wide range of biological, medicinal and pharmacological properties such as anti-tumor, anti-biotic, diuretic, analgesic, anti-hypertonic, anti-pyretic, antidepressant, anti-histamine and vasodilation activities.

Introduction: So far, some acid catalysts, e.g.

NiFeO@SiO n Pr@glucose Catalyzed Synthesis of Novel 5-pyrazolin-1,2,4- triazazolidine-3-ones (thiones).

Introduction: NiFe2O4@SiO2nPr@glucose catalyzed synthesis of novel 5-pyrazolin-1,2,4-triazazolidine- 3-ones (thiones).

Materials And Methods: Amino glucose-functionalized silica-coated NiFeO nanoparticles (NiFeO@SiO nPr@glucose amine or NiFeO@SiP@GA) were synthesized and characterized by X-ray powder diffraction (XRD), X-ray spectroscopy (EDX), transmission electron microscope (TEM), field emission scanning electron microscope (FE-SEM), vibrating sample magnetometry (VSM) and fourier transform infrared spectroscopy (FTIR).

Results And Discussion: NiFeO@SiP@GA supply an eco-friendly procedure for the synthesis of some novel 5- pyrazolin-1,2,4-triazazolidine-3-ones or thiones through one-pot reaction of thiosemicarbazide (hydrazinecarbothioamide) and synthetized pyrazole carbaldehydes.

Preparation and assessment of a new radiotracer technetium-99m-6-hydrazinonicotinic acid-tyrosine as a targeting agent in tumor detecting through single photon emission tomography.

The goal of investigation was to bring up an impressive way to synthesize technetium-99 m-6-hydrazinonicotinic acid-tyrosine (Tc-HYNIC-Tyr), a newfound radiotracer, and to assess the capacity of being as a tumor scintigraphy agent. The conjugate was prepared by solid phase method using tritely chloride resin. The precursor HYNIC-Tyr was labeled with Tc which was accomplished at 100 °C through the coligands tricine and EDDA.

Acidic Ionic Liquid-catalyzed Synthesis of Pyrano[4,3-b]pyran-5(4H)-ones using 4,4,4-trifluoro-1-phenylbutane-1,3-dione as a Building Block.

Aims: synthesis of pyrano[c-2,3]chromens with Ionic Liquid catalyst with simple method.

Background: Synthesis of pyrano[c]coumarins has a special place in the structure due to two bioactive compounds in its structure and attracts a great deal of attention in this research work, it has been attempted to attach chromatically valuable skeletons to them and synthesize the pyrano [c] coumarines, which can potentially have high biological properties. For this purpose, electrophilic β-ketoester ringing in the presence of ionic liquid catalysts was used.

Grinding Synthesis of Pyrazolyl-Bis Coumarinyl Methanes Using Potassium 2-Oxoimidazolidine-1,3-diide.

Aim And Objective: Potassium 2-oxoimidazolidine-1,3-diide (POImD) as a novel and reusable catalyst was used for the synthesis of pyrazolyl-bis coumarinyl methanes by a nucleophilic addition reaction of synthetized pyrazolecarbaldehyde and two equivalents of 4-hydroxycoumarin under grinding. The catalyst can be reused and recovered several times without loss of activity. This method provides several advantages such as eco-friendliness, simple work-up and shorter reaction time as well as excellent yields.

"2-Amino glucose" as a substrate for synthesis of magnetically recoverable nanocatalyst NiFeO@SiO@amino glucose for the green synthesis of novel bis (1,2-dihydro-4-hydroxy-2-oxoquinolin-3-yl)methanes.

2-Amino glucose ((2S,3R,4S,5S,6R)-2-amino-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol) as a substrate for the synthesis of NiFeO@SiO@amino glucose supply an environmentally friendly procedure for the synthesis of bis(1,2-dihydro-4-hydroxy-2-oxoquinolin-3-yl)methanes through one-pot condensation of aldehyde or pyrazolo carbaldehyde and two equivalents of 4-hydroxyquinolin-2(1H)-ones in aqueous media. Eco-friendliness, high purity of the desired products, short reaction time and easy workup procedure can be mentioned as the other advantages of this method. The structures of the synthesized 4-hydroxy-2(1H)-quinolone compounds were confirmed by H, C NMR and FTIR spectral data and elemental analyses.

Recent advances in the application of nano-catalysts for Hiyama cross-coupling reactions.

This mini-review highlights the recent developments in the field of metal nanoparticle (NP) catalyzed Hiyama cross-coupling reactions. Most of the nanocatalysts outlined here allow convenient and green synthetic pathways for the construction of carbon-carbon bonds in water and fluoride-free conditions. Literature has been surveyed from 2005 to February 2018.

Synthesis and characterization of amino glucose-functionalized silica-coated NiFeO nanoparticles: a heterogeneous, new and magnetically separable catalyst for the solvent-free synthesis of pyrano[3,2-]chromen-5(4)-ones.

A novel, efficient and one-pot multi-component procedure for the synthesis of simple pyrano[3,2-]chromen-5(4)-ones or pyrazolyl pyrano[3,2-]chromen-5(4)-ones reaction of aryl aldehydes, acetophenones and 4-hydroxycoumarin promoted by amino glucose-functionalized silica-coated NiFeO nanoparticles under solvent-free conditions without using any other harmful organic reagents was reported. The structure of this nanoparticle was characterized by transmission electron microscopies, X-ray diffraction and Fourier transform infrared spectroscopies. The catalyst could easily be separated from the reaction mixture by using an external magnetic field and it was reusable.

Cross-Dehydrogenative Coupling Reactions Between P(O)-H and X-H (X = S, N, O, P) Bonds.

P(O)-X (X = S, N, O, P) bond-containing compounds have extensive application in medicinal chemistry, agrochemistry, and material chemistry. These useful organophosphorus compounds also have many applications in organic synthesis. In light of the importance of titled compounds, there is continuing interest in the development of synthetic methods for P(O)-X bonds construction.

Diaryl ethers synthesis: nano-catalysts in carbon-oxygen cross-coupling reactions.

The diaryl ether moiety is not only prevalent in a significant number of natural products and synthetic pharmaceuticals but also widely found in many pesticides, polymers, and ligands. Ullmann-type cross-coupling reactions between phenols and aryl halides are regarded as one of the most important methods for the synthesis of this important and versatile structural motif. In recent years, the use of nano-sized metal catalysts in this coupling reaction has attracted a lot of attention because of these catalysts with their high surface-to-volume ratio, high surface energy, and reactive morphology allows for rapid C-O bond formation under mild and ligand-free conditions.

One-pot Synthesis of Novel 2-pyrazolo-3-phenyl-1,3-thiazolidine-4-ones Using DSDABCOC as an Effective Media.

Background: Thiazolidine compounds are known to show interesting pharmacological activity. In particular, they are used as antiseizure, fungicidal, anti-bacterial, antitubercular, antiinflammatory, antiamoebic, anti-diabetic and local anesthetic agents. Some of these compounds have also shown antiparkinsonism, antioxidant, anticonvulsant, hypoglycemic and non-narcotic analgesic activities.

Fe3O4@SiO2@KIT-6 as an Efficient and Reusable Catalyst for the Synthesis of Novel Derivatives of 3,3'-((Aryl-1-phenyl-1H-pyrazol-4- yl)methylene)bis (1H-indole).

Aim And Objective: Korea advanced institute of science and technology cubic ordered mesoporous silica (KIT-6 mesoporous) silica coated magnetite nanoparticles, is an effective, ecobenign and recyclable catalyst for the electrophilic substitution reactions of indoles with various synthetized aldehydes to afford the corresponding novel diindolylmethanes in high yields and short reaction times. The catalyst can be recovered and reused without loss of activity. The work-up of the reaction consists of a simple separation, followed by concentration of the crude product and purification.

An efficient and green synthesis of novel benzoxazole under ultrasound irradiation.

Ultrasound as green process and an alternative energy source was investigated for the environmentally benign synthesis of novel benzoxazoles from different azo-linked salicylic acid derivatives and 2-amino-4-chlorophenol in short reaction time and high yield. These benzoxazole compounds have been characterized by elemental analysis, FT-IR, (1)H NMR and (13)C NMR spectroscopy.

Ultrasound-promoted regio and chemoselective synthesis of pyridazinones and phthalazinones catalyzed by ionic liquid [bmim]Br/AlCl3.

The first ultrasound-promoted multicomponent synthesis of pyridazinones and phthalazinones from arenes, cyclic anhydrides and ArNHNH(2) in the presence of an efficient recyclable catalyst, [bmim]Br/AlCl(3), in high yield and short reaction time is reported.

A convenient ultrasound-promoted regioselective synthesis of fused polycyclic 4-aryl-3-methyl-4,7-dihydro-1H-pyrazolo[3,4-b]pyridines.

Fused polycyclic 4-aryl-3-methyl-4,7-dihydro-1H-pyrazolo[3,4-b]pyridines were obtained in a three-component regioselective reaction of 5-amino-3-methyl-1H-pyrazole, 2H-indene-1,3-dione and arylaldehydes in ethanol under ultrasound irradiation. This rapid method produced the products in short reaction times (4-5min) and excellent yields (88-97%).

An efficient one-pot three-component synthesis of fused 1,4-dihydropyridines using HY-zeolite.

A facile and convenient protocol was developed for the fast (2.5-3.5 h) and high yielding (70-90%) synthesis of fused 1,4-dihydropyridines from dimedone in the presence of HY-zeolite as an efficient recyclable heterogeneous catalyst.

KSF: an efficient catalyst for the regioselective synthesis of 1,5-diaryl pyrazoles using Baylis-Hillman adducts.

A facile and convenient protocol was developed for the regioselective synthesis of 1,5-diarylpyrazoles using Baylis-Hillman adducts over KSF catalyst in high yields (70-90%) and low reaction times.