Publications by authors named "Mohammad Navid Mohammadian"
Chem Biodivers
September 2024
Article Synopsis
- Twelve new 3,4-dihydropyrimidine derivatives were created using a Biginelli reaction, and their effectiveness against cancer cells (MCF-7, A549, and HeLa) was tested.
- Compound 5l, which has a 4-Cl-phenyl group, showed the highest potency against A549 cells, suggesting modifications at the C4 position improve cytotoxicity.
- Molecular studies indicated that the R enantiomer of compound 5l binds more effectively to the Eg5 enzyme than the S enantiomer, potentially enhancing its anti-cancer properties.
