Viscoelastic Behavior of Cellular Biomaterials Based on Octet-Truss and Tetrahedron Topologies.

Cellular biomaterials offer unique properties for diverse biomedical applications. However, their complex viscoelastic behavior requires careful consideration for design optimization. This study explores the effective viscoelastic response of two promising unit cell designs (tetrahedron-based and octet-truss) suitable for high porosity and strong mechanics.

A supervised learning-assisted multi-scale study for thermal and mechanical behavior of porous Silica.

This paper presents a comprehensive investigation of mesoporous Silica utilizing a multi-scale modeling approach under periodic boundary conditions integrated with machine learning algorithms. The study begins with Molecular Dynamics (MD) simulations to extract Silica's elastic properties and thermal conductivity at the nano-scale, employing the Tersoff potential. Subsequently, the derived material characteristics are applied to a series of generated porous Representative Volume Elements (RVEs) at the microscale.

On the soft tissue ultrasound elastography using FEM based inversion approach.

Elastography is a medical imaging modality that enables visualization of tissue stiffness. It involves quasi-static or harmonic mechanical stimulation of the tissue to generate a displacement field which is used as input in an inversion algorithm to reconstruct tissue elastic modulus. This paper considers quasi-static stimulation and presents a novel inversion technique for elastic modulus reconstruction.

Application of artificial neural networks to predict Young's moduli of cartilage scaffolds: An in-vitro and micromechanical study.

In this study, four-phase Gelatin-Polypyrrole-Akermanite-Magnetite scaffolds were fabricated and analyzed using in-vitro tests and numerical simulations. Such scaffolds contained various amounts of Magnetite bioceramics as much as 0, 5, 10, and 15 wt% of Gelatin-Polypyrrole-Akermanite biocomposite. X-ray diffraction analysis and Fourier transform infrared spectroscopy were conducted.

Effect of magnetite nanoparticles on the biological and mechanical properties of hydroxyapatite porous scaffolds coated with ibuprofen drug.

Gelatin (GN) is a polymer, which is similar to the protein derived from collagen, an organic element in the bone. GN can incorporate into the mineral part of the bone, hydroxyapatite (HA). The HA bioceramic has properties very close to the natural bone characteristics.

A novel magnetic bifunctional nanocomposite scaffold for photothermal therapy and tissue engineering.

In recent years, porous bifunctional scaffolds with hyperthermal and tissue regeneration functions play an essential role in the efficient cancerous bone tumors treatment. In this work, the nanocomposite scaffolds of gelatin (polymer phase) and akermanite (ceramic phase) were prepared by entrapping carboxyl-functionalized multi-walled carbon nanotube (MWNT) and embedding magnetic nanoparticles of iron oxide into the porous matrix as photothermal conversion agents. The obtained scaffolds and their components were characterized using FTIR, FESEM, TEM, EDS, DLS, and VSM analysis.

Influence of MgO nanoparticles on the mechanical properties of coated hydroxyapatite nanocomposite scaffolds produced via space holder technique: Fabrication, characterization and simulation.

In the current study, hydroxyapatite (HA)-MgO scaffolds are fabricated with the aid of the space holder technique using NaCl as the spacer type. After that, the fabricated samples are deposited in gelatin (GN) with ibuprofen (IBO) substitution to create GN-IBO thin surface coating. The samples are then synthesized chemically and the associated properties are studied using X-ray diffraction (XRD) and scan electron microscopy (SEM) equipped with the energy dispersive spectroscopy (EDS).

Mechanical Properties of Additively Manufactured Thick Honeycombs.

Honeycombs resemble the structure of a number of natural and biological materials such as cancellous bone, wood, and cork. Thick honeycomb could be also used for energy absorption applications. Moreover, studying the mechanical behavior of honeycombs under in-plane loading could help understanding the mechanical behavior of more complex 3D tessellated structures such as porous biomaterials.

Comparison of elastic properties of open-cell metallic biomaterials with different unit cell types.

Additive manufacturing techniques have made it possible to create open-cell porous structures with arbitrary micro-geometrical characteristics. Since a wide range of micro-geometrical features is available for making an implant, having a comprehensive knowledge of the mechanical response of cellular structures is very useful. In this study, finite element simulations have been carried out to investigate the effect of structure unit cell type (cube, rhombic dodecahedron, Kelvin, Weaire-Phelan, and diamond), cross-section type (circular, square, and triangular), strut length, and relative density on the Young's modulus, shear modulus, yield stress, shear yield stress, and Poisson's ratio of open-cell tessellated cellular structures.