Objectives: The aim of this study was to determine the effect of MTAD on the expression of virulence factors of Enterococcus faecalis (E.faecalis) considering the role of Guttapercha/AH26 or Resilon/RealSeal SE as root canal obturating materials.
Materials And Methods: One-hundred and forty-four single-rooted human teeth were instrumented to a standardized apical size.