The Relationship between Left Ventricular Diastolic Function Parameters and Coronary Artery Disease Severity.

Background: The relationship between diastolic function parameters and the severity of coronary artery disease (CAD) is controversial. This study aimed to determine the relationship between left ventricular diastolic function and the severity of CAD.

Methods: This cross-sectional study included 63 patients with Ischemic heart disease (IHD) or those suspected of having IHD, who underwent angiography.

Cysteamine-Anchored MOF through Post-Synthetic Modification Strategy for the Effective Removal of Mercury from Water.

The introduction of cysteamine functionality, referred to as Q-ZIF-67-SH, was successfully achieved through postsynthetic modification while maintaining the structural and thermal stability of the quasi metal-organic framework Q-ZIF-67. By subjecting ZIF-67 to controlled partial deligandation at 310 °C under an air atmosphere, a substantial number of unsaturated cobalt sites were generated within the quasi ZIF-67 (Q-ZIF-67) structure. These unsaturated cobalt sites facilitated effective coordination with cysteamine, resulting in the development of the thiol-functionalized framework Q-ZIF-67-SH.

Defect-Engineered Metal-Organic Framework/Polyimide Mixed Matrix Membrane for CO Separation.

Defect-engineered metal-organic frameworks (MOFs) with outstanding structural and chemical features have become excellent candidates for specific separation applications. The introduction of structural defects in MOFs as an efficient approach to manipulate their functionality provides excellent opportunities for the preparation of MOF-based mixed matrix membranes (MMMs). However, the use of this strategy to adjust the properties and develop the separation performance of gas separation membranes is still in its early stages.

Quasi-HKUST Prepared via Postsynthetic Defect Engineering for Highly Improved Catalytic Conversion of 4-Nitrophenol.

HKUST-1 [Cu(BTC)(HO)]·HOMeOH was submitted to thermolysis under controlled conditions at temperatures between 100 and 300 °C. This treatment resulted in partial ligand decarboxylation, generating coordinatively unsaturated Cu sites with extra porosity on the way to the transformation of the initial HKUST-1 framework to CuO. The obtained materials retaining in part the HKUST-1 original crystal structure (quasi-MOFs) were used to promote 4-nitrophenol conversion to 4-aminophenol.

Improved catalytic hydrogen release of quasi HKUST-1 compared to HKUST-1.

On-demand hydrogen release could be an important process for the transportation of fuel in the near future. Herein it is reported that the controlled thermolysis of HKUST-1 under optimal conditions generates structural defects resulting in a quasi-HKUST-1 material showing a 20-fold enhancement of the H release turnover frequency at room temperature in the absence of a base.

Enhanced Catalytic Performance of Quasi-HKUST-1 for the Tandem Imine Formation.

Copper-based metal-organic framework (Cu (BTC) (H O) ] ⋅nH OMeOH (HKUST-1) has been subjected to thermolysis under air atmosphere at different temperatures ranging from 100 to 300 °C. This treatment produces the partial removal of ligands, the generation of structural defects and additional porosity in a controlled way. The resulting defective materials denoted according to the literature as quasi-MOFs, were subsequently employed as heterogeneous catalysts in the one pot synthesis of N-benzylideneaniline from aniline and benzyl alcohol in open air as terminal oxidant at 70 °C under base- and dehydrating agent-free conditions.

Sensitive Ratiometric Fluorescent Metal-Organic Framework Sensor for Calcium Signaling in Human Blood Ionic Concentration Media.

A two-dimensional fluorescent metal-organic framework (MOF) sensor, TMU-5S, was synthesized by introducing rhodamine B into the framework of TMU-5. This dye-sensitized MOF was explored as a ratiometric fluorescent sensor for Ca signaling in the presence of interfering cations in ionic concentrations similar to that of blood plasma that exhibits exceptional sensitivity and selectivity to Ca and faster response and recovery times than any other reported fluorescent sensor. This can be attributed to strong electrostatic interactions between basic azine groups in the narrow pore walls of TMU-5S and Ca as hard-hard acid-base interactions.

Mixed-Metal MOFs: Unique Opportunities in Metal-Organic Framework (MOF) Functionality and Design.

Mixed-metal metal-organic frameworks (MM-MOFs) can be considered to be those MOFs having two different metals anywhere in the structure. Herein we summarize the various strategies for the preparation of MM-MOFs and some of their applications in adsorption, gas separation, and catalysis. It is shown that compared to homometallic MOFs, MM-MOFs bring about the opportunity to take advantage of the complexity and the synergism derived from the presence of different metal ions in the structure of MOFs.

Host-Guest Interaction Optimization through Cavity Functionalization for Ultra-Fast and Efficient Water Purification by a Metal-Organic Framework.

To achieve optimized host-guest interactions, a "cavity functionalization" approach has been applied using two isostructure MOFs, [Zn(OBA)(BPDB)] ·2DMF (TMU-4) and [Zn(OBA)(HDPT)] ·DMF (TMU-34), where HOBA = 4,4'-oxybis(benzoic acid), BPDB = 1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene, and HDPT = 3,6-di(pyridin-4-yl)-1,4-dihydro-1,2,4,5-tetrazine. TMU-4 and TMU-34 are functionalized with azine and dihydro-tetrazine groups, respectively. Both of these functions can act as Lewis basic sites, but only the dihydro-tetrazine function inside the cavities of TMU-34 can act as a hydrogen bond donor site.

Comparison of serum levels of IL-6, IL-8, TGF-β and TNF-α in coronary artery diseases, stable angina and participants with normal coronary artery.

Cytokines, which typically regulate the immune responses, play a role in cardiovascular diseases such as coronary artery diseases (CAD) and ischemic heart diseases (IHD). The aims of this study were to evaluate serum levels of IL-6, IL-8, TGF-β and TNF-α in patients with or without CAD, as well as stable angina, and to assess the effects of drug administration on the serum levels of these cytokines. Serum levels of the cytokines were analyzed in the three groups: patients with acute coronary syndrome, stable angina and participants with normal coronary arteries as controls.

Sonochemical synthesis and structural characterization of a new Zn(II) nanoplate metal-organic framework with removal efficiency of Sudan red and Congo red.

A 3-D Zn(II) based metal-organic framework (MOF) of [Zn(oba)(DMF)] was synthesized using the nonlinear dicarboxylate ligand, 4,4'-oxybis(benzoic acid) (Hoba) via sonochemical and solvothermal routes. IR spectroscopy, single-crystal X-ray crystallography, scanning electron microscopy, and X-ray powder diffraction were used to characterize these MOF samples. The effect of different times of irradiation and various concentrations of primary reagents were experimented for obtaining monotonous morphology.

Ultrasound-assisted synthesis and characterization of a new metal-organic framework based on azobenzene-4,4-dicarboxylic acid: Precursor for the fabrication of CoO nano-particles.

Azobenzene groups are widely known as photochromic ligands thus are particularly interesting building blocks for designing receptors for neutral or charged guests. A new metal-organic framework, [Co(adc)(DMF)].2DMF (compound 1) (adc = azobenzene-4,4-dicarboxylic acid, DMF = N,N-dimethylformamide), was synthesized by solvothermal methods and structurally characterized using X-ray crystallography and a range of spectroscopic techniques.

A nanocomposite prepared from a zinc-based metal-organic framework and polyethersulfone as a novel coating for the headspace solid-phase microextraction of organophosphorous pesticides.

The authors describe a zinc-based metal-organic framework/polyethersulfone nanocomposite (TMU-4/PES) coating deposited on a stainless steel wire via a single-phase inversion method. The nanocomposite represents a novel fiber coating for headspace solid-phase microextraction of organophosphorous pesticides (OPPs) from environmental water and soil samples. The synergistic effects of the high surface area and unique porous structure of TMU-4 as well as the rich π electron stacking and mechanical attributes of the PES polymer result in a high affinity of the composite for OPPs.

Morphology-dependent sensing performance of dihydro-tetrazine functionalized MOF toward Al(III).

A pillared MOF, [Zn(OBA)(HDPT)].DMF (TMU-34), based on dihydro tetrazine functionalized pillar spacer (HDPT=3,6-di(pyridin-4-yl)-1,4-dihydro-1,2,4,5-tetrazine) and V-shape dicarboxylate linker (HOBA=4,4'-oxybis(benzoic acid)) was synthesized by reflux and ultrasonic methods. The effects of sonication time, initial concentration of reagents and sonication power on size and morphology have been optimized.

Double Solvent Sensing Method for Improving Sensitivity and Accuracy of Hg(II) Detection Based on Different Signal Transduction of a Tetrazine-Functionalized Pillared Metal-Organic Framework.

To design a robust, π-conjugated, low-cost, and easy to synthesize metal-organic framework (MOF) for cation sensing by the photoluminescence (PL) method, 4,4'-oxybis(benzoic acid) (HOBA) has been used in combination with 3,6-di(pyridin-4-yl)-1,2,4,5-tetrazine (DPT) as a tetrazine-functionalized spacer to construct [Zn(OBA)(DPT)]·DMF (TMU-34(-2H)). The tetrazine motif is a π-conjugated, water-soluble/stable fluorophore with relatively weak σ-donating Lewis basic sites. These characteristics of tetrazine make TMU-34(-2H) a good candidate for cation sensing.

Residual stress measurements via neutron diffraction of additive manufactured stainless steel 17-4 PH.

Neutron diffraction was employed to measure internal residual stresses at various locations along stainless steel (SS) 17-4 PH specimens additively manufactured via laser-powder bed fusion (L-PBF). Of these specimens, two were rods (diameter=8 mm, length=80 mm) built vertically upward and one a parallelepiped (8×80×9 mm) built with its longest edge parallel to ground. One rod and the parallelepiped were left in their as-built condition, while the other rod was heat treated.

Stimuli-Responsive Metal-Organic Framework (MOF) with Chemo-Switchable Properties for Colorimetric Detection of CHCl.

The ligands 3,6-di(pyridin-4-yl)-1,4-dihydro-1,2,4,5-tetrazine (H DPT), as a pillar spacer, and 4,4'-oxybis(benzoic acid) (H OBA), as a dicarboxylate linker, have been used to develop a dihydrotetrazine-functionalized pillared metal-organic framework (MOF), [Zn(OBA)(H DPT) ]⋅DMF (TMU-34), as a functionally convertible stimuli-responsive MOF-based sensor. Sonochemically synthesized TMU-34 powder has been employed in the sensing of volatile organic compounds (VOCs). The results show that TMU-34 can act as a solid-state, naked-eye visual chemosensor for the detection of chloroform in the liquid and gas phases.

Ultrasonic assisted synthesis of a tetrazine functionalized MOF and its application in colorimetric detection of phenylhydrazine.

TMU-34(-2H), [Zn(OBA)(DPT)].DMF, has been sonochemically synthesized by applying HOBA, (4,4'-oxybis(benzoic acid)), as the dicarboxylate linker, and DPT, (3,6-di(pyridin-4-yl)-1,2,4,5-tetrazine), as pillar spacer. Sonication time, concentration of initial reagents, sonication power and molar ratio of pyridine as modulator has been optimized to synthesize nano powder of TMU-34(-2H) including uniform plate morphology.

Porosity and dye adsorption enhancement by ultrasonic synthesized Cd(II) based metal-organic framework.

A Cd(II) based metal-organic framework, TMU-7, was synthesized by incorporation of V-shaped flexible dicarboxylate ligand and the N-donor pillar ligand using sonochemical method while morphology and size of particles were investigated and characterized by scanning electron microscopy and X-ray powder diffraction. Moreover, N adsorption was applied to examine the effect of synthesis method on porosity. Also TMU-7 was evaluated for its Congo red adsorption.

High organic sulfur removal performance of a cobalt based metal-organic framework.

Synthesis of a new porous cobalt based metal-organic framework, [Co(oba)(CHO)(O)]n·3DMF (TMU-11) has been carried out to introduce a new and highly efficient adsorbent of dibenzothiophene (DBT). This compound has been synthesized by solvothermal method using a nonlinear dicarboxylate ligand and characterized by single-crystal X-ray crystallography. To study the adsorption properties of the synthesized compound, TMU-11, for DBT removal, various factors, such as amount of adsorbent, contact time and temperature were examined.

Improvement of Methane-Framework Interaction by Controlling Pore Size and Functionality of Pillared MOFs.

The rational design of functionalized porous metal-organic frameworks (MOFs) for gas adsorption applications has been applied using three spacer ligands HDPT (3,6-di(pyridin-4-yl)-1,4-dihydro-1,2,4,5-tetrazine), DPT (3,6-di(pyridin-4-yl)-1,2,4,5-tetrazine), and BPDH (2,5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene) to synthesize TMU-34, [Zn(OBA)(HDPT)]·DMF, TMU-34(-2H), [Zn(OBA)(DPT)]·DMF, and TMU-5, [Zn(OBA)(BPDH)]·1.5DMF, respectively. By controlling the pore size and chemical functionality of these three MOFs, we can improve the interactions between CO and especially CH with the frameworks.

Ultrasonic assisted synthesis of two new coordination polymers and their applications as precursors for preparation of nano-materials.

Two new isostructural coordination polymers, [Zn(Oba)][MeNH)]·6DMF·3HO (1) and [Cd(Oba)][MeNH)]·2DMF·2HO (2), were synthesized using the nonlinear dicarboxylate ligand, 4,4'-oxybis(benzoic acid) (Hoba) and characterized by IR spectroscopy and single-crystal X-ray crystallography. Single-crystal X-ray data show that 1 and 2 are two-dimensional coordination polymers that can be extended to three-dimensional supramolecular networks by CH…O interactions. These two new coordination polymers were also sonochemically synthesized while sonication time and power of irradiation influencing size and morphology of nano-structured compounds were also studied.

Two Dimensional Host-Guest Metal-Organic Framework Sensor with High Selectivity and Sensitivity to Picric Acid.

A dye-sensitized metal-organic framework, TMU-5S, was synthesized based on introducing the laser dye Rhodamine B into the porous framework TMU-5. TMU-5S was investigated as a ratiometric fluorescent sensor for the detection of explosive nitro aromatic compounds and showed four times greater selectivity to picric acid than any state-of-the-art luminescent-based sensor. Moreover, it can selectively discriminate picric acid concentrations in the presence of other nitro aromatics and volatile organic compounds.

High adsorption capacity of two Zn-based metal-organic frameworks by ultrasound assisted synthesis.

Micro- and nano-rods and plates of two 3D, porous Zn(II)-based metal-organic frameworks [Zn(oba)(4-bpdh)0.5]n·(DMF)1.5 (TMU-5) and [Zn(oba)(4-bpmb)0.

Elevated Plasma Homocysteine Concentration in Opium-Addicted Individuals.

Background: Although the triggering role of both opium use and elevated plasma homocysteine level for progressing atherosclerosis and, therefore, appearing coronary heart disease has been clearly determined, no study are available with respect to the relation between these to risk profiles. In the present study and for the first time, we hypothesized that the opium addiction can be potentially correlated with elevated homocysteine concentration.

Methods: 217 persons (103 opium-addicted and 114 non-addicted) were randomly selected from the Kerman Coronary Artery Disease Risk Study (KERCADRS), Iran, as a population-based, epidemiological prospective study.