Correlation of Novel Single Nucleotide Polymorphisms of and Genes with Male Infertility in North West of Iran.

Background: Observational studies that inspected the association of and novel single nucleotide polymorphism (SNP) with odds of male infertility are sparse. Male infertility prevalence in Iran is reported more than global prevalence, while about 30-50% of infertile male have no distinct reason yet and they are considered as idiopathic male infertility. This study was conducted to investigate association of different SNPs of and genes with male infertility among the Iranian population.

Curcumin Can be Acts as Effective agent for Prevent or Treatment of Alcohol-induced Toxicity in Hepatocytes: An Illustrated Mechanistic Review.

Previous studies have shown that alcohol abuse can cause serious liver damage and cirrhosis. The main pathway for these types of hepatocellular cell neurodegeneration is mitochondrial dysfunction, which causes lipid peroxidation and dysfunction of the glutathione ring and the defect of antioxidant enzymes in alcoholic hepatic cells. Alcohol can also initiate malicious inflammatory pathways and trigger the initiation and activation of intestinal and extrinsic apoptosis pathways in hepatocellular tissues that lead to cirrhosis.