Publications by authors named "Mohammad Malekan"
Article Synopsis
- - Actinic prurigo is a rare skin condition that causes itchy, raised lesions and is particularly difficult to treat, especially in children.
- - Effective management requires strict sun protection, as symptoms can last for most of the year.
- - A case study of an 8-year-old patient showed quick improvement of symptoms using baricitinib, a medication not commonly used for this condition.
Melanoma is responsible for most skin cancer-associated deaths globally. The progression of melanoma is influenced by a number of pathogenic processes. Understanding the VEGF/VEGFR axis, which includes VEGF-A, PlGF, VEGF-B, VEGF-C, and VEGF-D and their receptors, VEGFR-1, VEGFR-2, and VEGFR-3, is of great importance in melanoma due to its crucial role in angiogenesis.
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- - The review discusses the role of brain-derived neurotrophic factor (BDNF) in cancer, highlighting its potential to promote cancer cell growth and migration through specific receptor pathways like TrkB and p75NTR.
- - Studies show that BDNF is overexpressed in several cancers ( prostate, lung, and breast), which is associated with poorer patient outcomes, suggesting that measuring BDNF levels could help in disease diagnosis and treatment response prediction.
- - Current clinical research is focused on targeting BDNF receptors and their signaling pathways with various agents to potentially mitigate their oncogenic effects, but further trials are needed to thoroughly understand BDNF's role in cancer and explore it as a therapeutic target.
Article Synopsis
- Glioblastoma (GBM) is the most common type of brain tumor in adults, characterized by a very low survival rate of less than 7% over five years.
- Current treatments focusing on specific cell metabolism have largely failed to improve patient outcomes.
- Understanding the intricate communication between GBM cells and their surrounding environment could lead to new therapeutic strategies and improve prognosis for patients.
Breast cancer [BC] is one of the most common cancers among women, one of the leading causes of a considerable number of cancer-related death globally. Among all procedures leading to the formation of breast tumors, angiogenesis has an important role in cancer progression and outcomes. Therefore, various anti-angiogenic strategies have been developed so far to enhance treatment's efficacy in different types of BC.
View Article and Find Full Text PDFThe process of material cutting emerges from a series of nonlinear phenomena including frictional contact, plastic deformation, and fracture. While cutting dominated by shear deformation is of interest to achieve a smooth material removal and a high-quality surface finish, the fracture-induced chip breaking is of equal importance to prevent the formation of long chips. Here we show that discrepant observations and predictions of these two distinct cutting mechanisms can be reconciled into a unified framework.
View Article and Find Full Text PDFBackground: Evidence recommends that vitamin D might be a crucial supportive agent for the immune system, mainly in cytokine response regulation against COVID-19. Hence, we carried out a systematic review and meta-analysis in order to maximise the use of everything that exists about the role of vitamin D in the COVID-19.
Methods: A systematic search was performed in PubMed, Scopus, Embase and Web of Science up to December 18, 2020.
Background: The outbreak of the coronavirus disease-2019 (COVID-19) has become a global public health challenge. Assessing the effect of COVID-19 on liver injury is of great importance. A systematic review and meta-analysis were conducted to establish the characteristics of liver function tests in COVID-19 patients.
View Article and Find Full Text PDFThe role of Hypoxia-Inducible Factor-1alpha and its signaling in melanoma.
Biomed Pharmacother
September 2021
Adaptation to the loss of O2 is regulated via the activity of hypoxia-inducible factors such as Hypoxia-Inducible Factor-1 (HIF-1). HIF-1 acts as a main transcriptional mediator in the tissue hypoxia response that regulates over 1000 genes related to low oxygen tension. The role of HIF-1α in oncogenic processes includes angiogenesis, tumor metabolism, cell proliferation, and metastasis, which has been examined in various malignancies, such as melanoma.
View Article and Find Full Text PDFFull genome characterization of Iranian H5N8 highly pathogenic avian influenza virus from Hooded Crow (Corvus cornix), 2017: The first report.
Comp Immunol Microbiol Infect Dis
June 2019
During 2014-2017 Clade 2.3.4.
View Article and Find Full Text PDFSince 1998, Iran's poultry industry has faced several outbreaks of low pathogenic avian influenza H9N2. Tissue samples were collected from a broiler flock with respiratory symptoms in autumn 2017. After that, virus isolation and confirmation of H9N2 using RT-PCR, sequencing, and bioinformatic analysis for all eight genes were performed.
View Article and Find Full Text PDFBackground And Objectives: Urinary tract infections (UTI) caused by enterohemorrhagic Escherichia coli (EHEC) is one of the most important diseases in infants and children. If there would not be any useful diagnosis and treatment it may be resulted in diseases such as acute renal failure, thrombocytopenia and hemolytic anemia. The aim of this study was to determine frequency of verotoxigenic E.
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