The Effects of a Wearable Sensory Prosthesis on Gait and Balance Function After 10 Weeks of Use in Persons With Peripheral Neuropathy and High Fall Risk - The walk2Wellness Trial.

Background: Sensory peripheral neuropathy (PN) is associated with gait, balance problems and high fall risk. The walk2Wellness trial investigates effects of long-term, home-based daily use of a wearable sensory prosthesis on gait function, balance, quality of life and fall rates in PN patients. The device (Walkasins, RxFunction Inc.

Effect of diabetes type on long-term outcome of epidermal axon regeneration.

Objective: To assess the effect of diabetes type on the long-term rate and extent of epidermal nerve regeneration.

Methods: Subjects with well controlled type 1 diabetes mellitus (n = 11) or type 2 diabetes mellitus (n = 36), with normal nerve conduction studies and baseline intraepidermal nerve fiber density (IENFD), and healthy controls (n = 10) underwent chemical axotomy of the intraepidermal nerves at the thigh using topical capsaicin. Skin biopsies were performed at 30, 90, 150, and 180 days post-axotomy.

Preliminary Effectiveness of Auricular Point Acupressure on Chemotherapy-Induced Neuropathy: Part 2 Laboratory-Assessed and Objective Outcomes.

Purpose: To manage chemotherapy-induced neuropathy (CIN), this paper explores reliable and valid objectives measures to evaluate the treatment effects of auricular point acupressure (APA).

Design/method: This study was a repeated-measures one-group design. Participants received four weeks of APA to manage their CIN.

Preliminary Effectiveness of Auricular Point Acupressure on Chemotherapy-Induced Neuropathy: Part 1 Self-Reported Outcomes.

Purpose: To reduce chemotherapy-induced neuropathy (CIN)-a significant challenge among cancer patients following chemotherapy-we explored the effects of auricular point acupressure (APA), which involves needleless, acupuncture-like stimulation on specific ear points.

Design/method: This pilot study examined the effects of a 4-week APA intervention in the management of CIN. Descriptive analysis was used to examine the changes in study outcomes.

Electrophysiologic features of fibular neuropathy in childhood and adolescence.

Introduction: We studied patterns of nerve injury in pediatric common fibular (peroneal) neuropathy (CFN).

Methods: A retrospective analysis was performed on data from 53 children with CFN at a pediatric electromyography laboratory.

Results: Conduction block at the fibular head was present in 35% of patients.

Longitudinal Assessment of Small Fiber Neuropathy: Evidence of a Non-Length-Dependent Distal Axonopathy.

Importance: Few data are available on the natural history of small fiber neuropathy (SNF). Peripheral neuropathy typically follows a length-dependent pattern, leading us to hypothesize that patients with SFN would lose intraepidermal nerve fibers at the distal leg more quickly than at more proximal thigh sites.

Objective: To compare the longitudinal rate and pattern of intraepidermal nerve fiber density (IENFD) change in idiopathic SFN (iSFN), impaired glucose tolerance-associated SFN (IGT-SFN), and diabetes mellitus-associated SFN (DM-SFN).

Hypopituitarism caused by carotid cavernous fistula.

Here we report a 79-year-old woman who presented with a 7-day history of headache, nausea, vomiting, and was found to have proptosis and ptosis. Laboratory findings showed hyponatremia, hypocortisolism, secondary hypothyroidism and low follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels. CT angiography (CTA) showed a vascular lesion in sella causing a mass affect on the pituitary gland which proved to be a carotid cavernous fistula (CCF) by conventional angiography.

Effect of tactile stimulus frequency on time perception: the role of working memory.

In most models of interval timing, there is a central clock, which is considered to be highly protected from the effects of external stimuli. However, many studies have reported such effects and different theories are proposed to explain the observations. These include the effect of arousal, attention sharing, memory load and information processing on central clock as well as change in the speed of the pacemaker.

Independent coding of movement duration in a repetitive non-visually guided movement.

Temporal information is an embedded feature of our sensory and motor experiences. How is temporal information encoded in the brain? In the two-stage theory of timing, an explicit representation of timing is responsible for the movement initiation while movement duration is coded implicitly. We investigated the correlation of movement duration and amplitude in a repetitive one-dimensional non-visually guided movement to find out if temporal information could be coded independently from movement.

Involvement of nitric oxide system in enhancement of morphine-induced conditioned place preference by agmatine in male mice.

Agmatine recently has been suggested as a neurotransmitter, is able to interact with various effects of morphine like analgesia and dependence. In this study, the effects of agmatine on rewarding properties of morphine, and the possible involvement of nitric oxide (NO) system has been evaluated in an unbiased conditioned place preference (CPP) paradigm. Agmatine (1, 5 and 10mg/kg, i.

Kinesthetic memory in distance reproduction task: importance of initial hand position information.

The role of the initial hand position in planning and implementation of a goal-directed movement is a matter of debate. We designed a non-visually guided repetitive reaching movement task to investigate the role of proprioceptive information of the initial or end hand position in implementation of kinesthetic memory. The experimental design consisted four experiments.

Agmatine potentiates morphine-induced conditioned place preference in mice: modulation by alpha2-adrenoceptors.

The effects of agmatine, an endogenous polyamine metabolite formed by decarboxylation of L-arginine, and its combination with morphine on conditioned place preference (CPP) has been investigated in male mice. Our data show that subcutaneous administration of morphine (1-7.5 mg/kg) significantly increases the time spent in the drug-paired compartment in a dose-dependent manner.

Resistance of peripheral and sub-cortical somatosensory pathway to electrical noise.

The somatosensory system is vulnerable to large amounts of noise distortion. But how does the central nervous system distinguish the peripheral inputs which carry information to the brain from that which does not possess information? To address this question we studied the effect of electrical stimulation of the median nerve on tactile spatial frequency perception in healthy subjects and Parkinson's disease (PD) patients. Subjects were categorized in two groups (healthy and PD patients) and were asked to report if a test tactile frequency pattern (TFP) was the same as the reference TFP given to the other hand.

Effect of cyclosporin A on morphine-induced place conditioning in mice: involvement of nitric oxide.

Cyclosporin A is shown to attenuate antinociceptive effects of morphine, development and expression of morphine-induced tolerance and dependency via nitric oxide (NO) pathway. In the present study, the effect of systemic cyclosporin A on morphine-induced conditioned place preference (CPP) and the probable involvement of nitric oxide were assessed in mice. Our data showed that administration of morphine (1, 2.