Printed polylactic acid/akermanite composite scaffolds for bone tissue engineering; development and surface modification.

The susceptibility of bone tissues to various factors such as ageing, accidents, and diseases has led to extensive tissue engineering research focusing on bone tissues. Hence, this research also aims to determine the optimal amount of Akermanite (AK) addition to the polylactic acid scaffold for bone tissue engineering applications, as well as the effects of surface modification on its properties. The Akermanite was synthesized using the sol-gel method.

Surface modified of chitosan by TiO@MWCNT nanohybrid for the efficient removal of organic dyes and antibiotics.

Considering the increase in the discharge of industrial effluents containing dyes and antibiotic resistance as a consequence of increasing the prescription and easy distribution of antibiotic drugs at the global level, designing efficient, biodegradable and non-toxic absorbents is necessary to reduce environmental harm effects. Herein, we present a series of novel eco-friendly ternary hybrid nanocomposite hydrogels CS/TiO@MWCNT (CTM) composed of chitosan (CS), TiO, and multiwalled carbon nanotube (MWCNT) for removal of methylene blue (MB) and methyl orange (MO) and common antibiotic ciprofloxacin (CIP) in aqueous medium. The combination of MWCNT and TiO improves the physicochemical properties of CS hydrogel and increases the adsorption capacity toward pollutants in the presence of different loadings.

Preparation and characterization of CS/PAT/ MWCNT@MgAl-LDHs nanocomposite for Cd removal and 4-nitrophenol reduction.

The present study evaluated the performance of multiwalled carbon nanotube (MWCNT)@MgAl-layered double hydroxide (LDH) nanoparticles loaded on poly-2 aminothiazole (PAT)/chitosan (CS) matrix (CPML) to remove Cd ions from aqueous solution. The removal efficiency of modified CS/PAT with MWCNT@MgAl-LDHs was increased significantly compared to pure CS/PAT. The influence of heavy metal ion concentration, pH, temperature, adsorbent dosage, and contact time on the adsorption was examined.

Recent advances in chitosan-based nanocomposites for adsorption and removal of heavy metal ions.

Due to the high concentration of various toxic and dangerous pollutants, industrial effluents have imposed increasing threats. Among the various processes for wastewater treatment, adsorption is widely used due to its simplicity, good treatment efficiency, availability of a wide range of adsorbents, and cost-effectiveness. Chitosan (CS) has received great attention as a pollutant adsorbent due to its low cost and many -OH and -NH functional groups that can bind heavy metal ions.

Introducing a protic ionic liquid from aminoethyl piperazine and triflic acid immobilized on pectin as a reusable nanocatalyst for the selective Schmidt synthesis of nitriles.

Preparation of reusable protic ionic liquid, triflic acid-immobilized aminoethyl piperazine-modified pectin (Pec-AEP-TfOH), with excellent activity and selectivity in modified Schmidt synthesis of nitriles from aldehydes and Si(CH)N has been described. The structure of the catalyst was characterized using FT-IR, XRD, FE-SEM, EDX-mapping, and TGA-DTA. The reaction demonstrated a broad substrate scope for a variety of benzaldehyde derivatives with electron withdrawing/donating substituents and heterocyclic aldehydes with yields between 85 and 96 % at room temperature.

Cerium oxide nanoparticles: Synthesis methods and applications in wound healing.

Wound care and treatment can be critical from a clinical standpoint. While different strategies for the management and treatment of skin wounds have been developed, the limitations inherent in the current approaches necessitate the development of more effective alternative strategies. Advances in tissue engineering have resulted in the development of novel promising approaches for accelerating wound healing.

Bioactive and Biodegradable Polycaprolactone-Based Nanocomposite for Bone Repair Applications.

This study investigated the relationship between the structure and mechanical properties of polycaprolactone (PCL) nanocomposites reinforced with baghdadite, a newly introduced bioactive agent. The baghdadite nanoparticles were synthesised using the sol-gel method and incorporated into PCL films using the solvent casting technique. The results showed that adding baghdadite to PCL improved the nanocomposites' tensile strength and elastic modulus, consistent with the results obtained from the prediction models of mechanical properties.

Lithium metasilicate glass-ceramic fabrication using spark plasma sintering.

Background: The digital dentistry, requires materials with wo opposite properties of machining ability and also enough hardness. The main objective of this experimental study was to investigate the fabrication feasibility of the lithium metasilicate glass-ceramic in partially crystalized stated using the spark plasma sintering (SPS) method.

Materials And Methods: In this study, SPS for the first time was used to fabricate primary lithium metasilicate glass-ceramic (LMGC) blocks.

Chitosan-based composite films to remove cationic and anionic dyes simultaneously from aqueous solutions: Modeling and optimization using RSM.

Regarding the existence of cationic and anionic dyes in the water environment developing new and effective techniques to remove them simultaneously is essential. Herein, a chitosan/poly-2-aminothiazole composite film reinforced with multi-walled carbon nanotube-Mg Al-layered double hydroxide (CPML) was created, characterized, and used as an effective adsorbent for methylene blue (MB) and methyl orange (MO) dyes removal from the aquatic medium. The SEM, TGA, FTIR, XRD, and BET methods were used to characterize the synthesized CPML.

Comparative evaluation of incorporation calcium silicate and calcium phosphate nanoparticles on biomimetic dentin remineralization and bioactivity in an etch-and-rinse adhesive system.

Background: This study aimed to evaluate the remineralization potential and bioactivity of adhesives, containing amorphous calcium phosphate (ACP) and calcium silicate (CS) nanoparticles (NPs).

Material And Methods: In this study, dentin slices (n=60) were prepared and etched with phosphoric acid. Next, they were divided into two groups: pre- and post-immersion in a simulated body fluid (SBF) for three weeks.

The effect of polyethylene glycol on printability, physical and mechanical properties and osteogenic potential of 3D-printed poly (l-lactic acid)/polyethylene glycol scaffold for bone tissue engineering.

One of the challenges in critical size bone defect repairing is the use of a porous degradable scaffold with appropriate properties to the host tissue. Nowadays, the three-dimensional (3D) printing method can produce custom and personalized scaffolds and overcome the problems of traditional methods by controlling the porosity and dimensions of biomaterial scaffolds. In this study, polylactic acid/polyethylene glycol (PLA/PEG) scaffolds were prepared with different PEG percentages (0, 5, 10, 15 and 20 wt%) by fused deposition modeling (FDM) to optimize printability and achieve suitable physico-mechanical properties and also enhance cellular behavior for bone tissue engineering and actually, this study complements previous studies.

Fabrication of functional and nano-biocomposite scaffolds using strontium-doped bredigite nanoparticles/polycaprolactone/poly lactic acid via 3D printing for bone regeneration.

Bone tissue engineering is a field to manufacture scaffolds for bone defects that cannot repair without medical interventions. Ceramic nanoparticles such as bredigite have importance roles in bone regeneration. We synthesized a novel strontium (Sr) doped bredigite (Bre) nanoparticles (BreSr) and then developed new nanocomposite scaffolds using polycaprolactone (PCL), poly lactic acid (PLA) by the 3D-printing technique.

Electro-conductive 3D printed polycaprolactone/gold nanoparticles nanocomposite scaffolds for myocardial tissue engineering.

The human's heart cannot regenerate after a wound by itself. So myocardial tissue can be damaged, leading to acute inflammation and scar. To overcome this issue, three dimensional (3D) scaffolds with appropriate properties have been proposed.

Electrosprayed cefazolin-loaded niosomes onto electrospun chitosan nanofibrous membrane for wound healing applications.

Chronic wounds are among the most therapeutically challenging conditions, which are commonly followed by bacterial infection. The ideal approach to treat such injuries are synergistic infection therapy and skin tissue regeneration. In the recent decades, nanotechnology has played a critical role in eradicating bacterial infections by introducing several carriers developed for drug delivery.

Cationic, anionic and neutral polysaccharides for skin tissue engineering and wound healing applications.

Today, chronic wound care and management can be regarded as a clinically critical issue. However, the limitations of current approaches for wound healing have encouraged researchers and physicians to develop more efficient alternative approaches. Advances in tissue engineering and regenerative medicine have resulted in the development of promising approaches that can accelerate wound healing and improve the skin regeneration rate and quality.

Shear bond strength of orthodontic brackets on intact and demineralized enamel after application of resin infiltrant, fluoride varnish and casein phosphopeptide-amorphous calcium phosphate remineralizing agents: in-vitro study.

Objective: To evaluate the effects of remineralizing agents on the shear bond strength (SBS) of orthodontic brackets bonded to intact and demineralized enamel.

Material And Methods: In this in-vitro study, 160 human premolars were divided into 8 groups, including group 1 with intact enamel as the positive control, group 2 with demineralized enamel as the negative control, groups 3-5 treated with fluoride varnish, Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) and resin infiltrant on intact enamel, and groups 6-8 treated with the same agents on demineralized enamel. Brackets were bonded using the conventional method, and the samples were thermocycled.

Spectroscopic studies on the interaction of aspartame with human serum albumin.

In this work the binding of artificial sweetener aspartame with human serum albumin (HSA) was studied at physiological pH. Binding studies of aspartame (APM) with HSA are useful to understand APM -HSA interaction, mechanism and providing guidance for the application and design of new and more efficient artificial sweeteners. The interaction was investigated by spectrophotometric, spectrofluorometric competition experiment and circular dichroism (CD) techniques.

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis.

Skin is the body's first barrier against external pathogens that maintains the homeostasis of the body. Any serious damage to the skin could have an impact on human health and quality of life. Tissue engineering aims to improve the quality of damaged tissue regeneration.

Stem cell-based therapeutic strategies for corneal epithelium regeneration.

Any significant loss of vision or blindness caused by corneal damages is referred to as corneal blindness. Corneal blindness is the fourth most common cause of blindness worldwide, representing more than 5% of the total blind population. Currently, corneal transplantation is used to treat many corneal diseases.