Publications by authors named "Mohammad Khani-Eshratabadi"
Background Aims: Acute myeloid leukemia (AML) is classified as a hematologic malignancy characterized by the proliferation of immature blood cells within the bone marrow (BM), resulting in an aberrant and unregulated cellular growth. The primary therapeutic modalities for AML include chemotherapy and hematopoietic stem cell transplantation. However, it is important to note that these treatments are accompanied by important adverse effects and mortality rates.
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- Microvesicles (MVs) from human umbilical cord-derived mesenchymal stem cells (hUCMSCs) show promise as potential biomarkers and treatments for acute myeloid leukemia (AML), particularly affecting the KG-1 leukemic cell line.
- The study involved isolating and characterizing hUCMSC-derived MVs and then treating KG-1 cells with different concentrations, resulting in significant increases in apoptosis and autophagy-related gene expression.
- Findings suggest that hUCMSC-MVs can effectively induce cancer cell death pathways, pointing towards their potential as a novel therapeutic strategy for AML.