Formulation of lyophilized single vial kit of N-N-Ethylene-L-Dicysteine (EC) for labeling with Tc. II: Radiochemical and clinical evaluation as a renal tubular agent in comparison with Tc-MAG3.

A Technetium Tc labeled lyophilized single component kit of N-N-ethylene-I-dicysteine (EC) is developed to replace multiple step kit developed by others. The aim of study is to formulate a radionuclide that is easy to prepare, has rapid plasma clearance, produce high quality images and is an affective alternative to radioiodine labeled orthoiodohippurate, which has been remained the physiological 'gold standard' since long time. To achieve this goal, the systematically varied key parameters such as pH, the use of reducing agents, stabilizers and additives are optimized to obtain maximum radiochemical purity and optimum biodistribution in non human and human primates.