Pharmacokinetics of ciprofloxacin in normal rabbits and changes observed in induced dehydrated state.

The pharmacokinetics of ciprofloxacin following oral administration of a single dose of 20 mg/kg body weight was investigated in normal rabbits and changes were observed in water-deprived rabbits. High performance liquid chromatographic method was employed for the determination of plasma concentration of ciprofloxacin. The mean plasma concentration and AUC (0-t) and AUC (0-inf) were significantly different between normal and dehydrated rabbits (P<0.

Clinical evaluation and monitoring of adverse effects for fixed multidose combination against single drug therapy in pulmonary tuberculosis patients.

To evaluate the clinical and therapeutic value of 4 and 3 drug fixed dose combinations verses single drug formulations to treat pulmonary tuberculosis patients. The occurrence of adverse effects was also monitored. A total of 293 patients having sputum positive pulmonary tuberculosis were enrolled (Male: 187 and Female: 106).