Transmission regulating immune genes- a potential strategy to control vector borne disease.

Background Objectives: More than 1 million people die every year from vector-borne diseases, which constitute more than 17% of all infectious diseases. This study's primary focus is on the detailed evolutionary history and expression analysis of immune genes, one of the key gene families in the immune system of vectors that play a role in the regulation and interaction of parasites in vector bodies, particularly the mosquitoes that transmit malaria and dengue, significant vector borne disease.

Methods: The vector potentiality and participation of TLR genes in vector parasite interaction in the Indian context will be explained by the differential expression study of this potential gene family in Indian populations of vector species.

Design, synthesis, in silico molecular docking, and ADMET studies of quinoxaline-isoxazole-piperazine conjugates as EGFR-targeting agents.

In this paper, we report the synthesis of quinoxaline-isoxazole-piperazine conjugates. The anticancer activity was evaluated against three human cancer cell lines, including MCF-7 (breast), HepG-2 (liver), and HCT-116 (colorectal). The outcomes of the tested compounds 5d, 5e, and 5f have shown more potent activity when compared to the standard drug erlotinib.

Physico-chemical properties of the association of cetyltrimethylammonium bromide and bovine serum albumin mixture in aqueous-organic mixed solvents.

Herein, we have investigated the association behavior of bovine serum albumin (BSA) and cetyltrimethylammonium bromide (CTAB) using the conductivity method in HO and HO + organic mixed solvents at different temperatures. The association phenomenon was detected from the deviation of the conductivity changes with enhancing the surfactant concentration and changes of numerous physico-chemical properties, such as CMC, α, β and thermodynamic variables (∆G, ∆H and ∆S). The values of CMC for the CTAB + BSA system in 10 % (v/v) solvents follow the trend: CMC < CMC < CMC < CMC < CMC.

Immunoinformatic Approach to Contrive a Next Generation Multi-Epitope Vaccine Against Infections.

Achromobacter xylosoxidans, previously identified as , is a rod-shaped, flagellated, non-fermenting Gram-negative bacterium that has the ability to cause diverse infections in humans. As a part of its intrinsic resistance to different antibiotics, spp. is also increasingly becoming resistant to Carbapenems.

Reliability of transcranial sonography for assessment of brain midline shift in adult neurocritical patients: a systematic review and meta-analysis.

Introduction: The aim of this systematic review and meta-analysis was to determine the reliability of transcranial sonography as an alternative to computed tomography for evaluation of brain midline shift in adult neurocritical patients.

Evidence Aquisition: The PubMed, EMBASE, Cochrane Library, Scopus and Web of Science databases were searched. Original studies evaluating brain midline shift in adult neurocritical patients using both transcranial sonography and computed tomography were eligible.

The tissue specific regulation of miR22 expression in the lung and brain by ribosomal protein L29.

Endogenous miR22 is associated with a diverse range of biological processes through post-translational modification of gene expression and its deregulation results in various diseases including cancer. Its expression is usually tissue or cell-specific, however, the reasons behind this tissue or cell specificity are not clearly outlined till-date. Therefore, our keen interest was to investigate the mechanisms of tissue or cell-specific expression of miR22.

A genome-wide single nucleotide polymorphism scan reveals genetic markers associated with fertility rate in Chinese Jing Hong chicken.

The function of the sperm storage tubules is directly correlated with the fertility of laying hens. However, little is known about the molecular mechanisms regulating the fertility traits in chicken. To identify genetic markers associated with reproductive traits, we calculated fertility rate at 61 to 69 wk (51 D) of Jing Hong chickens parent generation as the phenotype and the genotype were detected by the chicken 600K Affymetrix Axiom High Density single nucleotide polymorphisms (SNP)-array.

Pre natal evaluation of heterotaxy syndrome by fetal echocardiography and correlating with autopsy.

Introduction: Heterotaxy syndrome/ isomerism is characterized by an abnormal symmetry of the viscera that are normally dissimilar due to abnormal lateralization of thoracic and abdominal viscera and is frequently associated with complex cardiac anomalies. Isomerism may be of right or left.

Materials And Methods: This article describes the morphological characteristics of heterotaxy and suggests an approach in evaluating the spectrum of abnormalities associated with this syndrome.

Impact of natural light on growth and biopigment profile of cyanobacteria Spirulina platensis.

Cyanobacteria are economically important microorganisms and good source of natural pigments such as chlorophyll, carotenoids and phycobilliproteins. The present research work showed the optimum combination of photophase and scotophase of Spirulina platensis on biomass and chlorophyll-a, carotenoids, phycocyanin, allophycocyanin, and phycoerythrin contents. The study revealed that among all six light conditions tested, the cultures placed at west facing window, receiving natural day light at temperature 30°C showed extremely significant higher biomass (O.