Astaxanthin-loaded PLGA nanoparticles inhibit survival of MKN-45 gastric cancer cell line by modulating JAK2/STAT3/mTOR/PI3K pathway.

Background/aims: Gastric cancer (GC) is a significant global health issue with high incidence rates and poor prognoses, ranking among the top prevalent cancers worldwide. Due to undesirable side effects and drug resistance, there is a pressing need for the development of novel therapeutic strategies. Understanding the interconnectedness of the JAK2/STAT3/mTOR/PI3K pathway in tumorigenesis and the role of Astaxanthin (ASX), a red ketocarotenoid member of xanthophylls and potent antioxidant and anti-tumor activity, can be effective for cancer treatments.

A novel in-silico approach to design a multiepitope peptide as a vaccine candidate for .

Introduction: is a Gram-negative bacterium with a rod-shaped structure and a member of the genus. It is commonly found in aquatic environments such as freshwater, estuaries, and sewage. Known as an opportunistic pathogen, can infect both aquatic animals and humans.

Curcumin Aattenuates the Expression of Metalloprotease (AHA_0978) and Serine Protease (AHA_3857) Genes in Aeromonas Hydrophila.

Background: Aeromonas hydrophila is a pathogenic bacterium responsible for various infections in humans and animals. Bacterial exoproteases are considered an important determinant in the pathogenicity of A. hydrophila.

Apoptosis Effects of L. Extract on Human MCF-7 Breast Cancer Cell Line:

Recently, the non-toxic properties of natural plant products have gained more focus as anticancer agents. Therefore, this study aimed to assess the apoptosis effects of the ethanolic extract of on the MCF-7 breast cancer cell line. In this experimental study, aerial parts of were collected in Lahijan city (Iran), and after confirmation, they were dried and extracted with ethanol for 24 h.

Is latent tuberculosis infection challenging in Iranian health care workers? A systematic review and meta-analysis.

Background: The high chances of getting latent tuberculosis infection (LTBI) among health care workers (HCWs) will an enormous problem in low and upper-middle-income countries.

Method: Search strategies were done through both national and international databases include SID, Barakat knowledge network system, Irandoc, Magiran, Iranian national library, web of science, Scopus, PubMed/MEDLINE, OVID, EMBASE, the Cochrane library, and Google Scholar search engine. The Persian and the English languages were used as the filter in national and international databases, respectively.

Prevalence of group B streptococcus colonization in Iranian pregnant women: A systematic review and meta-analysis.

Background: Group B Streptococcus (GBS) is an important pathogen in newborns and pregnant women.

Objective: The present study was carried out to estimate the prevalence of GBS colonization in pregnant women in Iran.

Materials And Methods: This systematic review and meta-analysis was based on Preferred Reporting Items for Systematic Reviews and Meta-Analysis guideline using the national databases including Society for Information Display, Magiran, Irandoc, Iran Medex, and international databases including MEDLINE, Web of Science, Scopus, PubMed, Science-Direct, Cochrane, Embase, Elton Bryson Stephens Company, Centre for Evidence-Based Medicine, Cumulative Index to Nursing and Allied Health Literature, and Google Scholar, published by 01/30/2017.

Correction: Epidemiology of multiple sclerosis in Iran: A systematic review and meta-analysis.

[This corrects the article DOI: 10.1371/journal.pone.

Effect of Yoga on Lipid Profile and C-reactive Protein in Women.

Background: Few scientific studies have been conducted about the effect of yoga on biochemical variables such as total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and C-reactive protein (CRP) to lay a scientific foundation regarding benefits of yoga, but its effect is not clearly detected yet. This study was conducted to assess the effect of yoga on lipid profile and CRP in women.

Methods: This research was designed as an interventional study.

Epidemiology of multiple sclerosis in Iran: A systematic review and meta-analysis.

Background: Multiple sclerosis (MS) is one of the most common neurological disorders and is one of the main causes of disability. The prevalence and incidence of MS in Iran is reported to range from 5.3 to 89/ 100,000and 7 to 148.

Workplace Violence Against Iranian Nurses: A Systematic Review and Meta-Analysis.

Nurses are exposed to workplace violence more than other healthcare professionals. This study aims to examine the prevalence of different types of workplace violence against Iranian nurses. A systematic review and meta-analysis were designed according to the PRISMA statement.

Work-Related Musculoskeletal Disorders in Iranian Dentists: A Systematic Review and Meta-analysis.

Background: Work-related musculoskeletal disorders are the most important problems among professions particularly, dentists. This study was conducted to determine the prevalence of musculoskeletal disorders in various parts of the body in Iranian dentists by using systematic review and meta-analysis.

Methods: This systematic review and meta-analysis was based on preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines and searching in national databases such as SID, Magiran, Irandoc, IranMedex, and Medlib, and international databases such as MedLine, Web of Sciences, Scopus, PubMed, ScienceDirect, Cochrane, Embase, Springer, Wiley Online Library, Ebsco, CEBM, and Google Scholar search engine which were published by January 1, 2017.

Lung cancer in idiopathic pulmonary fibrosis: A systematic review and meta-analysis.

Background: There are many epidemiological pieces of evidence that show IPF patients have the highest risk of lung cancer. We conducted a systematic review of all published data to define the characteristics of lung cancer that develops in IPF by performing a meta-analysis.

Method: This study was performed based on the PRISMA guideline.

Prevalence of Chlamydia trachomatis in Pregnant Iranian Women: A Systematic Review and Meta-Analysis.

Several studies have been conducted regarding the prevalence of Chlamydia trachomatis, Mycoplasma hominis, and Ureaplasma urealyticum in pregnant Iranian women. However, it is necessary to combine the previous results to present a general assessment. We conducted the present study based on systematic review and meta-analysis studies according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).

The relation of maternal hypothyroidism and hypothyroxinemia during pregnancy on preterm birth: An updated systematic review and meta-analysis.

Background: The clinical consequences of hypothyroidism and hypothyroxinemia during pregnancy such as preterm birth are not still clear.

Objective: The aim of this meta-analysis was to estimate the relation of clinical and subclinical hypothyroidism and hypothyroxinemia during pregnancy and preterm birth.

Materials And Methods: In this meta-analysis, Preferred Reporting Items for Systematic review and Meta-Analysis were utilized.

Epidemiology of Toxoplasma gondii among blood donors in Iran: A systematic review and meta-analysis.

Introduction: Asymptomatic Toxoplasma gondii transmitted from blood donors to receiving patients has become a concern. Numerous articles have been published on the epidemiology of T. gondii in blood donors in Iran and a systematic review of the results shows quite different findings, hence this study was conducted to determine the seroprevalence of T.