Simulation of fractionated and continuous irradiation in photodynamic therapy: study the differences between photobleaching and singlet oxygen dose deposition.

This study aims to compare the continuous irradiation with fractionated irradiation for photodynamic therapy (PDT) of solid tumors with intraperitoneally administered 5-aminolaevulinic acid (ALA). Therefore, considering the complex physiology of solid tumors and in order to inform simulations well, we did experiments on Balb/c mice using non-invasive fluorescence spectroscopy to have a feedback of protoporphyrin IX (PpIX) concentration in tumor just before irradiation and during treatment. PDT simulations were performed based on delivery of 36 J cm(-2) total laser energy (630 nm) at the fluence rate of 40 mW cm(-2) either for continuous or fractionated illumination.

Towards skin polarization characterization using polarimetric technique.

Measurement of optical properties of skin is an expanding and growing field of research. Recent studies have shown that the biological tissue, especially skin, changes the polarization state of the incident light. Using this property will enable the study of abnormalities and diseases that alter not only the light intensity but also its polarization state.

A data-mining approach to biomarker identification from protein profiles using discrete stationary wavelet transform.

Objective: To develop a new bioinformatic tool based on a data-mining approach for extraction of the most informative proteins that could be used to find the potential biomarkers for the detection of cancer.

Methods: Two independent datasets from serum samples of 253 ovarian cancer and 167 breast cancer patients were used. The samples were examined by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS).