Publications by authors named "Mohammad Heidarvand"
Background: Inflammatory cell death, PANoptosis, has been suggested to orchestrate the lymphocyte decrement among coronavirus disease-2019 (COVID-19) patients. The main aim of this study was to examine the differences in the expression of key genes related to inflammatory cell death and their correlation with lymphopenia in the mild and severe types of COVID-19 patients.
Materials And Methods: Eighty-eight patients (36 to 60 years old) with mild ( = 44) and severe ( = 44) types of COVID-19 were enrolled.
Correlation of Expression of MMP-2, ACE2, and TMPRSS2 Genes with Lymphopenia for Mild and Severity of COVID-19.
Iran J Allergy Asthma Immunol
February 2023
Some risk causes may be associated with the severity of COVID-19. The central host-pathogen factors might affect infection are human receptor angiotensin-converting enzyme 2 (ACE2), trans-membrane protease serine 2 (TMPRSS2), and SARS-CoV-2 surface spike (S)-protein. The main purpose of this study was to determine the differences in the expression the metalloproteinases-2 (MMP-2), MMP-9, ACE2, and TMPRSS2 genes and their correlation with lymphopenia in the mild and severe types of the COVID-19 patients.
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- Systemic lupus erythematosus (SLE) is an autoimmune disease involving immune system abnormalities, and this study examines the impact of vitamin D3 on important cytokines in SLE patients.
- A group of 65 new-onset SLE patients were analyzed by treating their immune cells with vitamin D3 and measuring changes in cytokine gene expressions, particularly IL-2, IL-4, IL-5, IL-10, and IFN-γ.
- Results showed vitamin D3 led to a significant decrease in several cytokines and an increase in IL-2, suggesting that the timing of vitamin D3 administration may influence its effects and should be tailored to the specific phase of the disease in lupus patients.