Subchronic effects of different doses of Zinc oxide nanoparticle on reproductive organs of female rats: An experimental study.

Background: Zinc performs many biochemical and physiological functions; however, toxicological studies demonstrate that Nano-zinc oxide has harmful effects on human health and environmental species in high concentrations.

Objective: The aim of this study was to investigate the toxicity of zinc oxide nanoparticles on reproductive tissues of female rat.

Materials And Methods: Eighty female Wistar adult rats weighing 180-200 gr, divided into eight groups (n= 10 in each group) including control, sham (treated with saline), and six groups injected with different doses of zinc oxide nanoparticle with 10-30 nanometer size (4, 8, 25, 50, 100, and 200 mg/kg) twice a week for four weeks.