Publications by authors named "Mohammad Haris Ali"
Background: Nonalcoholic fatty liver disease (NAFLD) is increasingly concerning due to its rising prevalence. It encompasses conditions from simple steatosis to severe nonalcoholic steatohepatitis (NASH), posing risks such as fibrosis, cirrhosis, or hepatocellular carcinoma if untreated. This systematic review and meta-analysis aims to assess aldafermin, an FGF19 analog, for efficacy and safety in NASH patients.
View Article and Find Full Text PDFThere are no Food and Drug Administration (FDA)-approved treatment options for nonalcoholic steatohepatitis (NASH) which is a prevailing disease that leads to fibrosis, cirrhosis, or hepatocellular carcinoma. Hence, this systematic review and meta-analysis aims to determine the efficacy and safety of resmetirom, the first FDA-approved drug, for the treatment of NASH. A Grading of Recommendations, Assessment, Development, and Evaluation assessed systematic search of Cochrane Library, MEDLINE, Scopus, and Google Scholar database was conducted from inception till 31 March 2024.
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- - Crohn's disease (CD) is a chronic inflammatory bowel disorder with symptoms like abdominal pain and diarrhea, affecting 100-300 per 100,000 people, mainly in Western countries.
- - Recent clinical trials, like VIVID-1, found that the drug mirikizumab significantly outperformed placebo in treating CD, showing better clinical response and remission rates compared to ustekinumab and other treatments like risankizumab.
- - Mirikizumab's promising results suggest it could be a valuable addition to CD therapies, highlighting the need for further research on its long-term safety and effectiveness, as well as updated guidelines for better patient access.
Background: Diarrhea is a prevalent condition affecting millions worldwide. However, current standard diagnostic methods have many drawbacks. This review examines various non-invasive point-of-care (POC) tests and biomarkers aiding rapid diagnosis of diarrhea from different causes.
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- Several treatments for Demodex blepharitis exist, but they often have undesirable side effects; lotilaner is proposed as a safer alternative.
- A systematic review and meta-analysis, analyzing six relevant studies, determined lotilaner's effectiveness in eradicating Demodex mites.
- Results indicate that lotilaner is not only effective but also well-tolerated, suggesting it could be a promising treatment option for Demodex blepharitis, and consideration of cost-effectiveness is encouraged.