Corneal stem cells niche and homeostasis impacts in regenerative medicine; concise review.

The limbal stem cells niche (LSCN) is an optimal microenvironment that provides the limbal epithelial stem cells (LESCs) and strictly regulates their proliferation and differentiation. Disturbing the LSCN homeostasis can lead to limbal stem cell dysfunction (LSCD) and subsequent ocular surface aberrations, such as corneal stromal inflammation, persistent epithelial defects, corneal neovascularisation, lymphangiogenesis, corneal opacification, and conjunctivalization. As ocular surface disorders are considered the second main cause of blindness, it becomes crucial to explore different therapeutic strategies for restoring the functions of the LSCN.

Organic soil amendments using vermicomposts under inoculation of N-fixing bacteria for sustainable rice production.

Organic and biological fertilizers are considered as a very important source of plant nutrients. A field experiment was conducted during 2017-2018 in paddy soil to investigate the effect of vermicomposting of cattle manure mixture with and rice straw on soil microbial activity, nutrient uptake, and grain yield under inoculation of N-fixing bacteria. Experimental factors consisted of organic amendments at six levels (vermicomposts prepared from manure (VM); manure + rice straw (VRM); manure + mixture (VAM); manure + rice straw + mixture (VRAM); raw manure without vermicomposting (M), and a control) and N-fixing bacteria at three levels (, , and non-inoculation).

Suppression of Unwanted ZZ Interactions in a Hybrid Two-Qubit System.

Mitigating crosstalk errors, whether classical or quantum mechanical, is critically important for achieving high-fidelity entangling gates in multiqubit circuits. For weakly anharmonic superconducting qubits, unwanted ZZ interactions can be suppressed by combining qubits with opposite anharmonicity. We present experimental measurements and theoretical modeling of two-qubit gate error for gates based on the cross resonance interaction between a capacitively shunted flux qubit and a transmon, and demonstrate the elimination of the ZZ interaction.

Deep learning LI-RADS grading system based on contrast enhanced multiphase MRI for differentiation between LR-3 and LR-4/LR-5 liver tumors.

Background: To develop a deep learning (DL) method based on multiphase, contrast-enhanced (CE) magnetic resonance imaging (MRI) to distinguish Liver Imaging Reporting and Data System (LI-RADS) grade 3 (LR-3) liver tumors from combined higher-grades 4 and 5 (LR-4/LR-5) tumors for hepatocellular carcinoma (HCC) diagnosis.

Methods: A total of 89 untreated LI-RADS-graded liver tumors (35 LR-3, 14 LR-4, and 40 LR-5) were identified based on the radiology MRI interpretation reports. Multiphase 3D T1-weighted gradient echo imaging was acquired at six time points: pre-contrast, four phases immediately post-contrast, and one hepatobiliary phase after intravenous injection of gadoxetate disodium.

International Perspective on Revision Anterior Cruciate Ligament Reconstruction: What Have We Been Missing?

Primary anterior cruciate ligament (ACL) reconstruction is a common orthopaedic procedure. A graft failure rate of 5% to 10% after primary ACL reconstruction has resulted in an increased need for revision ACL reconstruction. ACL reconstruction failure etiologies include trauma, technical errors, and biologic factors.

Protective effect of L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats.

Objectives: Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury.

Materials And Methods: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract.

Clinical Outcome of Total Knee Arthroplasty After Prior Microfracture: A Matched Cohort Study.

Microfracture (MFX) is a common operation for articular cartilage lesions. Data for patients who underwent total knee arthroplasty (TKA) after previous MFX are limited. The purpose of this study was to determine the outcomes, complications, and factors that influence outcomes in patients with previous MFX compared with those without previous MFX.

Deregulation of miR-93 and miR-143 in human esophageal cancer.

Esophageal squamous cell carcinoma (ESCC) is the second and third most common malignancy in Iranian males and females, respectively. Treatment of ESCC is largely ineffective due to lack of detection at early stages of the disease. In recent years, miRNA, a small RNA molecule, has drawn much attention to researchers as a potential biomarker for esophageal cancer.

The protective effect of vitamin E against prenatal and early postnatal ethanol treatment-induced heart abnormality in rats: a 3-month follow-up study.

Ethanol consumption during pregnancy is associated with fetal heart malformation. However, the underlying mechanism of prenatal ethanol exposure causing heart malfunction is not well known. The current study examined the effect of prenatal and early postnatal ethanol consumption on heart abnormality resulting from oxidative and inflammatory stress.

PCR and Elisa methods (IgG and IgM): their comparison with conventional techniques for diagnosis of Mycobacterium tuberculosis.

In order to establish a rapid and stable method for diagnosis of Mycobacterium tuberculosis infection and minimize the side effects of delayed diagnosis on patients and health system, a cross sectional study was carried out. Since, the infection rate with this bacteria increasing and one of the reasons for this increase is long process of laboratory identification, therefore establishing new diagnosis methods could decrease disease rate. To achieve this aim, collected sputum and blood specimens from 50 patients with clinical suspicion of pulmonary tuberculosis were studied with both traditional, acid-fast stain (AFB) and culture method compare to Enzyme-linked immunosorbent assay (Elisa) (IgG and IgM) and Polymerase Chain Reaction (PCR) methods.

Salivary gland tumors in an Iranian population: a retrospective study of 130 cases.

Purpose: Tumors of the salivary glands are uncommon, comprising 3% to 10% of head and neck neoplasia. In the absence of epidemiologic studies of these neoplasms in an Iranian population, we conducted a preliminary survey of 130 cases over the last 20 years in Hamedan, Iran.

Patients And Methods: The medical records and case notes of all patients with histologically confirmed salivary gland tumors were reviewed retrospectively from February 1984 to March 2003.

Superficial lobe parotid gland lipoma.

The author presents a case of superficial lobe of the parotid gland lipoma. The lipoma is an asymptomatic, slow growing, freely movable and relatively rare soft mass. Preoperative diagnosis is generally difficult.

Blindness after facial fractures: a 19-year retrospective study.

Purpose: We conducted a 19-year review of patients with facial fractures who were treated in the Iranian Maxillofacial Unit at the Mobasher Emergency Hospital, Hamedan Province, Iran, to specifically consider those fractures that resulted in blindness or severe visual impairment.

Materials And Methods: During the period of February 16, 1984, to March 20, 2003, a total of 2,503 patients with facial fractures were operatively treated. Of these, 550 (22%) patients had orbital region fractures and were specifically studied.

Maxillofacial fractures in Hamedan province, Iran: a retrospective study (1987-2001).

Background: This study presents the various types, causes and incidence, along with their clinical management and associated complications of maxillofacial fractures at an emergency hospital in Hamedan, Iran.

Patients And Methods: A total of 2268 patients with 3107 facial fractures treated between 1987 and 2001, were retrospectively analysed. The average number of fractures for each patient was 1.