Publications by authors named "Mohammad Ghoreishifar"
Background: Genome sequence variants affecting complex traits (quantitative trait loci, QTL) are enriched in functional regions of the genome, such as those marked by certain histone modifications. These variants are believed to influence gene expression. However, due to the linkage disequilibrium among nearby variants, pinpointing the precise location of QTL is challenging.
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- Inbreeding depression, resulting from mating between closely related individuals, negatively impacts semen traits such as ejaculate volume, sperm concentration (SC), and sperm motility (SM) in Holstein bulls.
- A study analyzing ~330,000 semen records from ~1,500 bulls found that a 1% increase in inbreeding coefficients decreased SM by 0.28% and SC by 0.42%.
- Genome-wide association studies identified specific genetic regions on chromosomes 3, 8, 9, 21, and 28 linked to inbreeding depression, with several candidate genes associated with reproduction and male fertility.