Publications by authors named "Mohammad Ghaffari"

Article Synopsis
  • * It found that 56% of the identified CRISPR-Cas systems belong to subtypes I-E/I-C, 23% to III-A/III-D, and 17% to II-A, with specific plasmids targeted by distinct systems.
  • * The research concluded that strains with type-I CRISPR-Cas systems have a wider range of phage targets, highlighting the critical role of these systems in protecting against viral infections.
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Objectives: Peri-implantitis (PI) is the most common biological issue surrounding dental implants. According to current knowledge, the aforementioned complication is not equally distributed across different populations, and gene polymorphisms might be one contributing factor. The current study aimed to examine the association between gene polymorphisms of matrix metalloproteinase- (MMP-) 1, -2, -3, -7, and -13 with PI in an Iranian demographic.

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This study focuses on the genetic diversity and population structure of Prunus dulcis (almond tree), a crucial agricultural component with widespread cultivation and commercial importance, particularly in Iran, a region with a longstanding tradition of almond cultivation. The diverse almond collection in Iran encompasses many local varieties, breeding selections, rootstocks, and international cultivars. This diversity necessitates advanced genotyping techniques to gain insights into genetic diversity, population structure, and linkage disequilibrium (LD).

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The remobilization of stored assimilates from stems to seeds plays a pivotal role in augmenting barley yield, particularly under water stress conditions. This study examines the molecular mechanisms underlying stem reserve utilization by conducting a comparative analysis of the proteome and metabolome across three barley contrasting genotypes: Yousef, Morocco, and PBYT17. Evaluations were performed at 21 and 28 days after anthesis (DAA) under both water stress and control conditions.

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Background: A growing body of literature explores environmental risk factors for pediatric epistaxis, yielding variable results. We aim to clarify these associations through a systematic review and meta-analysis.

Methods: PubMed, Scopus, Cochrane Central Register of Control Trials, Web of Science, Medline, Google Scholars, and Embase were systematically searched up to April 2024.

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  • Early diagnosis of Diabetes insipidus (DI) after pituitary surgery is crucial to prevent severe complications, and measuring copeptin may provide a reliable prediction method.
  • A systematic review and meta-analysis was performed, assessing studies that measured copeptin levels in DI patients compared to non-DI patients, with a total of 1255 participants.
  • Results indicated that copeptin levels were significantly lower in DI patients and its early measurement showed moderate accuracy (0.791) in detecting post-op DI, highlighting its potential utility in clinical practice.
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Pichia kudriavzevii (formerly Candida krusei) poses a significant threat to immunocompromised patients due to its inherent resistance to various antifungal drugs. This study explored the anticandidal potential of citral, linalool, and carvacrol in combination with nystatin against P. kudriavzevii strains.

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The role of uric acid in pathogenesis of benign paroxysmal positional vertigo (BPPV) is not fully understood. It is aimed to assess the serum uric acid levels in BPPV patients compared to healthy controls. Systematic review and meta-analysis.

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  • This study investigates the differences in brain structure volumes among patients with relapsing-remitting multiple sclerosis (MS) compared to healthy individuals using MRI scans.
  • Results indicate that MS patients have lower volumes in the brainstem, cerebellum, thalamus, and globus pallidus, while the putamen and caudate nuclei are larger; disease and treatment duration are negatively correlated with thalamus and cerebellum volume.
  • The findings suggest that changes in the volumes of specific brain structures could serve as indicators of MS progression and associated disability.
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Background: There were controversial findings in terms of the association between the incidence of Benign Paroxysmal Positional Vertigo (BPPV) and climate changes, so the current systematic review plus meta-analysis is designed to discover this possible relationship.

Methods: Web of science, PubMed, Scopus, Google Scholar, Embase, and Cochrane library were systematically searched up to August 2023. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) and Problem/Population, Intervention, Comparison, and Outcome (PICO) guidelines were used.

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Cytokinin oxidase/dehydrogenase (CKX), responsible for irreversible cytokinin degradation, also controls plant growth and development and response to abiotic stress. While the gene has been studied in other plants extensively, its function in cotton is still unknown. Therefore, a genome-wide study to identify the gene family in the four cotton species was conducted using transcriptomics, quantitative real-time PCR (qRT-PCR) and bioinformatics.

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Background: The cuticular wax serves as a primary barrier that protects plants from environmental stresses. The Eceriferum (CER) gene family is associated with wax production and stress resistance.

Results: In a genome-wide identification study, a total of 52 members of the CER family were discovered in four Gossypium species: G.

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Potato is considered a key component of the global food system and plays a vital role in strengthening world food security. A major constraint to potato production worldwide is the Potato Virus Y (PVY), belonging to the genus Potyvirus in the family of Potyviridae. Selective breeding of potato with resistance to PVY pathogens remains the best method to limit the impact of viral infections.

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In our ongoing project, which focuses on the introgression of Booroola/FecB gene and the myostatin (MSTN) gene into purebred Moghani sheep, we assessed the performance of second-generation Moghani crossbreds such as second crossbreds (F2) and initial backcross generation (BC1). These crossbreds were generated through different mating systems, including in-breeding, outcrossing, first paternal backcrossing (PBC1), and first maternal backcrossing (MBC1). Notably, F2 strains exhibited lean tail, woolly fleece and a higher percentage of white coat color compared to BC1.

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Article Synopsis
  • Preserving genetic diversity is crucial for genetic improvement and adaptation, and this study analyzes seven Iranian horse breeds to pinpoint key genetic variants like SNPs, INDELs, and CNVs.
  • The research utilized whole-genome resequencing, generating a large amount of sequence data, with varying mapping rates to the horse reference genome, which revealed over 2.9 million SNPs, predominantly in intergenic regions.
  • The study highlighted Caspian horses as genetically distinct, showing fewer shared SNPs with Turkoman horses and a unique genetic profile that influences their sensory and reproductive traits, providing insights for their management and conservation.
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Cervical resorption is a serious threat to the longevity of the teeth. In this study, the Canny edge-detection algorithm was applied on CBCT images to compare the accuracy of original and Canny views for diagnosing cervical resorption in endodontically treated teeth. Intracanal metallic posts were inserted in 60 extracted teeth being randomly divided into three groups: control, 0.

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Given emerging food supply challenges for the world population, Genetic Modified Organisms (GMOs) are referred to as a solution to the upcoming food security crisis. Besides technological advancement, other significant components such as public Awareness play an important role in national and international scientific regulations. Towards this, this study evaluated Tehranian consumers' Awareness (a sample including 946 respondents) about GMOs' risks and benefits, trust in governmental regulation, and the ways to obtain information about GMOs.

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Article Synopsis
  • The study examines the link between specific matrix metalloproteinase (MMP) gene polymorphisms and chronic periodontitis (CP) in an Iranian population by comparing 87 CP patients with 89 healthy individuals.
  • Results show that variations in the MMP-1, MMP-3, and MMP-7 genes are significantly associated with CP risk, while MMP-2 and MMP-13 do not show a significant effect.
  • Findings suggest that certain gene variants could influence the likelihood of developing CP, highlighting the importance of considering these factors in clinical periodontal treatment strategies.
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Background: There is a dearth of comprehensive studies examining the burden and trends of hypertensive heart disease (HHD) and high systolic blood pressure (SBP) among the Australian population. We aimed to explore the burden of HHD and high SBP, and how they changed over time from 1990 to 2019 in Australia.

Methods: We analysed data from the Global Burden of Disease study in Australia.

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Background: A salutary effect of treatments for Gaucher disease (GD) has been a reduction in the incidence of avascular osteonecrosis (AVN). However, there are reports of AVN in patients receiving enzyme replacement therapy (ERT) , and it is not known whether it is related to individual treatments, genotypes, phenotypes, biomarkers of residual disease activity, or anti-drug antibodies. Prompted by development of AVN in several patients receiving ERT, we aimed to delineate the determinants of AVN in patients receiving ERT or eliglustat substrate reduction therapy (SRT) during 20 years in a tertiary referral center.

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Background: The mechanisms underlying rice root responses to drought during the early developmental stages are yet unknown.

Results: This study aimed to determine metabolic differences in IR64, a shallow-rooting, drought-susceptible genotype, and Azucena, a drought-tolerant and deep-rooting genotype under drought stress. The morphological evaluation revealed that Azucena might evade water stress by increasing the lateral root system growth, the root surface area, and length to access water.

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This study aimed to compare growth performance between Moghani sheep and crossbred lambs resulting from crossbreeding between Moghani pure breed ewes and the lines of rams e.g., Texel Tamlet, Texel Dalzell, Booroola Merino, and Booroola Romney.

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The hydrangea ( (Thunb). Ser.), an ornamental plant, has good marketing potential and is known for its capacity to change the colour of its inflorescence depending on the pH of the cultivation media.

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Implant fracture is a rare but devastating complication of treatment in partially or fully edentulous patients which requires prompt diagnosis. Nevertheless, studies on defining the most accurate technique for the detection of implant fractures are lacking. In the present study, the Canny edge detection algorithm was applied on multiple radiographic modalities including parallel periapical (PPA), oblique periapical (OPA), and cone beam CT (CBCT) with and without metal artifact reduction (MAR) to examine its accuracy for diagnosis of simulated implant fractures.

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Background: Plant organelles are highly motile where their movement is significant for fast distribution of material around the cell, facilitation of the plant's ability to respond to abiotic and biotic signals, and for appropriate growth. Abiotic and biotic stresses are among the major factors limiting crop yields, and biological membranes are the first target of these stresses. Plants utilize adaptive mechanisms namely myosin to repair injured membranes following exposure to abiotic and biotic stresses.

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