Hypertension: Constraining the Expression of ACE-II by Adopting Optimal Macronutrients Diet Predicted via Support Vector Machine.

The recent elevation of cases infected from novel COVID-19 has placed the human life in trepidation mode, especially for those suffering from comorbidities. Most of the studies in the last few months have undeniably raised concerns for hypertensive patients that face greater risk of fatality from COVID-19. Furthermore, one of the recent WHO reports has estimated a total of 1.

Inbuilt Tendency of the eIF2 Regulatory System to Counteract Uncertainties.

Eukaryotic initiation factor 2 (eIF2) plays a fundamental role in the regulation of protein synthesis. Investigations have revealed that the regulation of eIF2 is robust against intrinsic uncertainties and is able to efficiently counteract them. The robustness properties of the eIF2 pathway against intrinsic disturbances is also well known.

Modeling and Dynamic Behavior of eIF2 Dependent Regulatory System With Disturbances.

Eukaryotic initiation factor 2 (eIF2) is a central controller of the eukaryotic translational machinery. To sustain the on-going translation activity, eIF2 cycles between its GTP and GDP bound states. However, in response to cellular stresses, the phosphorylation of eIF2 takes place, which acts as an inhibitor of the guanine nucleotide exchange factor eIF2B and switches the translation activity on physiological timescales.

Origins of robustness in translational control via eukaryotic translation initiation factor (eIF) 2.

Phosphorylation of eukaryotic translation initiation factor 2 (eIF2) is one of the best studied and most widely used means for regulating protein synthesis activity in eukaryotic cells. This pathway regulates protein synthesis in response to stresses, viral infections, and nutrient depletion, among others. We present analyses of an ordinary differential equation-based model of this pathway, which aim to identify its principal robustness-conferring features.