Publications by authors named "Mohammad El-Mouzan"
Background: Although the role of fungi in gut inflammation in IBD has been suggested, data are still limited in ulcerative colitis (UC). Our aim was to describe the gut fungal profile in a pediatric UC in Saudi Arabia.
Methods: Fecal samples from children with UC and control samples provided by healthy school children were collected.
Background: The role of microbiota in the pathogenesis of ulcerative colitis (UC) has been increasingly recognized. However, most of the reports are from Western populations. In Middle Eastern countries, including Saudi Arabia, little is known about the role of microbiota.
View Article and Find Full Text PDFBackground: Functional constipation (FC) is a common condition in children, and information on the clinical characteristics of FC in Saudi children is scarce.
Objective: Describe the clinical profile of FC in Saudi children.
Design: Retrospective.
Gut microbiota predicts the diagnosis of ulcerative colitis in Saudi children.
World J Clin Pediatr
March 2024
Background: Ulcerative colitis (UC) is an immune-mediated chronic inflammatory condition with a worldwide distribution. Although the etiology of this disease is still unknown, the understanding of the role of the microbiota is becoming increasingly strong.
Aim: To investigate the predictive power of the gut microbiota for the diagnosis of UC in a cohort of newly diagnosed treatment-naïve Saudi children with UC.
Multichannel intraesophageal impedance with pH metry in Saudi children.
Saudi J Gastroenterol
March 2024
Background: Multichannel Intraesophageal Impedance with pH (MII-pH) provides complete characterization of gastroesophageal reflux (GER). The aim of this study was to report our experience in this relatively new technique, emphasizing the challenges in the performance and interpretation of the results.
Methods: The study was conducted at King Khalid University Hospital at King Saud University in Riyadh.
Background And Study Aim: Fungi have a well-established role in medicine. Herein, we describe the fungal profile and abundance in the gut of healthy Saudi children.
Patients And Methods: Fecal samples from a random sample of 20 school-age Saudi children were collected, stored at -80 °C, and dispatched to the laboratory in the USA where fungal DNAs were isolated and shotgun metagenomic sequencing was performed.
Article Synopsis
- This report investigates the types and amounts of viruses present in the guts of healthy Saudi children to better understand their health impact.
- The study involved analyzing stool samples from 20 children in Riyadh, identifying that the Caudovirales order was the most abundant, particularly the Enterobacteria phages.
- Results indicate significant differences in the gut virome of these children compared to existing literature, highlighting the need for further research with larger populations to explore the implications for health and disease treatment.
Background: Celiac serology can be transiently elevated in patients with type 1 diabetes mellitus (T1DM) and normalized despite gluten consumption. This study aimed to identify the frequency and predictive factors of spontaneous normalization of anti-tissue transglutaminase (anti-TTG-IgA) antibodies in these patients.
Methods: The charts of all patients (≤18 years) with T1DM were retrospectively reviewed from 2012 to 2021 at a tertiary care center in Riyadh, Saudi Arabia.
Gut microbiota predicts the diagnosis of celiac disease in Saudi children.
World J Gastroenterol
April 2023
Background: Celiac disease (CeD) is a multisystem immune-mediated multifactorial condition strongly associated with the intestinal microbiota.
Aim: To evaluate the predictive power of the gut microbiota in the diagnosis of CeD and to search for important taxa that may help to distinguish CeD patients from controls.
Methods: Microbial DNA from bacteria, viruses, and fungi, was isolated from mucosal and fecal samples of 40 children with CeD and 39 controls.
Background: Intestinal dysbiosis has been reported to be associated with celiac disease (CeD) in Western populations but little is known in other populations who have different dietary lifestyle and genetic background. The purpose of this study was to determine whether a different microbiota profile is associated with CeD in children in Saudi Arabia.
Results: Forty children with CeD, 20 healthy controls, and 19 non-CeD controls were enrolled.
Article Synopsis
- This study aimed to analyze the intestinal microbiota in healthy Saudi children to enhance understanding of its role in health and disease.
- Researchers collected and analyzed stool samples from 20 Saudi school children, identifying the most prevalent bacterial phyla and genera, with Firmicutes, Bacteroidetes, and Actinobacteria being the most abundant.
- The findings highlight that the microbiome composition in healthy Saudi children differs from other populations, prompting the need for further research to explore these variations and their implications for health.
Article Synopsis
- * This study analyzed the viral profiles from fecal and mucosal samples of 40 children with new-onset CeD and 39 healthy controls, finding distinct viral dysbiosis in the CeD group.
- * Although specific viral species were found to be more or less abundant in the fecal samples of children with CeD, mucosal samples did not show significant associations, highlighting the complexity of viral interactions in gut health and the need for more research.
Background: Although intestinal fungi are known to interact with the immune system, the relationship between intestinal fungi and childhood celiac disease (CeD), an immune-mediated condition, has rarely been reported.
Aims: The aim of this study was to describe gut fungal profiles in a cohort of children with new-onset CeD.
Methods: Mucosal and fecal samples were collected from children with CeD and controls and subjected to metagenomics analysis of fungal microbiota communities.
Background: Studies have reached different conclusions regarding the accuracy of dysbiosis in predicting the diagnosis of Crohn's disease (CD). The aim of this report is to assess the utility of mucosal and fecal microbial dysbiosis as predictors in the diagnosis of this condition in Saudi children.
Methods: Tissue and fecal samples were collected prospectively from children with final diagnosis of CD and from controls.
Background And Study Aim: The prevalence of nutritional disorders in Saudi children with inflammatory bowel diseases (IBDs) has been reported using the World Health Organization (WHO) reference. Our aim was to provide more accurate definition of the prevalence of nutritional impairment in Saudi children with IBDs based on the national growth reference and to demonstrate the effect of using a reference from other populations on the prevalence rates.
Patients And Methods: Weight, height, and body mass index data, from the multicenter study of IBDs in Saudi children and adolescents, were plotted on the new Saudi national growth reference.
Background: Incidence and severity variations of inflammatory bowel disease (IBD) have been reported from Western populations between continents and regions of the same countries. However, no data were available from other countries.
Aim: To investigate the regional differences in the IBD profiles of pediatric patients from the Kingdom of Saudi Arabia.
Background/aim: Delay in the diagnosis of inflammatory bowel disease (IBD) is associated with complications. Our aim was to describe the pattern and risk factors associated with delay in the diagnosis of IBD in Saudi children.
Patients And Methods: This was a multicenter study with a retrospective/prospective design.
Background: The role of microbiota in Crohn's disease (CD) is increasingly recognized. However, most of the reports are from Western populations. Considering the possible variation from other populations, the aim of this study was to describe the microbiota profile in children with CD in Saudi Arabia, a non-Western developing country population.
View Article and Find Full Text PDFFungal dysbiosis predicts the diagnosis of pediatric Crohn's disease.
World J Gastroenterol
October 2018
Article Synopsis
- The study aimed to assess the effectiveness of fungal dysbiosis in mucosal and stool samples for predicting Crohn's disease (CD) in children.
- Conducted in Saudi Arabia, the research involved 15 children with CD and 20 controls, analyzing their samples to determine fungal abundance and diversity using advanced sequencing methods.
- Results showed that the prediction accuracy was notably higher for stool samples (mean AUC = 0.85) compared to mucosal samples (mean AUC = 0.71), indicating that stool analysis may be more reliable for diagnosing CD in children.
Background/aim: Inflammatory bowel disease (IBD) is increasing in Saudi Arabia but there's little knowledge about its risk factors. Our aim is to investigate the dietary risk factors of this disease in Saudi children.
Patients And Methods: The children investigated for IBD were prospectively enrolled.
Ileocolonic Basidiobolomycosis in a Child: An Unusual Fungal Infection.
J Coll Physicians Surg Pak
August 2017
Systemic basidiobolomycosis is a rare fungal infection caused by Basidiobolus rararum (B. rararum). The clinical presentation is non-specific and is similar to many gastrointestinal conditions such as Crohn's disease (CD).
View Article and Find Full Text PDFBackground: Assessment of growth using Z-score methods is important for clinical care and research, yet growth reference Z-score data for preschool Saudi children are not available.
Objective: Establish Z-score tables and corresponding growth charts.
Design: Uses data from a national survey in 2004-2005.
Article Synopsis
- The study investigates the characteristics of fungal microbiota in children newly diagnosed with Crohn's disease (CD) compared to non-IBD controls, emphasizing a need for more research in this area.
- It was found that certain fungi, like Psathyrellaceae and Gymnopilus, were significantly more abundant in children with CD, while others, like Monilinia, were depleted.
- Despite observing significant differences in specific fungal taxa, no overall difference in fungal diversity between the CD patients and controls was noted, indicating a complex relationship that warrants further investigation.
Socioeconomic Impacts of Gluten-Free Diet among Saudi Children with Celiac Disease.
Pediatr Gastroenterol Hepatol Nutr
September 2016
Purpose: To determine the socio-economic impact of gluten free diet (GFD) on Saudi children and their families.
Methods: A cross-sectional study was conducted in which an online questionnaire was sent to all families registered in the Saudi celiac patients support group. We included only children (age 18 years of age and younger) with biopsy-confirmed celiac disease (CD).