The effect of clofibrate with phototherapy in late pre-term newborns with non-hemolytic jaundice.

Background: Despite an understanding of the enzymatic pathways leading to bilirubin production and degradation, very few pharmacologic interventions are utilized and the mainstay of treatment remains phototherapy.

Aims: To evaluate the efficacy of clofibrate in reducing total serum bilirubin levels in late pre-term neonates with non-hemolytic jaundice.

Design And Setting: Double-blind, placebo-controlled, randomized trial; tertiary level neonatal unit.