Publications by authors named "Mohammad Dastbaz"
Article Synopsis
- - The study explores the levels of interleukin-6 (IL-6) and interleukin-10 (IL-10), along with the expression of various genes associated with immune regulation, in newly diagnosed rheumatoid arthritis (RA) patients before and after treatment with DMARDs compared to healthy individuals.
- - Results indicated that RA patients had significantly higher IL-6 levels and lower IL-10 levels before treatment, but IL-6 decreased and IL-10 increased post-treatment with DMARDs, showing an improvement in their inflammatory profiles.
- - Gene expression analysis showed that certain regulatory genes (FoxP3, Sema-3A, Nrp-1) were upregulated after treatment, indicating a beneficial effect
Objectives: The dysregulated immune response is one of the cardinal features of severe coronavirus disease 2019 (COVID-19). This study was conducted to clarify the occurrence of autoantibodies (AABs) associated with systemic autoimmune rheumatic diseases (SARDs) in hospitalized patients with a moderate, severe, and critical form of COVID-19.
Methods: The serum samples obtained from 176 hospitalized COVID-19 patients were investigated in this study, including patients with moderate (N = 90), severe (N = 50), and critical (N = 36) forms of COVID-19.
Background: Metabolic dysregulation and excessive inflammation are implicated in the pathogenesis of the highly infectious disease of coronavirus disease 2019 (COVID-19), which is caused by a newly emerging coronavirus (i.e., severe acute respiratory syndrome-coronavirus 2; SARS-CoV-2).
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