Publications by authors named "Mohammad Danish Uddin"
Article Synopsis
- Traumatic brain injury (TBI) leads to significant brain damage and can cause lasting cognitive issues, with effective treatments still difficult to find.
- The RhoA-ROCK signaling pathway, activated by TBI, is important as it can negatively impact dendritic spines crucial for memory and information processing.
- Blocking RhoA-ROCK signaling through methods like gene deletion or using the drug fasudil shows potential to improve motor and cognitive function after TBI, suggesting it may offer a new treatment avenue.
The small GTPases RhoA and Rac1 are key cytoskeletal regulators that function in a mutually antagonistic manner to control the migration and morphogenesis of a broad range of cell types. However, their role in shaping the cerebellum, a unique brain structure composed of an elaborate set of folia separated by fissures of different lengths, remains largely unexplored. Here we show that dysregulation of both RhoA and Rac1 signaling results in abnormal cerebellar ontogenesis.
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