Publications by authors named "Mohammad B Ghayour"
Osteopontin (OPN) is a multifunctional matrix glycoprotein with neuroprotective and immunomodulatory properties. This study explored the potential of OPN-loaded acellular nerve allografts (ANAs) to repair sciatic nerves in male Wistar rats. The research also delved into the impact of OPN on macrophage phenotypes.
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- EpoB is found to stabilize microtubules and has neuroprotective effects, making it a potential treatment for nerve injuries.
- The study investigates the effects of acellular nerve allografts (ANAs) supplemented with varying concentrations of EpoB on nerve regeneration in male Wistar rats with sciatic nerve deficits.
- Results show that ANAs with 0.1 nM EpoB significantly improved recovery metrics and nerve regeneration compared to higher concentrations, suggesting that lower doses of EpoB are more effective for nerve repair.
Article Synopsis
- Peripheral nerves have a natural ability to regenerate, but recovery after severe injuries is often insufficient, leading to incomplete sensorimotor recovery, making it crucial to explore alternative treatments.
- Researchers examined the effects of IL-33, a chemokine with neuroprotective properties, on nerve repair in male C57BL/6 mice following sciatic nerve injury.
- Results showed that higher doses of IL-33 (25 and 50 µg/kg) significantly improved nerve regeneration and sensorimotor recovery by promoting macrophage polarization toward a pro-healing M2 phenotype, reducing inflammation, and enhancing the expression of neurotrophic factors.
Objectives: Celastrol is an herbal compound with neuroprotective properties. Our research aimed to assess the neuroprotective properties of celastrol on sciatic nerve transection in rats.
Materials And Methods: The rats' left sciatic nerve was cut and sutured directly.
Following severe peripheral nerve injury (PNI), regeneration is often insufficient and functional recovery is incomplete. Any agents that limit the spread of neural tissue damage may enhance the nerve regeneration. In this regard, statins have been shown to have neuroprotective properties.
View Article and Find Full Text PDFCiticoline (cytidine-5'-diphosphocholine) is a neuroprotective agent that is administered following ischemic and traumatic brain injuries. There is little information about the antiseizure and anxiolytic effects of citicoline, which are therefore addressed in the present study. For evaluating the anticonvulsant effect of citicoline in the pentylentetrazole seizure model, a single intraperitoneal dose of citicoline was administered at 50, 100 or 150mg/kg.
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