Publications by authors named "Mohammad Atiqur Rahman"

High Mobility Group Box 1 (HMGB1) is a highly conserved non-histone chromatin-associated protein across species, primarily recognized for its regulatory impact on vital cellular processes, like autophagy, cell survival, and apoptosis. HMGB1 exhibits dual functionality based on its localization: both as a non-histone protein in the nucleus and as an inducer of inflammatory cytokines upon extracellular release. Pathophysiological insights reveal that HMGB1 plays a significant role in the onset and progression of a vast array of diseases, viz.

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Designing a cheap, competent, and durable catalyst for the oxygen evolution reaction (OER) is exceedingly necessary for generating oxygen through a water-splitting reaction. In this project, we have designed a ZIF-67-originated molybdenum-doped cobalt phosphide (CoP) using a simplistic dissolution-regrowth method using NaMoO and a subsequent phosphidation process. This leads to the formation of an exceptional hollow nanocage morphology that is useful for enhanced catalytic activity.

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The quest for sustainable and clean energy sources has intensified research on the Hydrogen Evolution Reaction (HER) in recent decades. In this study, we have presented a novel Ce-doped TiO catalyst synthesized through the sol-gel method, showcasing its potential as a superior electrocatalyst for HER in an acidic medium. Comprehensive characterization through X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Energy dispersive X-ray (EDX), and Raman spectroscopy confirms the successful formation of the catalyst.

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Article Synopsis
  • The study aimed to determine if heightened levels of cardiac troponin I (cTnI) could indicate poor functional outcomes in patients with ischemic stroke.
  • Conducted with 100 patients, those with elevated cTnI showed more severe stroke symptoms and a higher risk of mortality and unfavorable outcomes within 90 days.
  • The findings suggest that elevated cTnI is a significant independent predictor of worse short-term outcomes and lower survival rates after an ischemic stroke.
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  • The study aimed to compare the effectiveness and safety of analog insulins versus human insulins for controlling high blood sugar in hospitalized patients with acute strokes.
  • In a trial with 102 patients, there were no significant differences in average blood glucose levels or hypoglycemic events between the two insulin types, but severe hypoglycemia primarily occurred in those using human insulin.
  • The results suggested that while both types of insulin had similar outcomes, analog insulins may lead to slightly lower insulin requirements and a lower risk of severe hypoglycemia in patients with acute stroke and hyperglycemia.
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Herein, we report an efficient proton exchange membrane formed from a synergistic combination of graphene oxide (GO) and oxidized single-walled carbon nanotube (CNTOX) by the freeze-drying route that gives rise to enhanced fuel cell power density. At 25 °C and 100% relative humidity (RH), the 3DGO-CNTOX hybrid shows remarkably high out-of-plane and in-plane proton conductivities of 6.64×10 and 5.

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The viability of biorefining technology primarily depends on the facile cellulose conversion route with adequate conversion efficiency. Here we have demonstrated the microwave-assisted hydrolysis of cellulose to glucose using polyoxometalate (POM) clusters as acid catalysts. Two different types of POM, including Wells-Dawson and Keggin were justified as catalysts in the cellulose conversion process.

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The key challenges for converting chitin to 5-hydroxymethylfurfural (5-HMF) include the low 5-HMF yield. Moreover, the disadvantages of traditional acid-base catalysts including complex post-treatment processes, the production of by-products, and severe equipment corrosion also largely limit the large-scale conversion of chitin to 5-HMF. In this view, herein we have demonstrated a microwave aided efficient and green conversion of chitin to 5-HMF while using polyoxometalate (POM) as a catalyst and DMSO/water as solvent.

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Cuprous oxide (CuO) nanorods have been deposited on soda-lime glass substrates by the modified successive ionic layer adsorption and reaction technique by varying the concentration of NaCl electrolyte into the precursor complex solution. The structural, electrical and optical properties of synthesized CuO nanorod films have been studied by a variety of characterization tools. Structural analyses by X-ray diffraction confirmed the polycrystalline CuO phase with (111) preferential growth.

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The development of efficient proton conductors that are capable of high power density, sufficient mechanical strength, and reduced gas permeability is challenging. Herein, we report the development of a series of aromatic sulfonic acid/graphene oxide hybrid membranes incorporating benzene sulfonic acid (BS), naphthalene sulfonic acid (NS), naphthalene disulfonic acid (DS) or pyrene sulfonic acid (PS) using a facile freeze dried method. For out-of-plane proton conductivity, the 3DGO-BS and 3DGO-NS yielded proton conductivities of 4.

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Herein, we report the encapsulation and release of antimalarial drug quinine (QN) using three nanocarriers, including MCM-41 (1), and its 3-aminopropyl silane (aMCM-41 (2)) and 3-phenylpropyl silane (pMCM-41 (3)) surface functionalized derivatives. The pH and thermal optimization effects on QN adsorption and release from 1, 2 and 3 were investigated.

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Objective: Hyperglycemia may cause acute central nervous system dysfunction manifesting as agonizing involuntary movements due to insult to the basal ganglia. We report a case of hemichorea-hemiballism (HCHB) in a patient with diabetes.

Method: Clinical assessment of the patient was performed, along with laboratory tests and brain imaging.

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Protein Kinase CK2 (Casein Kinase 2 or CK2) is a constitutively active serine-threonine kinase overactive in human malignancies. Increased expression and activity of CK2 in Acute Myeloid Leukemia (AML) is associated with a poor outcome. CK2 promotes AML cell survival by impinging on multiple oncogenic signaling pathways.

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Here, we report the effect of the substrate, sonication process, and postannealing on the structural, morphological, and optical properties of ZnO thin films grown in the presence of isopropyl alcohol (IPA) at temperature 30-65 °C by the successive ionic layer adsorption and reaction (SILAR) method on both soda lime glass (SLG) and Cu foil. The X-ray diffraction (XRD) patterns confirmed the preferential growth thin films along (002) and (101) planes of the wurtzite ZnO structure when deposited on SLG and Cu foil substrates, respectively. Both XRD and Raman spectra confirmed the ZnO and Cu-oxide phases of the deposited films.

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It has been more than 10 months since the first COVID-19 case was reported in Wuhan, China, still menacing the world with a possible second wave. This study aimed to analyze how meteorological variables can affect the spread of local COVID-19 transmission in Bangladesh. Nine spatial units were considered from a meteorological standpoint to characterize COVID-19 transmission in Bangladesh.

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IKAROS, encoded by the gene, is a DNA-binding protein that functions as a tumor suppressor in T cell acute lymphoblastic leukemia (T-ALL). Recent studies have identified IKAROS's novel function in the epigenetic regulation of gene expression in T-ALL and uncovered many genes that are likely to be directly regulated by IKAROS. Here, we report the transcriptional regulation of two genes, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta () and phosphoinositide kinase, FYVE-type zinc finger containing (), by IKAROS in T-ALL.

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Article Synopsis
  • - IBNtxA is a new μ-opioid receptor agonist derived from naltrexone, showing promise for pain relief (anti-nociception) without significant side effects or addiction potential.
  • - In studies, a 3 mg/kg dose of IBNtxA was found to be as effective as 10 mg/kg of morphine in pain relief tests, while also reducing morphine's side effects such as hyperactivity and withdrawal symptoms.
  • - IBNtxA exhibited complex interactions with various opioid receptors, suggesting it has a unique mechanism of action that could make it a valuable candidate for future pain management medications.
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Adequacy of iodine nutrition status in breastfeeding mothers is vital in preventing iodine deficiency disorder (IDD) in neonates and children. The aim of the study was to assess urinary iodine status in breastfeeding mothers attending Bangabandhu Sheikh Mujib Medical University (BSMMU) hospital in Bangladesh. In this cross-sectional study carried out from January 2014 to January 2015, urinary iodine (UI; gm/L) level of 266 mothers (age 26.

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Thymidine phosphorylase (TP) is often induced in the tumour microenvironment by physiological and chemical stress. Its induction protects cells from apoptosis and helps cell survival by stimulating nucleoside metabolism and angiogenesis. Chemotherapy often upregulates TP, which acts in cell rescue; this result indicates that TP is a crucial therapeutic target.

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Cyclooxygenase-2 (COX-2) inhibitors are regarded as potentially important in strategies for cancer treatment. however, the precise mechanisms of these anti-inflammatory drugs as anti-cancer therapy are still unknown. In this study, we examined the effect of DFU both in vitro on MCF-7 cell growth, as well as in vivo on tumor growth produced by MCF-7 cell injection in mice.

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Breast cancer is a worldwide epidemic among women, and one of the most rapidly increasing cancers. Not only the incidence rate but also the death rate is increasing. Despite enthusiastic efforts in early diagnosis, aggressive surgical treatment and application of additional non-operative modalities, its prognosis is still dismal.

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PTEN, a novel tumor suppressor, functions as a regulator of both cell cycle progression and apoptosis. PTEN gene is frequently mutated or deleted in several malignancies including human hepatocellular carcinoma (HCC). The clinical significance and prognostic value of PTEN expression in HCC or in the surrounding non-cancerous parenchyma remain obscure.

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