The safety and efficacy of bevacizumab in treatment of recurrent low-grade glioma: a systematic review and meta-analysis.

Background: Central nervous system (CNS) tumors are among the most common malignancies in various age ranges. Low-grade glioma (LGG) can account for nearly 30% of pediatric CNS malignancies. Progression or recurrence after the first-line treatments is common among these patients.

Prediction of the treatment response and local failure of patients with brain metastasis treated with stereotactic radiosurgery using machine learning: A systematic review and meta-analysis.

Background: Stereotactic radiosurgery (SRS) effectively treats brain metastases. It can provide local control, symptom relief, and improved survival rates, but it poses challenges in selecting optimal candidates, determining dose and fractionation, monitoring for toxicity, and integrating with other modalities. Practical tools to predict patient outcomes are also needed.

2,4-D adsorption from agricultural subsurface drainage by canola stalk-derived activated carbon: insight into the adsorption kinetics models under batch and column conditions.

In this study, the experimental and kinetic modeling investigations were performed to evaluate the ability of mesoporous and microporous canola stalk-derived activated carbon (CSAC) on 2,4-dichlorophenoxyacetic acid (2,4-D) removal from synthetic and natural water in both batch and continuous systems. Three empirical models (pseudo-first-order equation (PFOE), pseudo-second-order equation (PSOE), and the Elovich equation (EE)) and three theoretical models (film diffusion model (FDM), particle diffusion model (PDM), and second-order chemical reaction rate model (SOCRRM)) were compared in terms of diffusion coefficients, maximum 2,4-D adsorption, and rate constants at various operating conditions. CSAC was prepared at 600 °C and activated with water steam under a controlled flow and subsequently characterized by various analytical methods.

A Spiderweb-Like Metal-Organic Framework Multifunctional Foam.

Processing metal-organic frameworks (MOFs) into hierarchical macroscopic materials can greatly extend their practical applications. However, current strategies suffer from severe aggregation of MOFs and limited tuning of the hierarchical porous network. Now, a strategy is presented that can simultaneously tune the MOF loading, composition, spatial distribution, and confinement within various bio-originated macroscopic supports, as well as control the accessibility, robustness, and formability of the support itself.

Covalent polybenzimidazole-based triazine frameworks: A robust carrier for non-steroidal anti-inflammatory drugs.

Covalent triazine-based polymers (CTPs) are a new class of porous materials that can be used for the intercalation of therapeutic agents. The main purposes of designing new drug carriers include protecting them from degradation, enhancing their poor aqueous solubility, and investigating their controlled release properties. In this context, a novel polybenzimidazole-based CTP (BZ-CTP) was prepared by a solvothermal reaction between 4,4',4″-((1,3,5-triazine-2,4,6-triyl) tris(azanediyl)) tribenzoic acid (TCA) and 3,3'-diaminobenzidine.

A Robust Aqueous Core-Shell-Shell Coconut-like Nanostructure for Stimuli-Responsive Delivery of Hydrophilic Cargo.

Conventional delivery systems for hydrophilic material still face critical challenges toward practical applications, including poor retention abilities, lack of stimulus responsiveness, and low bioavailability. Here, we propose a robust encapsulation strategy for hydrophilic cargo to produce a wide class of aqueous core-shell-shell coconut-like nanostructures featuring excellent stability and multifunctionality. The numerous active groups (-SH, -NH, and -COOH) of the protein-polysaccharide wall material enable the formation of shell-cross-linked nanocapsules enclosing a liquid water droplet during acoustic cavitation.

Selective Electrochemical Capture and Release of Heparin Based on Amine-Functionalized Carbon/Titanium Dioxide Nanotube Arrays.

Heparin (HEP) is a sulfated glycosaminoglycan that is a clinical anticoagulant agent. Commercially derived from porcine intestinal mucosa, HEP is challenging to separate from this complex biological mixture for additional purification. This study aimed to raise the purity of isolated HEP using electrochemical potential to increase its selective capture and release.

A simple route to renewable high internal phase emulsions (HIPEs) strengthened by successive cross-linking and electrostatics of polysaccharides.

We demonstrate a simple synthesis of renewable high internal phase emulsions (HIPEs) featuring great stability and processability, by centrifuging ultrasonication-produced oil-filled polysaccharide microspheres without the aid of any surfactant or synthetic particles. The properties of HIPEs and corresponding porous structure (closed-/open-cell) are controllable by simply adjusting the ultrasonic intensity and ionization of polysaccharides.

The Effect of Recorded Mum's Lullaby and Brahm's Lullaby on Oxygen Saturation in Preterm Infants: a Randomized Double-Blind Clinical Trial.

Introduction: Music stimulation has been shown to provide significant benefits to preterm infants. Thus the aim of this study was determine the effect of recorded mum's lullaby and Brahm's lullaby on oxygen saturation in preterm infants.

Methods: This double-blind randomized controlled trial was carried out on 66 premature newborns with the postnatal age of ≥3 days and weight ≤ 2800 grams at Taleghani Hospital.