Analgesic effects of intraarticular anaesthetic lidocaine and methylprednisolone versus methylprednisolone alone following knee arthroscopy.

Background: Knee arthroscopy is a widely practiced orthopaedic procedure known for its minimally invasive approach, allowing quicker recovery times and less postoperative discomfort than traditional open surgeries. However, managing postoperative pain remains a critical aspect of patient care and satisfaction. The main objective of this research is to examine the relationships between patient demographics (age, gender, BMI) and early postoperative outcomes, including pain, physiotherapy, and walking.

Antimicrobial Resistance and Public Health Risks Associated with Staphylococci Isolated from Raw and Processed Meat Products.

This study aimed at evaluating the occurrence, antibiotic resistance, and β-lactamase production in isolates recovered from meat and meat products, as well as the incidence of antimicrobial resistance (AMR) genes in these bacterial isolates. The prevalence of was very high (75% and 50%) in street kebab and raw buffalo meat, respectively. The antibiotic resistance and susceptibility behavior showed that 82% of the isolates were resistant to β-lactam antibiotics such as aztreonam, followed by methicillin (68%), oxacillin (54%), cefepime (36%), ceftazidime (34%), cefaclor (24%), cefotaxime (22%), ertapenem (4%), meropenem and imipenem (2%).

BEATS: BEAmline for synchrotron X-ray microTomography at SESAME.

The ID10 beamline of the SESAME (Synchrotron-light for Experimental Science and Applications in the Middle East) synchrotron light source in Jordan was inaugurated in June 2023 and is now open to scientific users. The beamline, which was designed and installed within the European Horizon 2020 project BEAmline for Tomography at SESAME (BEATS), provides full-field X-ray radiography and microtomography imaging with monochromatic or polychromatic X-rays up to photon energies of 100 keV. The photon source generated by a 2.

Cannabis use by individuals with spinal cord injury in the UK: a call for improved patient education and physician awareness for pain and spasticity management.

Study Design: Prospective observational qualitative study.

Objective: Cannabis is used by patients for the treatment of chronic pain, spasticity, sleep issues or mood disorders such as anxiety and depression. Since 2018, it has been authorised in the United Kingdom for medical use as an unlicensed medicine.

Critical Prandtl Number for Heat Transfer Enhancement in Rotating Convection.

Rotation, which stabilizes flow, can enhance the heat transfer in Rayleigh-Bénard convection (RBC) through Ekman pumping. In this Letter, we present the results of our direct numerical simulations of rotating RBC, providing a comprehensive analysis of this heat transfer enhancement relative to nonrotating RBC in the parameter space of Rayleigh number (Ra), Prandtl number (Pr), and Taylor number (Ta). We show that for a given Ra, there exists a critical Prandtl number (Pr_{cr}) below which no significant heat transfer enhancement occurs at any rotation rate, and an optimal Prandtl number (Pr_{opt}) at which maximum heat transfer enhancement occurs at an optimal rotation rate (Ta_{opt}).

Endosomal trafficking of two-pore K efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury.

Potassium efflux via the two-pore K channel TWIK2 is a requisite step for the activation of NLRP3 inflammasome, however, it remains unclear how K efflux is activated in response to select cues. Here, we report that during homeostasis, TWIK2 resides in endosomal compartments. TWIK2 is transported by endosomal fusion to the plasmalemma in response to increased extracellular ATP resulting in the extrusion of K.

Is procalcitonin a reliable indicator of sepsis in spinal cord injury patients: an observational cohort study.

Study Design: Prospective observational cohort study.

Objective: To understand if serum procalcitonin (PCT) is a reliable indicator of sepsis in spinal cord injury (SCI) patients for better prognosis and earlier diagnosis when compared with other common biomarkers such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cells (WBC), blood culture and body temperature.

Methods: From March 2021 to August 2022, data were collected for SCI patients who developed septicaemia.

The impact of aerosol box on tracheal intubation during the COVID-19 pandemic: a systematic review.

Introduction: This study aimed to summarize the effect of the aerosol box on tracheal intubation in patients with COVID-19.

Areas Covered: According to the PRISMA guidelines, a systematic search was performed to identify relevant literature on the 'impact of the aerosol box on tracheal intubation during the COVID-19 pandemic' in different electronic databases up to March 2021. Based on a set of predefined inclusion and exclusion criteria, 447 articles were screened.

Deregulated transcription factors in cancer cell metabolisms and reprogramming.

Metabolic reprogramming is an important cancer hallmark that plays a key role in cancer malignancies and therapy resistance. Cancer cells reprogram the metabolic pathways to generate not only energy and building blocks but also produce numerous key signaling metabolites to impact signaling and epigenetic/transcriptional regulation for cancer cell proliferation and survival. A deeper understanding of the mechanisms by which metabolic reprogramming is regulated in cancer may provide potential new strategies for cancer targeting.

Duty to Work During the COVID-19 Pandemic: A Cross-Sectional Study of Perceptions of Health Care Providers in Jordan.

Introduction: This study aimed to assess perceptions of duty to work among health care providers during the coronavirus disease 2019 response and to identify factors that may influence their perceptions.

Methods: This was a cross-sectional study conducted from April 1, 2020, to April 20, 2020, using an online survey distributed to health care providers in Jordan. Descriptive statistics were used, as well as chi-square test for independence to assess relationships between variables.

Synthesis, biological evaluation, Structure - Activity relationship studies of quinoline-imidazole derivatives as potent antimalarial agents.

In our efforts to identify novel chemical scaffolds for the development of antimalarial agents, a series of quinoline - imidazole hybrid compounds were synthesized and their blood-stage antimalarial activity was evaluated in both drug-sensitive and -multi drug-resistant (MDR) P. falciparum strains. The new analogs possess sub-micromolar activities against Plasmodium falciparum.

Adenine Modification at C7 as a Viable Strategy to Potentiate the Antimalarial Activity of Quinolones.

Although many quinolones have shown promise as potent antimalarials, their clinical development has been slow due to poor performance in vivo. Insights into structural modifications that can improve their therapeutic potential will be very valuable in this vibrant area of research. Our studies involving a library of quinolones which vary in substitution pattern at N1, C3, C6 and C7 positions have shown that the presence of adenine moiety at C7 can bring a noticeable improvement in activity compared to other heterocyclic groups at this location.

Psychological impacts during the COVID-19 outbreak among adult population in Jordan: A cross-sectional study.

In response to the initial outbreak of the Coronavirus Disease 2019 (COVID-19) pandemic and the pandemic-related restraints and preventive measures implemented, the global population has been experiencing a wide range of immediate psychological reactions, such as fear and psychological distress. The present study aimed to assess the psychological impacts of the COVID-19 pandemic among a sample of adults during the national lockdown implemented in Jordan. A quantitative, descriptive, correlational, cross-sectional design was used.

Psychometric Properties of the Arabic Version of the Fear of COVID-19 Scale (FCV-19S) Among Jordanian Adults.

There is an urgent need to assess the impacts of the Coronavirus-19 disease (COVID-19) outbreak on mental health among the general population such as the Fear of COVID-19. The current study aimed to provide further validation of the Arabic version of the Fear of COVID-19 Scale (FCV-19S) for use among Jordanian adults. A cross-sectional study was conducted using an anonymous online survey between 1 and 12 May 2020.

Depression, coping skills, and quality of life among Jordanian adults during the initial outbreak of COVID-19 pandemic: cross sectional study.

Little is known about the immediate psychological impacts of the national lockdown implemented during the COVID-19 pandemic on the general population in Arab countries like Jordan. The aim of this study was to assess the levels of depression, coping skills, and quality of life and their correlates among a sample of Jordanian adults aged ≥18 years during the COVID-19 lockdown implemented in Jordan. A quantitative, descriptive, correlational, cross-sectional design was conducted using an anonymous online self-report survey to collect data on participants' demographics, depression, coping skills, and quality of life.

Impact of Sodium Alginate Packaging Film Synthesized Using Seed Extract on Multi Drug Resistant Isolated from Raw Buffalo Meat.

A total of 50 were isolated from buffalo meat and their antibiotic profiling was carried out. 90% isolates showed resistant to two or more classes of 21 commonly used antibiotics. Moreover, there was also variation in resistance/sensitivity behavior towards antibiotics.

Quantifying the impact of COVID-19 preventive measures on traffic in the State of Qatar.

Ever since the beginning of 2020, the mobility of people and goods all over the world has been extremely limited as a result of movement restrictions imposed by local authorities as part of several other efforts to stop the wide spread of COVID-19 pandemic. The Supreme Committee for Crisis Management in the State of Qatar adopted the policy of incremental preventive measures that were adjusted based on the pandemic status. These actions involved several restrictions, aiming a balance between reducing the pandemic spread and the typical daily activities disturbance.

Traditional Nutritional and Health Practices Targeting Lifestyle Behavioral Changes in Humans.

In this 21st century who isn't enticed by the glamorous and appealing life in the fast lane? We are surrounded by wonders, something we could never have imagined erstwhile. We have everything just a click or a call away. This alluring lifestyle comes with its own perils, the biggest one being concerned with health which is often compromised with check ins and home delivered food but the problem doesn't just lie with the outside food but also with all those chemical enriched engineered expensive food items.

Structural-functional diversity of malaria parasite's PfHSP70-1 and PfHSP40 chaperone pair gives an edge over human orthologs in chaperone-assisted protein folding.

Plasmodium falciparum, the human malaria parasite harbors a metastable proteome which is vulnerable to proteotoxic stress conditions encountered during its lifecycle. How parasite's chaperone machinery is able to maintain its aggregation-prone proteome in functional state, is poorly understood. As HSP70-40 system forms the central hub in cellular proteostasis, we investigated the protein folding capacity of PfHSP70-1 and PfHSP40 chaperone pair and compared it with human orthologs (HSPA1A and DNAJA1).

Protein quality control machinery in intracellular protozoan parasites: hopes and challenges for therapeutic targeting.

Intracellular protozoan parasites have evolved an efficient protein quality control (PQC) network comprising protein folding and degradation machineries that protect the parasite's proteome from environmental perturbations and threats posed by host immune surveillance. Interestingly, the components of PQC machinery in parasites have acquired sequence insertions which may provide additional interaction interfaces and diversify the repertoire of their biological roles. However, the auxiliary functions of PQC machinery remain poorly explored in parasite.

Mutagenicity and genotoxicity evaluation of textile industry wastewater using bacterial and plant bioassays.

Textile industrial wastewater samples were taken from the Panki site 5 industrial area of Kanpur city, India. Atomic Absorption spectrophotometer and Gas Chromatography-Mass spectrometry techniques have shown that the wastewater contained several heavy metals and organic pollutants (Khan and Malik, 2017) [1]. Further, in order to explore the potential toxicity of these pollutants present in the effluent, a battery of short-term biological assays (Ames test, DNA repair defective mutation assay and chromosomal aberration test) were used.

Investigating Pharmacological Targeting of G-Quadruplexes in the Human Malaria Parasite.

The unique occurrence of G-quadruplexes in the AT-rich genome of human malaria parasite Plasmodium falciparum provides hints about their critical roles in parasite survival, pathogenesis, and host immune evasion. An intriguing question is whether these noncanonical structures can serve as molecular targets for small molecule-based interventions against malaria. In this study, we have investigated the pharmacological targeting of G-quadruplexes for parasite inhibition.