Reconfigurable nanophotonic silicon probes for sub-millisecond deep-brain optical stimulation.

The use of nanophotonics to rapidly and precisely reconfigure light beams for the optical stimulation of neurons in vivo has remained elusive. Here we report the design and fabrication of an implantable silicon-based probe that can switch and route multiple optical beams to stimulate identified sets of neurons across cortical layers and simultaneously record the produced spike patterns. Each switch in the device consists of a silicon nitride waveguide structure that can be rapidly (<20 μs) reconfigured by electrically tuning the phase of light.

3D microphotonic probe for high resolution deep tissue imaging.

Ultra-compact miniaturized optical components for microendoscopic tools and miniaturized microscopes are required for minimally invasive imaging. Current microendoscopic technologies used for deep tissue imaging procedures are limited to a large diameter and/or low resolution due to manufacturing restrictions. We demonstrate a platform for miniaturization of an optical imaging system for microendoscopic applications with a resolution of 1 µm.

Microphotonic needle for minimally invasive endoscopic imaging with sub-cellular resolution.

Ultra-compact micro-optical elements for endoscopic instruments and miniaturized microscopes allow for non-invasive and non-destructive examination of microstructures and tissues. With sub-cellular level resolution such instruments could provide immediate diagnosis that is virtually consistent with a histologic diagnosis enabling for example to differentiate the boundaries between malignant and benign tissue. Such instruments are now being developed at a rapid rate; however, current manufacturing technologies limit the instruments to very large sizes, well beyond the sub-mm sizes required in order to ensure minimal tissue damage.

Polymer waveguide Fabry-Perot resonator for high-frequency ultrasound detection.

Piezoelectric technology is the backbone of most medical ultrasound imaging arrays; however, signal transduction efficiency severely deteriorates in scaling the technology to element size smaller than 0.1 mm, often required for high-frequency operation (>20 MHz). Optical sensing and generation of ultrasound has been proposed and studied as an alternative technology for implementing sub-millimeter size arrays with element size down to 10 μm.

High quality factor polymeric Fabry-Perot resonators utilizing a polymer waveguide.

Optical resonators are used in a variety of applications ranging from sensors to lasers and signal routing in high volume communication networks. Achieving a high quality (Q) factor is necessary for higher sensitivity in sensing applications and for narrow linewidth light emission in most lasing applications. In this work, we propose a new approach to achieve a very high Q-factor in polymeric Fabry-Perot resonators by conquering light diffraction inside the optical cavity.

Optical micromachined ultrasound transducers (OMUT)--a new approach for high-frequency transducers.

The sensitivity and reliability of piezoelectric ultrasound transducers severely degrade in applications requiring high frequency and small element size. Alternative technologies such as capacitive micromachined ultrasound transducers (CMUT) and optical sensing and generation of ultrasound have been proposed and studied for several decades. In this paper, we present a new type of device based on optical micromachined ultrasound transducer (OMUT) technology.