Dynamic corneal biomechanics in different cell layers: in keratoconus and normal eyes.

Purpose: This study aimed to determine the relationship between corneal cellular structures and biomechanical deformation parameters in keratoconic (KC) and healthy eyes.

Methods: In this prospective comparative study, 29 eyes of 29 KC patients were age- and gender-matched with 28 eyes of 28 healthy individuals using frequency matching. Corneal parameters examined included the density of basal epithelial cells, anterior keratocytes, posterior keratocytes and endothelial cells as assessed by in vivo corneal confocal microscopy (HRT III-RCM, Heidelberg Engineering, www.

Post-LASIK Ectasia Versus Keratoconus: An In Vivo Confocal Microscopy Study.

Purpose: To examine and compare corneal cellular and subbasal nerve (SBN) characteristics in post-laser-assisted in situ keratomileusis ectasia (PLE) corneas, normal post-laser-assisted in situ keratomileusis corneas (PLC), keratoconus (KC) corneas, and normal virgin corneas (NC).

Methods: In this cross-sectional comparative study, 18 PLE eyes of 11 patients, 18 PLC of 15 cases, 32 KC eyes of 32 patients, and 29 NC of 29 subjects were assessed using in vivo confocal microscopy. The density of the basal epithelial cell (BEC), anterior keratocyte, posterior keratocyte, and endothelial cell layers, as well as the characteristics of SBN fibers, was compared between the 4 groups.

Duration of topical steroid application after photorefractive keratectomy with mitomycin C.

Contradictory results of postoperative steroid application in photorefractive keratectomy (PRK) led to a meta-analysis of the existing data to achieve a definite conclusion on the optimum dosage and duration of corticosteroid therapy after PRK. The overall pooled unstandardized mean difference (PUMD) of the corneal haze score was -0.20 (95% CI, -0.

Keratoconus detection by novel indices in patients with Down syndrome: a cohort population-based study.

Purpose: To use novel indices to determine the prevalence of KC and its progression in patients aged 10-30 years with Down syndrome.

Study Design: Cohort population-based study.

Methods: Two hundred twenty-six of 250 invited Down syndrome patients were enrolled.

Multipoint assessment of demarcation line depth after standard and accelerated cross-linking in central and inferior keratoconus.

Purpose: To determine the changes in the depth of the demarcation line in the central to peripheral cornea following accelerated compared to standard corneal cross-linking (CXL).

Methods: In this prospective, non-randomized study, 60 eyes with progressive keratoconus underwent accelerated or standard CXL (30 in each group). Anterior segment optical coherence tomography (AS-OCT) was done one month later by two independent masked examiners to measure the depth of the demarcation line in the central cornea and on peripheral rings.

One Year Outcomes of Photorefractive Keratectomy with the Application of Mitomycin-C in the Treatment of Mild to Moderate Hyperopia.

Purpose: To evaluate refractive and visual outcomes of photorefractive keratectomy with mitomycin-C. (PRK-MMC) for the treatment of mild to moderate hyperopia.

Materials And Methods: This case series enrolled 21 patients with up to +5.

Long-term Results of an Accelerated Corneal Cross-linking Protocol (18 mW/cm2) for the Treatment of Progressive Keratoconus.

Purpose: To compare the long-term outcomes of accelerated and standard corneal cross-linking protocols in the treatment of progressive keratoconus.

Design: Prospective randomized clinical trial.

Methods: Thirty-one eyes with keratoconus were treated with an accelerated protocol (18 mW/cm(2), 5 min) and all contralateral eyes were treated with the standard method (3 mW/cm(2), 30 min) using the same overall fluence of 5.

Short-term comparison of accelerated and standard methods of corneal collagen crosslinking.

Purpose: To compare the 6-month results of accelerated and standard collagen crosslinking (CXL) treatment of progressive keratoconus.

Setting: Noor Eye Hospital, Tehran, Iran.

Design: Prospective randomized clinical trial.

Clinical results with two different pharmaceutical preparations of riboflavin in corneal cross-linking: an 18-month follow up.

Background: Comparison of long-term clinical results of two different pharmaceutical formulations used in corneal cross-linking (CXL) in keratoconus patients.

Methods: Sixty eyes of 60 keratoconus patients underwent CXL in two groups. We used riboflavin preparations from Sina Darou, Iran in group A, and Streuli Pharma, Switzerland in group B.

Comparison of clinical results of two pharmaceutical products of riboflavin in corneal collagen cross-linking for keratoconus.

Background: To compare the 6-month results of two formulations of Riboflavin provided by Sina Darou, Iran, and Uznach, Switzerland, in corneal collagen cross-linking (CXL) for keratoconus patients.

Findings: Considering the results of the previous study about the similarity of the formulations and the active ingredients of the two types of Riboflavin, they were used in the CXL procedure of 60 keratoconic eyes (30 eyes in each group). After 6 months, the mean improvement of UCVA (0.

Corneal collagen cross-linking with riboflavin and ultraviolet a irradiation for keratoconus: long-term results.

Purpose: To evaluate the long-term results of corneal collagen cross-linking (CXL) in patients with progressive keratoconus.

Design: Prospective case series.

Participants: This study was conducted on 40 eyes of 32 patients with progressive keratoconus between 2006 and 2012.

Confocal microscopy of corneal stroma and endothelium after LASIK and PRK.

Purpose: To compare with confocal microscopy the changes in stromal keratocyte density and endothelial cell count due to photorefractive keratectomy (PRK) and LASIK.

Methods: In this prospective study, 32 eyes (16 myopic patients) were examined with the NIDEK Confoscan 3 confocal microscope before and 6 months after PRK and LASIK. The preoperative mean myopia was -2.