Publications by authors named "Mohammad Amin Khishvand"
Biomed Res Int
October 2024
Article Synopsis
- Resveratrol (RSV) is being researched for its potential in treating neurodegenerative diseases, but its effectiveness is limited due to low oral bioavailability, which this study aimed to improve by encapsulating it in solid lipid nanoparticles (SLNs).
- The RSV-SLNs were created using a solvent emulsification-evaporation technique and analyzed for their size, efficiency, and drug loading characteristics, displaying favorable properties for potential therapeutic use.
- In behavioral and biochemical tests on rats, RSV-SLNs showed greater neuroprotective effects compared to free RSV, evidenced by reduced escape latency in the Morris water maze, decreased lipid peroxidation, increased glutathione levels, and improved neural cell morphology in histological examinations.
