Combined use of direct renin inhibitor and carvedilol in heart failure with preserved systolic function.

Hypotheses: Heart failure with preserved systolic function (HFPSF) has attained epidemic proportions; however evidence-based therapeutic interventions have not advanced despite continued research over the past three decades. We propose the combined use of direct renin inhibitor and carvedilol for this condition.

Rationale: The Renin Angiotensin Aldosterone System (RAAS) plays a central role in myocyte hypertrophy, fibrosis and ventricular remodeling which is responsible for the diastolic dysfunction in HFPSF.

Prevalence, determinants, and clinical significance of cardiac troponin-I elevation in individuals admitted for a hypertensive emergency.

Hypertensive emergencies (HEs) are frequently accompanied with the release of cardiac troponin I (cTnI); however, determinants and clinical significance of cTnI elevation are largely unknown. A retrospective analysis was performed on patients (n = 567) with a diagnosis of HE admitted to two tertiary care centers that primarily serve an inner-city population. Data on demographics, clinical variables, and cTnI were collected through chart review.

Relation of heart rate with cardiovascular disease in normal-weight individuals: the Chicago Heart Association Detection Project in Industry.

The authors investigated the association of resting heart rate (RHR) with cardiovascular disease (CVD) risk factors and mortality among normal-weight individuals. Using data from our cohort (baseline examination in 1967-1973), individuals with a body mass index of 18.5 to 24.

The association of heart rate recovery immediately after exercise with coronary artery calcium: the coronary artery risk development in young adults study.

We tested whether slower heart rate recovery (HRR) following graded exercise treadmill testing (GXT) was associated with the presence of coronary artery calcium (CAC). Participants (n = 2,648) ages 18-30 years at baseline examination underwent GXT, followed by CAC screening 15 years later. Slow HRR was not associated with higher odds of testing positive (yes/no) for CAC at year 15 (OR = 0.

The temporal relationship between heart rate recovery immediately after exercise and the metabolic syndrome: the CARDIA study.

Aims: Slower heart rate recovery (HRR) following exercise is associated with the metabolic syndrome, yet the temporal relationship between the two remains unknown. We investigated the cross-sectional and longitudinal associations of slower HRR following a graded exercise treadmill test (GXT) with metabolic syndrome components and LDL-C.

Methods And Results: Participants aged 18-30 from the Coronary Artery Risk Development in Young Adults study underwent a symptom-limited maximal GXT at baseline (n = 4319) and 7 years later.