Targeting transcriptional regulatory protein RfaH with natural compounds to develop novel therapies against .

The growing threat of antibiotic-resistant infections demands novel treatment strategies. This study focuses on the transcriptional regulatory protein RfaH, a protein crucial for the bacteria's virulence by promoting gene expression for its capsule, cell wall, and pilus. As becomes resistant to existing antibiotics, targeting RfaH with specific inhibitors offers a promising alternative.

Dyschromatopsia and contrast sensitivity changes in COVID-19 patients.

Purpose: To evaluate the alterations in the psycho-physical tests, contrast sensitivity (CS) and hue discrimination (total estimation score, TES) in COVID-19 patients.

Methods: A prospective case-control study was undertaken in 2021-22 to look at CS and TES among COVID-19 patients and RT-PCR negative normal subjects by a mobile app "smart optometry" and X-Rite's free online version of Farnsworth-Munsell 100 hue test. Strict visual acuity (minimum of 6/9 equivalent on Snellen) and other clinical parameters were used as exclusion criteria to filter potentially confounding pre-receptoral co-morbid conditions.

Prevalence and antimicrobial susceptibility of spp. in a tertiary care hospital in Peshawar: a cross-sectional study.

Unlabelled: spp. have been a primary cause of nosocomial infections worldwide, causing significant morbidity and mortality, especially in Pakistan. The purpose of this study was to investigate the trend of antimicrobial resistance over a 5-year period in a tertiary care hospital in Pakistan.

A study on the shelf life of cookies incorporated with sapota and beetroot leaf powders.

The addition of edible fiber could affect the shelf life of cookies, which can have a positive or negative impact depending on the source of fiber. This study is in continuation of two previously published papers to investigate the storage stability of cookies incorporated with 4.5% beetroot leaf powder (BLP), with 7% sapota fiber powder (SFP) and reference cookies during 15 months at ambient temperature by analyses of physicochemical, microbial and sensory properties on each specified month using international standard methods.

Antimicrobial activity of different plants extracts against Staphylococcus aureus and Escherichia coli.

Background: Microbial pathogens, mainly bacteria, are a major cause of food spoilage resulting in several foodborne diseases. Food spoilage can be prevented by the application of chemical preservatives in the food industry but such process has harmful effects on human health and causes the introduction of chemicals in several food chains, leading to toxicity and long-term complications. Due to such adverse effects, the need to find natural preservatives that are safer to use, effective and less complicated is increasing.

Development and quality evaluation of cookies supplemented with concentrated fiber powder from chiku ().

The aim of this study was to investigate the physicochemical, textural and organoleptic attributes of developed cookies containing concentrated chiku fiber powder (CChFP) () at different levels (0, 4.5, 7, 9.5, 12%).

Graphene/Nickel Oxide-Based Nanocomposite of Polyaniline with Special Reference to Ammonia Sensing.

Polyaniline@graphene/nickel oxide (Pani@GN/NiO), polyaniline/graphene (Pani/GN), and polyaniline/nickel oxide (Pani/NiO) nanocomposites and polyaniline (Pani) were successfully synthesized and tested for ammonia sensing. Pani@GN/NiO, Pani/NiO, Pani/GN, and Pani were characterized using X-ray diffraction, UV-vis spectroscopy, Raman spectroscopy, scanning electron microscopy, and transmission electron microscopy. The as-prepared materials were studied for comparative dc electrical conductivity and the change in their electrical conductivity on exposure to ammonia vapors followed by ambient air at room temperature.

Increased Waitlist Mortality and Lower Rate for Liver Transplantation in Hispanic Patients With Primary Biliary Cholangitis.

Background & Aims: Data on the differences in ethnicity and race among patients with primary biliary cholangitis (PBC) awaiting liver transplantation (LT) are limited. We evaluated liver transplant waitlist trends and outcomes based on ethnicity and race in patients with PBC in the United States.

Methods: Using the United Network for Organ Sharing (UNOS) registry, we collected data on patients with PBC on the liver transplant waitlist, and performed analysis with a focus on ethnicity and race-based variations clinical manifestations, waitlist mortality and LT rates from 2000 to 2014.

The Role of Neighborhood Environment in Promoting Risk Factors of Cardiovascular Disease among Young Adults: Data from Middle to High Income Population in an Asian Megacity.

Background: Modifiable risk factors of cardiovascular diseases (CVD) have their triggers in the neighborhood environments of communities. Studying the environmental triggers for CVD risk factors is important to understand the situation in a broader perspective. Young adults are influenced the most by the environment profile around them hence it is important to study this subset of the population.

Intraoperative monitoring of the recurrent laryngeal nerve using acoustic, free-run, and evoked electromyography.

The purpose of this study was to explore advantages and disadvantages of electrodes used for monitoring of the recurrent laryngeal nerve (RLN) and to determine the postoperative outcome in 135 patients. A pilot study examined 11 patients to compare the clinical performance of two commercially available recording electrodes and three stimulation electrodes for RLN neuromonitoring. After determining the most reliable and consistent stimulating/recording electrode combination, 124 patients were then monitored.

Cinnamon improves glucose and lipids of people with type 2 diabetes.

Objective: The objective of this study was to determine whether cinnamon improves blood glucose, triglyceride, total cholesterol, HDL cholesterol, and LDL cholesterol levels in people with type 2 diabetes.

Research Design And Methods: A total of 60 people with type 2 diabetes, 30 men and 30 women aged 52.2 +/- 6.