Publications by authors named "Mohammad Al-Refai"
Article Synopsis
- Genetic and epigenetic factors play a significant role in increasing the risk of relapse in substance use disorders (SUD), but a thorough investigation of these factors is still needed.
- The review examines various genetic polymorphisms and epigenetic changes (like histone modifications and DNA methylation patterns) linked to SUD relapse, focusing on specific genes like DRD2, GABRA2, and COMT.
- Findings suggest that factors such as CpG hypermethylation in certain genes are connected to severe alcohol use disorder and highlight the need for more research to understand these relationships and improve treatment strategies.
Background: Soil-transmitted diseases are caused by intestinal worms transmitted various routes into the human body resulting in various clinical manifestations. This study aimed to investigate the socio-demographic factors contributing mainly to the prevalence of soil-transmitted helminths (STHs) among newly arrived laborers in Jeddah, Saudi Arabia.
Methods: A total of 188 stool specimens were collected and examined macroscopically and microscopically using different techniques.
Background: Diversity in clinical signs and symptoms are associated with soil transmitted diseases (STD), which are spread to humans by intestinal worms and transmitted in a variety of ways. There is a need for the present study, which aimed to investigate the prevalence of intestinal parasites and to compare between the common detection techniques for soil-transmitted helminths (STHs) among newly arrived expatriate labors in Jeddah, Saudi Arabia.
Methods: A total of 188 stool samples were analyzed by macroscopic examination, and microscopic examination using direct iodine smear and the formal ether sedimentation technique.
Role of Noncanonical Wnt Signaling Pathway in Human Aortic Valve Calcification.
Arterioscler Thromb Vasc Biol
March 2017
Objective: The mechanisms underlying the pathogenesis of aortic valve calcification remain unclear. With accumulating evidence demonstrating that valve calcification recapitulates bone development, the crucial roles of noncanonical Wnt ligands WNT5a, WNT5b, and WNT11 in osteogenesis make them critical targets in the study of aortic valve calcification.
Approach And Results: Using immunohistochemistry, real-time qPCR, Western blotting, and tissue culture, we examined the tissue distribution of WNT5a, WNT5b, and WNT11 in noncalcified and calcified aortic valves and their effects on human aortic valve interstitial cells (HAVICs).