Publications by authors named "Mohammad Al-Mofarreh"
Background: The role of microbiota in the pathogenesis of ulcerative colitis (UC) has been increasingly recognized. However, most of the reports are from Western populations. In Middle Eastern countries, including Saudi Arabia, little is known about the role of microbiota.
View Article and Find Full Text PDFBackground: Intestinal dysbiosis has been reported to be associated with celiac disease (CeD) in Western populations but little is known in other populations who have different dietary lifestyle and genetic background. The purpose of this study was to determine whether a different microbiota profile is associated with CeD in children in Saudi Arabia.
Results: Forty children with CeD, 20 healthy controls, and 19 non-CeD controls were enrolled.
Article Synopsis
- * This study analyzed the viral profiles from fecal and mucosal samples of 40 children with new-onset CeD and 39 healthy controls, finding distinct viral dysbiosis in the CeD group.
- * Although specific viral species were found to be more or less abundant in the fecal samples of children with CeD, mucosal samples did not show significant associations, highlighting the complexity of viral interactions in gut health and the need for more research.
Background: Although intestinal fungi are known to interact with the immune system, the relationship between intestinal fungi and childhood celiac disease (CeD), an immune-mediated condition, has rarely been reported.
Aims: The aim of this study was to describe gut fungal profiles in a cohort of children with new-onset CeD.
Methods: Mucosal and fecal samples were collected from children with CeD and controls and subjected to metagenomics analysis of fungal microbiota communities.
Background/aim: Delay in the diagnosis of inflammatory bowel disease (IBD) is associated with complications. Our aim was to describe the pattern and risk factors associated with delay in the diagnosis of IBD in Saudi children.
Patients And Methods: This was a multicenter study with a retrospective/prospective design.
Background: The role of microbiota in Crohn's disease (CD) is increasingly recognized. However, most of the reports are from Western populations. Considering the possible variation from other populations, the aim of this study was to describe the microbiota profile in children with CD in Saudi Arabia, a non-Western developing country population.
View Article and Find Full Text PDFFungal dysbiosis predicts the diagnosis of pediatric Crohn's disease.
World J Gastroenterol
October 2018
Article Synopsis
- The study aimed to assess the effectiveness of fungal dysbiosis in mucosal and stool samples for predicting Crohn's disease (CD) in children.
- Conducted in Saudi Arabia, the research involved 15 children with CD and 20 controls, analyzing their samples to determine fungal abundance and diversity using advanced sequencing methods.
- Results showed that the prediction accuracy was notably higher for stool samples (mean AUC = 0.85) compared to mucosal samples (mean AUC = 0.71), indicating that stool analysis may be more reliable for diagnosing CD in children.
Background/aim: Inflammatory bowel disease (IBD) is increasing in Saudi Arabia but there's little knowledge about its risk factors. Our aim is to investigate the dietary risk factors of this disease in Saudi children.
Patients And Methods: The children investigated for IBD were prospectively enrolled.
Article Synopsis
- The study investigates the characteristics of fungal microbiota in children newly diagnosed with Crohn's disease (CD) compared to non-IBD controls, emphasizing a need for more research in this area.
- It was found that certain fungi, like Psathyrellaceae and Gymnopilus, were significantly more abundant in children with CD, while others, like Monilinia, were depleted.
- Despite observing significant differences in specific fungal taxa, no overall difference in fungal diversity between the CD patients and controls was noted, indicating a complex relationship that warrants further investigation.
Background/aim: Linear growth impairment (LGI) is one of the most important features peculiar to children with inflammatory bowel disease (IBD). The aim of this report is to define the impact of IBD on the linear growth of children in the Kingdom of Saudi Arabia (KSA).
Setting And Design: Multicenter retrospective study.
Background and Aims. Crohn's disease (CD) is an evolving disease in KSA. Little is known about its characteristics in the Saudi population.
View Article and Find Full Text PDFAim: To assess the prevalence of nutritional disorders in children with inflammatory bowel disease (IBD) in Saudi Arabia.
Methods: The data from a national cohort of children newly diagnosed with IBD between 2003 and 2012 were analyzed. The diagnosis of IBD and the differentiation between Crohn's disease (CD) and ulcerative colitis (UC) were confirmed by gastroenterologists according to the standard criteria.
Background: Pediatric inflammatory bowel disease (IBD) is increasingly recognized in developing countries; however, the incidence and trend over time have not been reported.
Methods: This retrospective study included children diagnosed with IBD in gastroenterology centers in the Kingdom of Saudi Arabia between 2003 and 2012. The date of birth, date and age at diagnosis, gender, and final diagnosis were collected on special forms.
Emerging inflammatory bowel disease in saudi outpatients: a report of 693 cases.
Saudi J Gastroenterol
July 2013
Background/aim: Inflammatory bowel disease (IBD) is a chronic disease of unknown etiology and considered traditionally as a disease of the western world. Recently, rising trends have been observed in countries previously known to have a low prevalence and incidence. The aim of this study is to collect epidemiological data on IBD outpatients and to add data from the Kingdom of Saudi Arabia (KSA) to the available IBD literature.
View Article and Find Full Text PDFConsanguinity and inflammatory bowel diseases: is there a relation?
J Pediatr Gastroenterol Nutr
February 2013
Objective: The aim of the present study was to investigate the relation between consanguinity and inflammatory bowel diseases (IBD).
Methods: Review of the medical records of children with a final diagnosis of IBD to determine age, sex, and type of IBD, supplemented by information on consanguinity and family history (FH) of IBD in relatives. There were 138 children, ages 1.
Background/aim: To determine the epidemiology of Crohn's disease (CD) in an outpatient clinic and compare it with data previously reported from different centers in the Kingdom of Saudi Arabia and outside.
Materials And Methods: The medical records of all patients with CD seen in the clinic in the period from January 1993 through December 2007 were reviewed. The demographic, clinical data and methods of diagnosis were retrieved.
Aim: To report present state of iatrogenic drug-induced esophageal injury (DIEI) induced by medications in a private clinic.
Methods: Iatrogenic drug-induced esophageal injury (DIEI) induced by medications has been more frequently reported. In a private clinic we encountered 36 cases of esophageal ulcerations complicating doxycycline therapy in a mainly younger Saudi population (median age 29 years).
Gammaglutamyl transpeptidase activity in patients with schistosomiasis.
Saudi J Gastroenterol
January 2003
Background: Schistosoma mansoni infestation may induce liver fibrosis and portal hypertension, with possible elevation of liver enzymes.
Aim Of The Study: The aim of this study was to evaluate the serum gammaglutamyl transpeptidase (GGT) activity in a group of non-alcoholic and non-obese patients with hepatointestinal schistosomiasis.
Patients And Methods: Medical records of 174 patients diagnosed to have hepatointestinal schistosomiasis on the basis of clinical and laboratory data were reviewed.