Complete genome sequence of a novel bipartite begomovirus infecting butterfly pea (Clitoria ternatea L.) in India.

In India, plants from the non-cultivated, horticultural, and agricultural categories are commonly infected with various begomoviruses, most of which produce yellow mosaic, bright yellow mosaic, or curling symptoms on leaves. In this study, the complete genome of a new bipartite begomovirus causing yellow mosaic disease (YMD) in butterfly pea (Clitoria ternatea L.) was characterized using rolling-circle amplification followed by restriction digestion, cloning, and sequencing to obtain the full-length DNA-A (2727 nt) and DNA-B (2648 nt) sequences.

Exploring distribution and genomic diversity of begomoviruses associated with yellow mosaic disease of legume crops from India, highlighting the dominance of mungbean yellow mosaic India virus.

Yellow mosaic disease (YMD) caused by several begomoviruses is one of the major constraints of over a dozen leguminous crops worldwide, particularly in Asian and Southeast Asian countries. The present study aimed to investigate the distribution, diversity and prevalence of begomoviruses associated with YMD in leguminous hosts in five agro-climatic zones of India, to assess the extent of their geographical presence and develop location and crop-specific distribution maps. One hundred and seventy-four leguminous plant samples were tested from 32 locations in India to detect YMD-causing viruses.

Concurrent chemoradiation with low-dose and long-duration weekly infusion of gemcitabine in unresectable squamous cell carcinoma of head and neck (SCCHN).

Background: Concurrent chemoradiotherapy now represents the standard of care in locally advanced unresectable squamous cell carcinoma of the head and neck, and the administration of cisplatin in triweekly or weekly schedules is the most commonly used chemotherapeutic agent. However, the chemotherapeutic agent and its scheduling with radiation is still an area of investigation with safer toxicity profile and better response rates. Gemcitabine is a potent radiosensitizer, and non-cytotoxic concentration results in decreased systemic toxicity while maintaining radiosensitization properties.

Mathematical modelling of a single tethered aerostat using longitudinal stability derivatives.

Lighter-than-air (LTA) aerial vehicles such as airships and aerostats can be found in various strategic and commercial applications, primarily due to their capability to hover and stealth. The mathematical model of these vehicles helps in understanding their complex dynamics and designing and developing proper stabilisation systems for them. Stability derivatives have been used for developing mathematical models for heavier-than-air aerial vehicles since their introduction.

A fully-flexible and thermally adjustable implantable neural probe with a U-turn polyester microchannel.

This work presents a fully flexible implantable neural probe fabricated with Polydimethylsiloxane (PDMS) and including a thermally-tunable stiffness microchannel filled with Polyester. The probe includes an optimized microfluidics mixer for drug delivery. Polyester, which is solid at room temperature and has a low melting point close to body temperature, is used to decrease the stiffness of the probe after insertion, after getting in contact with tissues.

Urdbean Leaf Crinkle Virus: A Mystery Waiting to Be Solved.

Urdbean leaf crinkle disease (ULCD) affects mainly the urdbean or blackgram ( (L.) Hepper) causing distinct symptoms that often result in serious yield losses. It has been known to occur for more than five decades and is considered to be of viral etiology.

Investigation of a two-dimensional photovoltaic thermal system using hybrid nanofluids and a rotating cylinder.

This article focuses on a numerical investigation aimed at enhancing the electrical performance of a two-dimensional photovoltaic thermal system (PV/T) through the application of cooling using hybrid nanofluids. The hybrid nanofluids consist of titanium oxide and silver nanoparticles suspended in water, while the PV/T system is based on polycrystalline silicon, copper, and a flow channel with a rotating cylinder. PV/T devices generate electricity from sunlight, but their performance degrades over time due to the heat generated by solar radiation.

Irreversibility analysis of hydromagnetic nanofluid flow past a horizontal surface via Koo-Kleinstreuer-Li (KKL) model.

The goal of this research is to investigate the effects of Ohmic heating, heat generation, and viscous dissipative flow on magneto (MHD) boundary-layer heat transmission flowing of Jeffrey nanofluid across a stretchable surface using the Koo-Kleinstreuer-Li (KKL) model. Engine oil serves as the primary fluid and is suspended with copper oxide nanomolecules. The governing equations that regulate the flowing and heat transmission fields are partial-differential equations (PDEs) that are then converted to a model of non-linear ordinary differential equations (ODEs) via similarity transformation.

Enhancement of Film Cooling Effectiveness in a Supersonic Nozzle.

Film cooling as applied to rocket nozzles is analyzed numerically with emphasis on the assessment of the effect of the mixing of coolant with the hot stream. Cooling performance, as characterized by cooling effectiveness, is studied for three different coolants in the three-dimensional, turbulent flow field of a supersonic convergent-divergent nozzle operating with a hot stream temperature of 2500 K over a range of blowing ratios. The coolant stream is injected tangentially into the mainstream using a diffuser-type injector.

Age-wise cancer incidence in western Uttar Pradesh in India: An observational study.

Context: According to the World Health Organization report of 2011, the main cause of death was cancer rather than heart diseases. 14.1 million new cases and about 8.

[Delirium after electroconvulsive therapy].

Background: Transient, acute delirium after electroconvulsive therapy (ECT) occurs in approximately one in eight patients. This case report describes a man with no known risk factors who developed a rare form of delirium, which is of longer duration and occurs longer after electroconvulsive therapy.

Case Presentation: A man in his forties with major depression with psychosis was admitted to the acute psychiatric ward after his sixth ECT treatment.

A digital solution to streamline access to smoking cessation interventions in England; findings from a primary care pilot (STOPNOW study).

Objectives: Despite the proven efficacy of several smoking cessation medications that have been shown to improve long-term abstinence rates, approximately two-thirds of smokers report not having used medication in their most recent quit attempt. A main barrier could be delayed access to pharmacological interventions. This study investigated the utility of a primary care linked online portal to streamline timely access to pharmacological support to patients who want to quit smoking by making an asynchronous request for treatment to their general practitioner.

Fluorescent spectroscopic assessment before and after radiation treatment in oral cavity cancer and its clinical correlation.

Background: Biochemical changes in irradiated malignant tissue lead to altered autofluorophores status which should be different for cancerous tissue (residual/recurrence) and irradiated normal tissue. If this irradiated tissue is examined through fluorescent spectroscopy, we can find the spectroscopic changes occurring after the completion of treatment which can be helpful in evaluating treatment response.

Methods: Punch biopsy sample was examined through fluorescent spectroscopy in oral cavity cancer patients before and after definitive radiation treatment.

Analysis of the use of antibiotics profile and factors of surgical site infections study on digestive and oncology surgeries.

Objectives: The incision method operation with a high risk of infection in a clean and clean-contaminated operation requires the use of prophylactic antibiotics to minimize the risk of infection. This study was designed to analyze the effectiveness of prophylactic antibiotics in patients with digestive and oncology surgeries.

Methods: The statistical method used was chi-square to determine the risk factors for infection at surgical site infections (SSI) in patients with digestive and oncology surgeries.

Analysis of prophylactic antibiotic use and risk factor of postoperative infection in urological surgery patients.

Objectives: The widespread use of inappropriate prophylactic antibiotics in urological surgery patients can increase the risk of resistance and development of postoperative infection. This study was aimed to analyze the quality of prophylactic antibiotics use and identify the risk factor of postoperative nosocomial infection in urological surgery patients.

Methods: Observational prospective data were obtained from patients' medical records.

Interdigitated versus sequential high-dose-rate intracavitary brachytherapy with external beam radiotherapy in locally advanced carcinoma cervix.

Aims: To decrease overall treatment time (OTT) and to compare the clinical outcome of interdigitated high-dose-rate intracavitary brachytherapy (HDRICBT) versus sequential HDRICBT with external beam radiotherapy (EBRT) in the treatment of locally advanced carcinoma cervix.

Methods: Eighty-two patients with histologically confirmed carcinoma of the cervix, untreated International Federation of Gynecology and Obstetrics Stage IIB-IIIB, were included and randomized into two groups. The study group received EBRT 50 Gy/25 fractions with interdigitated HDRICBT 8 Gy/fraction weekly a total of three fractions.

Solitary fibular metastasis from nonsmall cell lung carcinoma.

Solitary bone metastasis to fibula in patients of lung carcinoma is a rare entity, with only four cases reported in literature. We, hereby, present a case of a 50 year-old-male who was given three cycles of chemotherapy for lung carcinoma with no distant metastasis but presented 2 months later with a fusiform, painful swelling around the knee that was clinically suspected to be inflammatory in nature but proved to be fibular metastasis on cytology. There was no evidence of skeletal metastasis on initial bone scan.

Effects of CO/N dilution on laminar burning velocity of stoichiometric DME-air mixture at elevated temperatures.

The laminar burning velocity of CO/N diluted stoichiometric dimethyl ether (DME) air mixtures is determined experimentally at atmospheric pressure and elevated mixture temperatures using a mesoscale high aspect-ratio diverging channel with inlet dimensions of 25mm×2mm. In this method, planar flames at different initial temperatures (T) were stabilized inside the channel using an external electric heater. The magnitude of burning velocities was acquired by measuring the flame position and initial temperature.

In vitro antimalarial and xanthine oxidase inhibition of 2-Aminoanthraquinone.

In the present research study 2-Aminoanthraquinone were scrutinized for their antimalarial and Xanthine oxidase inhibitor potential. It demonstrated marked concentration dependent antimalarial activity with maximum effect of 89.06% and with IC50 of 34.

PREVALENCE OF UNCORRECTED REFRACTIVE ERRORS IN ADULTS AGED 30 YEARS AND ABOVE IN A RURAL POPULATION IN PAKISTAN.

Background: Uncorrected refractive errors are a leading cause of visual disability globally. This population-based study was done to estimate the prevalence of uncorrected refractive errors in adults aged 30 years and above of village Pawakah, Khyber Pakhtunkhwa (KPK), Pakistan.

Methods: It was a cross-sectional survey in which 1000 individuals were included randomly.

Papular skin lesions: Clue to a recurrence of breast cancer on fine needle non-aspiration cytology (FNNAC).

Cutaneous metastasis from underlying carcinoma is relatively uncommon in clinical practice. A high index of suspicion is required to diagnose these lesions, as these lesions can mimic benign skin lesions and clinical findings may be subtle. Fine needle aspiration cytology (FNAC) is commonly employed for diagnosing these skin lesions.

Protein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitus.

In general, proteins can only execute their various biological functions when they are appropriately folded. Their amino acid sequence encodes the relevant information required for correct three-dimensional folding, with or without the assistance of chaperones. The challenge associated with understanding protein folding is currently one of the most important aspects of the biological sciences.

Patient related factors associated with delayed reporting in oral cavity and oropharyngeal cancer.

Background: Delayed reporting resulting in advanced stage disease is a common problem in Indian cancer patients. This study analysed the impact of various sociodemographic and psychosocial factors on the delayed reporting to Healthcare Professional (HCP) in oral and oropharyngeal cancer patients.

Methods: This cross sectional observational study was conducted using a structured questionnaire.