Piezoelectric scaffold based on polycaprolactone/thermoplastic polyurethane/barium titanate/cellulose nanocrystal for bone tissue engineering.

This study presents the development of a novel piezoelectric scaffold for bone tissue engineering composed of poly(ε-caprolactone) (PCL), thermoplastic polyurethane (TPU), barium titanate (BT), and cellulose nanocrystals (CNC). PCL and TPU are considered advantageous materials because of their ease of processing, versatility in design, and ability to degrade over time; however, their inherent immiscibility poses challenges to achieving optimal porous structures. In this study, porous scaffolds were produced using gas foaming and salt leaching techniques, resulting in highly porous interconnected scaffolds exhibiting considerable elasticity that is suitable for dynamic cell culture while avoiding the use of toxic solvents.