Publications by authors named "Mohammad Abdelwahab"
Article Synopsis
- KRAS mutations require new treatment strategies since KRAS itself is hard to target; thus, researchers focus on inhibiting the downstream PI3K/AKT/mTOR pathway, which affects cancer cell growth and survival.
- However, blocking this pathway can trigger autophagy, which diminishes the effectiveness of treatments, leading to the idea that combining kinase inhibitors with autophagy inhibitors might improve outcomes.
- In experiments with breast and lung cancer cells, a combination of the drugs Dactolisib and Lys05 showed enhanced effects on cell death and proliferation compared to using either drug alone, especially in lung cancer cells (A549).
Background: Transcatheter mitral valve repair (TMVR) using the MitraClip has become a well-established interventional therapy and is usually performed in elderly patients. The objective of this study was to assess 2-year clinical outcomes of TMVR in patients aged <65 years at three heart centres with severe mitral regurgitation (MR) and no surgical options.
Methods: A retrospective study analysed data of 36 patients aged <65 years treated with TMVR .
Background: An increased risk of cancer death has been demonstrated for patients diagnosed with acute coronary syndrome (ACS). We are investigating possible geographic risk disparities.
Methods: This prospective study included 541 ACS patients who were admitted to hospitals and discharged alive in three provinces of Italy's Veneto region.
Background: Obstructive coronary artery disease (OCAD) and coronary slow flow (CSF) are frequent angiographic findings for patients that have chest pain and require frequent hospital admission. The retina provides a window for detecting changes in microvasculature relating to the development of cardiovascular diseases such as arterial hypertension or coronary heart disease.
Objectives: To assess the coronary and ocular circulations in patients with CSF and those with obstructive coronary artery disease.
Objectives: To investigate the association between 24-hr blood pressure variability (BPV) and subclinical echocardiographic changes and microalbuminuria in normotensive women with history of preeclampsia/eclampsia.
Background: Ambulatory blood pressure monitoring (ABPM) has been used as a valuable method in determining cardiovascular (CV) risk and target organ damage. Although hypertension and proteinuria that define preeclampsia/eclampsia may resolve in the majority of women, a significantly greater risk of CV and renal disease is present in their later life.