Antifungal Potentials of Asian Plants: Ethnobotanical Insights and Phytochemical Investigations.

Introduction: Ethnomedicinal plants in Asia offer a promising, low-side-effect alternative to synthetic drugs for treating fungal infections, one of the most widespread communicable diseases caused by pathogenic fungi. Despite being underexplored, the region's rich plant diversity holds the potential for developing effective antifungal drugs. Research is increasingly focused on bioactive compounds from these plants, which show strong antifungal properties and may serve as leads for new drug development.

Indian Shot ( L). Leaves Provide Valuable Insights into the Management of Inflammation and Other Associated Disorders Offering Health Benefits.

Background: Throughout history, plants have played a crucial role in advancing medicinal treatments by providing a diverse range of compounds for the development of innovative therapies. L. a tropical herb of the Cannaceae family, also known as Indian shot, has a rich history of traditional use in treating ailments like inflammation, malaria, dysentery, fever, dropsy, and diarrhea.

Unlocking the medicinal arsenal of : GC-MS/MS, FTIR, and molecular docking insights.

Background And Aims: This study investigated the biochemical components present in the leaves of . The primary aim was to analyze these components using advanced techniques and assess their potential therapeutic applications.

Methodology: Fourier Transform Infrared (FT-IR) spectroscopy, Gas Chromatography-Mass Spectrometry (GC-MS), and Mass Spectral analysis were employed to identify and characterize the compounds in leaves.

Phyto-pharmacological and computational profiling of Linn. Leaves revealed pharmacological properties against oxidation, hyperglycemia, pain, and diarrhea.

The present study aimed to conduct phytochemical and pharmacological profiling of methanolic crude extract of leaves of Linn. via experimental and computational approaches. Six secondary metabolites were isolated chromatographically, and the structures were elucidated by extensive analyses of high-resolution H and C NMR data.

Isolation, characterization and pharmacological potentials of methanol extract of leaves: Evidenced from mice model along with molecular docking analysis.

The purpose of the current investigation was to conduct a detailed analysis of the chemical components and medicinal properties of the methanolic crude extract derived from the leaves of Cassia fistula. This analysis was carried out using both experimental (in vivo) and computational (in silico) methods. Eleven chemicals were chromatographically isolated using GC-MS/MS, which utilizes a library of NIST and Wiley 2020 versions.

Preparation of fluorescent sensor based on Zn metal-organic framework for detection and determination of raloxifene as an anticancer drug.

Breast cancer is the second leading cause of death for women worldwide. Raloxifene (RLX) is a somewhat effective drug in lowering cholesterol, preventing and treating invasive breast cancer in postmenopausal women with osteoporosis, and does not interfere with breast tissue. Nevertheless, considering the possibility of risk in biological function due to excessive use of anticancer drugs and the adverse effects of drugs in wastewater on plants, animals, and aquatic, it is useful to determine the concentration of RLX in water and human body fluids.

Developing an exclusive sensor based on molecularly imprinted polymer/Multi-walled carbon nanotubes/FeO@Au nanocomposite for the selective determination of an anti-cancer drug imatinib.

Determination of pharmaceuticals especially anticancer drugs is one of the important issues in environmental and medical investigation and creating good information about human health. The presence sturdy introducing an electroanalytical sensor based on molecularly imprinted polymer (MIP)/Multi-walled carbon nanotubes (MWCNTs)/Au@FeO nanoparticles modified carbon paste electrode (PE) to determine imatinib (IMA). The MIP/MWCNTs/Au@FeO/PE showed catalytic activity and also a sensitive strategy to sensing IMA in the concentration range 1-1000 μM with a limit of detection of 0.

Cu-BTC MOF/ionic liquid nanocomposite as novel catalyst to electrochemical monitoring of digoxin in pharmaceutical and environmental samples.

There is no effective environmental treatment strategy that does not include monitoring for pharmaceutical compounds in environmental and biological fluids. The widespread presence of pharmaceutical-based pollutants in water sources is a significant public health concern. The treatment process relies heavily on maintaining a stable digoxin concentration in bodily fluids.

Simple turn-off fluorescence sensor for determination of raloxifene using gold nanoparticles stabilized by chitosan hydrogel.

It is essential to develop a simple, applicable, and reliable assay to anticancer drug raloxifene (RAF) because of its significant usage and side effect due to entering residue in the environment. Fluorescence sensors developed and widely used because of them high selectivity, fast-response, and highly-sensitivity. The gold nanoparticles using chitosan hydrogel was synthesized and applied as a fluorescence sensor to determine the trace amount of RAF.

Facile Synthesis of NiO/ZnO nanocomposite as an effective platform for electrochemical determination of carbamazepine.

The pharmaceutical science demand for sustainable and selective electrochemical sensors which exhibit ultrasensitive capabilities for the monitoring of different drugs. In an attempt to build a useful electrochemical sensor, we describe a most efficient method for the fabrication of NiO/ZnO nanocomposite through aqueous chemical growth method. The successfully synthesized NiO/ZnO nanocomposite is successfully employed to modify a glassy carbon electrode in order to build a sensitive and reliable electrochemical sensor for the detection of carbamazepine (CBZ), an anticonvulsant drug.

Survey of antibacterial activity and release kinetics of gold-decorated magnetic nanoparticles of Fe0 conjugated with sulfamethoxazole against Escherichia coli and Staphylococcus aureus.

Drug delivery of antibiotics with magnetic nanoparticles improved by coating metals such as gold and silver has recently been studied. This work describe a simple method to synthesize modified magnetic nanoparticles which have high ability to modify the customary formulation of antibiotics such as sulfamethoxazole (SMX) and pursuant study of adsorption-desorption (release) of this drug. These synthesized nanoparticles were characterized by different methods, including field emission scanning electron microscopy, energy dispersive X-ray spectroscopy and mapping, Fourier-transform infrared spectroscopy, X-ray diffraction, vibrating-sample magnetometry, thermogravimetric analysis and zeta potential test.

Advancement in electrochemical strategies for quantification of Brown HT and Carmoisine (Acid Red 14) From Azo Dyestuff class.

Brown HT and carmoisine, which are the most used dyestuffs in pharmaceuticals, textiles, cosmetics and foods, are important components of the Azo family. Although the Azo group is not toxic or carcinogenic under normal conditions, these dyestuffs require great care due to the reduction of the Azo functional group to amines. In particular, fast, reliable, easy, on-site and precise determinations of these substances are extremely necessary and important.

Magnetic nanoparticles based on cerium MOF supported on the MWCNT as a fluorescence quenching sensor for determination of 6-mercaptopurine.

In this study, a new magnetic nanocomposite was developed as an efficient and fast-response fluorescence quenching sensor for determination of anticancer drug 6-mercaptopurine (6-MP). For this purpose, the needle-shape fluorescence metal-organic framework of cerium (Ce-MOF) were successfully synthesized on the surface of multiwalled carbon nanotubes using 1,3,5-benzenetricarboxylic acid ligand via a facile solvothermal assisted route and magnetized. The accuracy of the proposed synthesis was confirmed using the FT-IR, FE-SEM, XRD, and VSM methods.

Ultrasensitive and highly selective "turn-on" fluorescent sensor for the detection and measurement of melatonin in juice samples.

Melatonin (MLT), a hormone related to the regulation of brain functions, is directly related to sleep quality and is considered to be a possible adjuvant therapy for patients needing hospitalization for coronavirus disease 2019 pneumonia, and accurate measurement of MLT is crucial. Herein, a new, highly sensitive, and easy operation fluorescent probe was provided based on Zr metal-organic framework encapsulation into the molecularly imprinted polymer (MOF@MIP). By combining unique properties of MIP and fluorescent MOF, selectivity and operation of the applied method were significantly improved.

The evolution of a coordinator from a vocative source: the case of the disjunctive in Jordanian Arabic.

This research paper proposes that a vocative can be a potential source of coordination, thus it adds to the literature on the grammaticalization of coordinators. Evidence to this proposal is taken from Jordanian Arabic (JA) wherein the vocative particle : developed a disjunctive (coordination) function. The synchronic evidence to the evolution of the disjunctive is that this function is conveyed by this particle in some but not all Arabic varieties, whereas the vocative function is the common cross-dialectal function of .

New fabrication of CuFe2O4/PAMAM nanocomposites by an efficient removal performance for organic dyes: Kinetic study.

Today, removing pollutants from water sources is essential because of the population increase and the growing need for safe drinking water. Dyes are one of the most critical pollutants from industrial effluents such as paper and textile industries that profoundly affect the environment. There are several ways to remove environmental contaminants.

Novel enzymatic graphene oxide based biosensor for the detection of glutathione in biological body fluids.

In this work, we report a novel enzymatic biosensor based on glutathione peroxidase (GSH-Px), graphene oxide (GO) and nafion for the electrochemical sensing of glutathione (GSH) in body fluids. GSH-Px was immobilized covalently via 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) onto modified glassy carbon electrode (GCE) decorated with GO and nafion and successfully used for sensing of GSH in the presence of HO as catalyst with Michaelis-Menten constant about 0.131 mmol/L.

Doxorubicin Anticancer Drug Monitoring by ds-DNA-Based Electrochemical Biosensor in Clinical Samples.

In this research, glassy carbon electrode (GCE) amplified with single-wall carbon nanotubes (SWCNTs) and ds-DNA was fabricated and utilized for voltammetric sensing of doxorubicin with a low detection limit. In this technique, the reduction in guanine signal of ds-DNA in the presence of doxorubicin (DOX) was chosen as an analytical factor. The molecular docking study revealed that the doxorubicin drug interacted with DNA through intercalation mode, which was in agreement with obtained experimental results.

A sensitive and fast approach for voltammetric analysis of bisphenol a as a toxic compound in food products using a Pt-SWCNTs/ionic liquid modified sensor.

A sensitive and fast approach has been introduced for the voltammetric sensing of bisphenol A based on modification of a paste electrode with Pt-SWCNTs and 1-ethyl-3-methylimidazolium n-butylsulfate as a highly conductive binder. The new sensor was used to determine the concentration of bisphenol A in food products in I-V mode. The Pt-SWCNTs nanocomposite was synthesized through the polyol method and its morphology was evaluated by field emission scanning electron microscopy, transmission electron microscopy and energy-dispersive X-ray spectroscopy techniques.

A hierarchical 3D camellia-like molybdenum tungsten disulfide architectures for the determination of morphine and tramadol.

A practical technique was applied to fabricate MoWS nanocomposite through a one-pot hydrothermal method for use as the electrocatalyst. The characterization of MoWS nanocomposite was investigated by several techniques to identify the size, crystal structure, and elemental composition. MoWS nanocomposite exhibited a unique and well-defined hierarchical structure with neatly and densely piled nanopetals acting as the active sites in the electrocatalytic reactions.

Fluorescence detection of laccases activity by the photoinduced electron transfer (PET) process.

Laccases play a vital role in some physiological processes, for example in morphogenesis, carbon cycle, and defense against parasitism. So, designing a high-sensitivity accurate method is essential for researchers. In this study, a simple fluorescence method based on the function of carbon nitride (g-CN) by dopamine is synthesized.

Facile synthesis and characterization of magnetic nanocomposite ZnO/CoFeO hetero-structure for rapid photocatalytic degradation of imidacloprid.

This work has attempted to investigate the potential of ZnO/CoFeO magnetic nanocomposite to mineralize imidacloprid completely to have sustainable pollutant free and safe water supply. The co-precipitation method was performed to prepare the composites; was performed to characterize composites, scanning electron microscope (SEM), transmission electron microscopy (TEM), energy dispersive x-ray crystallography (EDX), x-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, and vibrating sample magnetometer (VSM). It was attempted to explore and enhance parameters influencing the process and the percentage of imidacloprid degradation, including photocatalyst amount, pesticide concentration, pH, radiation time, and temperature.

Simultaneous voltammetric determination of glutathione, doxorubicin and tyrosine based on the electrocatalytic effect of a nickel(II) complex and of Pt:Co nanoparticles as a conductive mediator.

Glutathione (GSH) is an important tripeptide that plays an important role in preventing damage to reactive oxygen species. An electrochemical assay was fabricated for this purpose by modification of a carbon paste electrode (CPE) with bis(1,10-phenanthroline)(1,10-phenanthroline-5,6-dione)nickel(II) hexafluorophosphate (BPPDNi) as new electro-catalyst and Pt:Co nanoparticle (Pt:CO-NPs) as highly conductive mediator. The analyses were performed at a scan rate of 10 mV/s and at a pH value of 7.