Publications by authors named "Mohammad A Mustafa"
Article Synopsis
- Comprehensive reporting of clinical trial activity is essential, guided by the SPIRIT 2013 and CONSORT 2010 statements, which outline what should be included in protocols and result articles.
- A review analyzed the reporting quality of 9 trial protocols and 76 trial result articles related to pediatric brain tumors, revealing an average adherence of 76.8% for protocols and around 67-71% for result articles to established reporting standards.
- The findings suggest a need for improved reporting quality in pediatric neuro-oncology, especially regarding randomization and blinding, echoing similar issues previously identified in adult trials.
Article Synopsis
- This study is a systematic review focusing on patient-reported outcomes (PROs) in patients with Primary Spinal Intradural Tumours (PSITs), which are rare but can greatly affect quality of life.
- It analyzed 11 studies involving 737 patients, mainly assessing results from surgeries, highlighting that patients reported lower quality of life than healthy individuals, with some improvements noted after surgery for extramedullary tumors.
- The review identified inconsistencies in measuring PROs due to diverse tools used across studies, suggesting a need for standardized measurements and registries for better evaluation of these outcomes in PSIT patients.
Article Synopsis
- * A study analyzing 39 adult patients with TPGs from 1993 to 2021 found that about 20% experienced tumor progression over a median follow-up of 10 years, with a high overall survival rate of 86.5%.
- * The study highlights the importance of identifying risk factors for TPG progression and suggests that future research should focus on larger cohorts for more definitive conclusions about long-term outcomes.
Article Synopsis
- * Recent research is focusing on the molecular biology of meningiomas, using various profiling techniques to improve how these tumors are understood and predicted in terms of prognosis.
- * While detailed molecular analysis of tumors is not yet routine in clinical practice, its increasing availability may lead to better treatment options and overall patient care in the future.
Article Synopsis
- - The review evaluated the quality of reporting in adult neuro-oncology clinical trial protocols and result articles, using the SPIRIT 2013 and CONSORT 2010 guidelines as benchmarks.
- - Researchers identified 7 trial protocols and 36 result articles, finding that trial protocols adhered to SPIRIT guidelines by an average of 79.4%, while trial abstracts and articles followed CONSORT guidelines at 75.3% and 74.5%, respectively.
- - The study concluded that there is a need for better reporting practices in neuro-oncology trials, suggesting that improved awareness among researchers and journal requirements could enhance the transparency and communication of trial results.
Introduction: Brain metastases (BMs) in patients with advanced and metastatic NSCLC are linked to poor prognosis. Identifying genomic alterations associated with BM development could influence screening and determine targeted treatment. We aimed to establish prevalence and incidence in these groups, stratified by genomic alterations.
View Article and Find Full Text PDFArticle Synopsis
- * A systematic review was conducted to analyze patient-reported outcomes and health-related quality of life (HRQoL) after cranioplasty, with 25 studies included in the review.
- * Results showed improvements in physical and social functioning, cosmetic outcomes, and overall HRQoL, highlighting the need for more longitudinal studies using validated tools to better assess these effects.
Article Synopsis
- A systematic review was conducted to identify definitions of cauda equina syndrome (CES) and analyze the time to surgery for patients diagnosed with CES from literature dating back to 1990.
- Out of 110 studies involving over 52,000 patients, only 14.5% adhered to established definitions for CES, with urinary dysfunction being the most reported symptom.
- The findings highlight a growing trend in definition consistency over the past five years but stress the need for a standardized definition and guidelines for reporting and analyzing surgery timing to improve clarity in future research.
Article Synopsis
- Intracranial meningiomas involving bones and primary intraosseous meningiomas are rare, with no clear guidelines for treatment; this study reviews strategies and outcomes over a decade.
- A retrospective analysis of 33 adult patients reveals that most had secondary bone involvement, with many undergoing cranioplasty using various materials like polymethyl methacrylate and titanium mesh, showing a high success rate.
- The findings suggest that while different cranioplasty materials were effective, those that are pre-fabricated may lead to fewer complications, indicating the need for further research in this area.
Article Synopsis
- Tranexamic Acid (TXA) is used to reduce bleeding during meningioma surgery, with a systematic review showing it significantly decreases intraoperative blood loss by about 316 mls.
- The analysis included four studies with 281 patients, but found no significant impact of TXA on transfusion needs, operation time, postoperative seizures, hospital stay duration, or long-term disability outcomes.
- Limitations of the review include a small sample size, insufficient data on secondary outcomes, and lack of a standardized blood loss measurement method, suggesting the need for larger trials to assess the full impact of TXA.
Article Synopsis
- Cerebral cavernous malformations (CCMs) have a low long-term hemorrhage rate, with this study aiming to identify risk factors for future hemorrhages in patients.
- Conducted from 2007 to 2019, the study analyzed 545 patients and found that 52.5% presented with symptoms, and the annual hemorrhage rate was 1% per lesion-year, particularly higher for symptomatic patients.
- Key predictive factors for symptomatic hemorrhage included cavernoma size, location in eloquent brain areas, and previous symptomatic hemorrhage, which could aid in patient management strategies.
Article Synopsis
- After meningioma surgery, about one-third of patients have leftover tumors that need regular monitoring, but their growth rates are not well understood.
- The study focused on measuring the volumetric growth rates of these residual tumors in patients treated at a neurosurgery center from 2004 to 2020, using MRI scans and specific growth models.
- Results showed that most tumors grew slowly over time, with factors like tumor location and Ki-67 index helping to predict the likelihood of progression, which is important for determining treatment strategies.
Article Synopsis
- The study investigates long-term health-related quality of life (HRQoL) in meningioma patients, particularly those with tumors that are monitored but not surgically treated.
- Using patient-reported outcome measures, significant HRQoL impairments were found in various areas, especially for those with lower education levels, unemployment, or who faced postoperative complications.
- The findings emphasize the ongoing burden meningioma has on patients nearly a decade post-diagnosis, suggesting healthcare providers should pay attention to HRQoL and offer support resources accordingly.
Article Synopsis
- Sporadic multiple meningiomas are rare and associated with lower overall survival compared to solitary meningiomas, but this study explores their clinical outcomes.
- A matched cohort study analyzed 34 patients with multiple meningiomas and found similar intervention rates, recurrence-free survival, and overall survival when compared to those with solitary meningiomas.
- The findings suggest that sporadic multiple meningiomas may not lead to worse outcomes, indicating that treatment should focus on symptomatic or high-risk asymptomatic cases.
Article Synopsis
- Systematic reviews (SR) and systematic reviews with meta-analysis (SRMA) are vital for guiding clinical practice related to meningioma, yet their overall quality and reporting standards were found to be lacking.
- A search of eight databases identified 116 eligible SRs published between 1990 and 2020, with most studies scoring low on various quality assessment tools like PRISMA and AMSTAR 2.
- The findings suggest that improvements in methodological practices and adherence to established guidelines are necessary to enhance the validity and transparency of research in this area.
Article Synopsis
- Glioblastoma is a serious brain tumor with a low survival rate (12-15 months) even with aggressive treatment, highlighting the need for effective follow-up imaging practices post-surgery.
- This study aims to analyze current MRI monitoring routines after glioblastoma surgery in the UK and Ireland and see how following NICE guidelines impacts patient outcomes.
- A total of 450 patients will be included in this retrospective study, with data on treatment and follow-up collected to evaluate survival outcomes, while ethical approval for data collection is managed at each institution.
Article Synopsis
- Long-standing overt ventriculomegaly in adults (LOVA) involves various conditions with different symptoms, and there's limited research on the effectiveness of surgical treatments like endoscopic third ventriculostomy (ETV) and ventriculoperitoneal shunt (VPS).
- In a study involving 127 adults with LOVA, most patients experienced symptoms such as gait issues, headaches, and cognitive decline, with many undergoing surgical treatment.
- Results showed that 82.4% of those who had surgery experienced clinical improvement, with ETV leading to fewer complications compared to VPS, indicating that ETV is an effective first-line treatment option for LOVA.
Article Synopsis
- This study analyzed outcomes of first alloplastic cranioplasty in 287 patients, focusing on post-surgery complications and factors influencing the need for explantation, which is the removal of the implanted material.* -
- Most patients were around 43 years old, with traumatic brain injury being the leading reason for prior craniectomy; various materials, such as titanium and hydroxyapatite, were used for the cranioplasty.* -
- Results showed a 12.2% rate of all-cause explantation, with certain materials like hydroxyapatite and acrylic significantly lowering the risk of complications, while age and certain conditions increased the risk.*
Purpose: To externally validate the arteriovenous malformation-related intracerebral haemorrhage (AVICH), intracerebral haemorrhage (ICH), and novel haemorrhage presentation risk score (R2eD) in brain arteriovenous malformations.
Methods: Adult patients diagnosed radiologically with an arteriovenous malformation (AVM) at a tertiary neurosurgical centre between 2007 and 2018 were eligible for inclusion. Both the AVICH and ICH scores were calculated for AVM-related symptomatic haemorrhage (SH) and compared against the modified Rankin scale (mRS) at discharge and last follow-up, with unfavourable outcome defined as mRS > 2.
Introduction The temporomandibular joint (TMJ) is an important joint that plays major functions, including dental occlusion, mastication, and facial expressions. Different diseases can affect the TMJ, including chronic inflammatory arthritis. Rheumatoid arthritis (RA) is the most common inflammatory arthritis worldwide associated with TMJ dysfunction.
View Article and Find Full Text PDFThe outcomes following re-operation for meningioma are poorly described. The aim of this study was to identify risk factors for a performance status outcome following a second operation for a recurrent meningioma. A retrospective, comparative cohort study was conducted.
View Article and Find Full Text PDFThe impact of Covid-19 on surgical patients worldwide has been substantial. In the United Kingdom (UK) and the Republic of Ireland (RoI), the first wave of the pandemic occurred in March 2020. The aims of this study were to: (1) evaluate the volume of neurosurgical operative activity levels, Covid-19 infection rate and mortality rate in April 2020 with a retrospective cross-sectional cohort study conducted across 16 UK and RoI neurosurgical centres, and (2) compare patient outcomes in a single institution in April-June 2020 with a comparative cohort in 2019.
View Article and Find Full Text PDFSurgical resection of meningioma leaves residual solid tumour in over 25% of patients. Selection for further treatment and follow-up strategy may benefit from knowledge of volumetric growth and factors associated with re-growth. The aim of this review was to evaluate volumetric growth and variables associated with growth in patients that underwent incomplete resection of a meningioma without the use of adjuvant radiotherapy.
View Article and Find Full Text PDF