Publications by authors named "Mohammad A Mahmoud"
Avascular necrosis (AVN) is a debilitating condition characterized by bone tissue death due to inadequate blood supply, leading to joint dysfunction and collapse. This study investigates the potential association between AVN and COVID-19, focusing on genetic factors such as NOS3 polymorphisms. A total of 180 individuals were included, comprising 120 COVID-19 patients and 60 healthy controls.
View Article and Find Full Text PDFTo evaluate the phytochemical composition, antibacterial, and antioxidant activity of successive extracts of L. () aerial flowering parts, they were assessed in vitro. Using a spectrophotometer, the sample absorbance at 517 nm was used to quantify the scavenging activity.
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- Traditional herbal medicine, particularly Thymoquinone (TQ) from black seed and Piperine (PIP) from black pepper, shows promise in enhancing the effects of the cancer drug sorafenib (SOR) against triple-negative breast and liver cancer cells.
- The study utilized various methods like MTT assays and flow cytometry to analyze the cytotoxicity and the mechanisms of action, including effects on DNA methylation and histone acetylation.
- Results indicated that TQ and PIP combined with SOR led to increased cancer cell death and growth inhibition by downregulating certain oncogenic proteins and upregulating tumor suppressor miRNA-29c, while molecular docking studies confirmed strong interactions among these compounds.
In Vivo Interrelationship between Insulin Resistance and Interferon Gamma Production: Protective and Therapeutic Effect of Berberine.
Evid Based Complement Alternat Med
September 2016
This research was conducted to investigate if there is a relation between insulin resistance incidence and inhibition of interferon gamma production or not. Firstly, insulin resistance was induced by high fat diet (HFD) intake for 6 weeks. Secondly, berberine was used as protective/curative compound for insulin resistance.
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